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Shipilova N.N.

Federal Center for Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Katunina E.A.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Titova N.V.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Malykhina E.A.

Federal Center for Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Katunin D.A.

Federal Center of Brain and Neurotechnologies

Pogorova A.R.

Federal Center for Brain Research and Neurotechnologies

Dzhafarov V.M.

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Gumin I.S.

Federal Center of Brain Research and Neurotechnologies

Senko I.V.

Federal Center of Brain Research and Neurotechnologies

Dolgushin M.B.

Federal Center of Brain and Neurotechnologies of the Federal Medical Biological Agency

Repeated unilateral FUS thalamotomy in patients with tremor-dominant forms of Parkinson’s disease

Authors:

Shipilova N.N., Katunina E.A., Titova N.V., Malykhina E.A., Katunin D.A., Pogorova A.R., Dzhafarov V.M., Gumin I.S., Senko I.V., Dolgushin M.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11): 77‑85

DOI: 10.17116/jnevro202512511177

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Table of contents

REPEATED UNILATERAL FUS THALAMOTOMY IN PATIENTS WITH TREMOR-DOMINANT FORMS OF PARKINSON’S DISEASE
REPEATED UNILATERAL FUS THALAMOTOMY IN PATIENTS WITH TREMOR-DOMINANT FORMS OF PARKINSON’S DISEASE

To cite this article:

Shipilova NN, Katunina EA, Titova NV, et al. Repeated unilateral FUS thalamotomy in patients with tremor-dominant forms of Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11):77‑85. (In Russ.)
https://doi.org/10.17116/jnevro202512511177

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive therapy for tremor based on focusing ultrasound in the deep parts of the brain without damaging adjacent tissues. Despite many benefits, the procedure has its side effects. In addition, some patients show a relapse of tremor some time after the procedure. The question of the need for repeated surgery on the same side remains debatable. The article presents two clinical cases of repeated unilateral FUS thalamotomy in patients with Parkinson’s disease (PD) due to the relapse of tremor after the first procedure. Factors that may contribute to the effectiveness of the intervention or increase the risk of adverse events are described. Further studies are needed to establish the indications and contraindications for repeated FUS thalamotomy on the same side in patients with PD.

Keywords:

Parkinson’s disease
tremor-dominant form
resistant tremor
magnetic resonance-guided focused ultrasound
MRgFUS

Authors:

Shipilova N.N.

Federal Center for Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Katunina E.A.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Titova N.V.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Malykhina E.A.

Federal Center for Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Katunin D.A.

Federal Center of Brain and Neurotechnologies

Pogorova A.R.

Federal Center for Brain Research and Neurotechnologies

Dzhafarov V.M.

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Gumin I.S.

Federal Center of Brain Research and Neurotechnologies

Senko I.V.

Federal Center of Brain Research and Neurotechnologies

Dolgushin M.B.

Federal Center of Brain and Neurotechnologies of the Federal Medical Biological Agency

Received:

11.08.2025

Accepted:

15.08.2025

Close metadata

References:

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  2. Focus Ultrasound Foundation (fusfoundation.org) [Electronic resource]. Accessed July 20, 2025. https://www.fusfoundation.org
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  5. Yamamoto K, Ito H, Fukutake S, et al. Focused ultrasound thalamotomy for tremor-dominant Parkinson’s disease: a prospective 1-year follow-up study. Neurol Med Chir. 2021;61:414-421.  https://doi.org/10.2176/nmc.oa.2020-0370
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  9. Monteiro JDS., Silva BB, de Oliveira RR, et al. Magnetic resonance-guided focused ultrasound ventral intermediate thalamotomy for Tremor-Dominant Parkinson’s disease: a systematic review and meta-analysis. Neurosurgical review. 2024;47(1):701.  https://doi.org/10.1007/s10143-024-02948-2
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  11. Zaaroor M, Sinai A, Goldsher D, et al. Magnetic resonance-guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson’s disease and essential tremor cases. Journal of neurosurgery. 2018;128(1):202-210.  https://doi.org/10.3171/2016.10.JNS16758
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