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Cherdak M.A.

Pirogov Russian National Research Medical University

Mkhitaryan E.A.

Pirogov Russian National Research Medical University;
Russian Clinical and Research Center of Gerontology Pirogov — Russian National Research Medical University

Post-COVID syndrome in the neurological practice

Authors:

Cherdak M.A., Mkhitaryan E.A.

More about the authors

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To cite this article:

Cherdak MA, Mkhitaryan EA. Post-COVID syndrome in the neurological practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2023123071124

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References:

  1. Mokhtari T, Hassani F, Ghaffari N, et al. COVID-19 and multiorgan failure: A narrative review on potential mechanisms. J Mol Histol. 2020 Dec;51(6):613-628.  https://doi.org/10.1007/s10735-020-09915-3
  2. Asfandiyarova NS. Post-COVID-19 syndrome. Clinical Medicine (Russian Journal). 2021;99(7-8):429-435. (In Russ.). https://doi.org/10.30629/0023-2149-2021-99-7-8-429-435
  3. Venkatesan P. NICE guideline on long COVID. Lancet Respir Med. 2021;9(2):129.  https://doi.org/10.1016/S2213-2600(21)00031-X
  4. Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601-615.  https://doi.org/10.1038/s41591-021-01283-z
  5. Post-COVID Conditions: Information for Healthcare Providers. Accessed: 20.03.2023. Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions.html
  6. Post COVID-19 condition. Accessed: 20.03.2023. Available at: https://www.who.int/teams/health-care-readiness/post-covid-19-condition
  7. Chen C, Haupert SR, Zimmermann L, et al. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. J Infect Dis. 2022;226(9):1593-1607. https://doi.org/10.1093/infdis/jiac136
  8. Pazukhina E, Andreeva M, Spiridonova E, et al. Sechenov StopCOVID Research Team. Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID). BMC Med. 2022;20(1):244.  https://doi.org/10.1186/s12916-022-02448-4
  9. Prevalence of post COVID-19 condition symptoms: a systematic review and meta-analysis of cohort study data, stratified by recruitment setting. Technical report of European Centre for Diease Prevention and Control. Accessed: 20.03.2023. Available at: https://www.ecdc.europa.eu/sites/default/files/documents/Prevalence-post-COVID-19-condition-symptoms.pdf
  10. Montenegro P, Moral I, Puy A, et al. Prevalence of Post COVID-19 Condition in Primary Care: A Cross Sectional Study. Int J Environ Res Public Health. 2022;19(3):1836. https://doi.org/10.3390/ijerph19031836
  11. Putilina MV, Mutovina ZYu, Kurushina OV, et al. Determination of the prevalence of postcovid syndrome and assessment of the effectiveness of the drug Cortexin in the treatment of neurological disorders in patients with postcovid syndrome. Results of the multicenter clinical and epidemiological observational program CORTEX. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2022;122(1):84-90. (In Russ.). https://doi.org/10.17116/jnevro202212201184
  12. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep. 2021;11(1):16144. https://doi.org/10.1038/s41598-021-95565-8
  13. Petrova LV, Kostenko EV, Eneeva MA. Asthenia and Post-COVID Syndrome: Pathogenesis, Clinical Presentations, Diagnosis, and Medical Rehabilitation. Doctor Ru. 2021;20(9):36-42. (In Russ.). https://doi.org/10.31550/1727-2378-2021-20-9-36-42
  14. Davis HE, Assaf GS, McCorkell L, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021 Aug; 38:101019. https://doi.org/10.1016/j.eclinm.2021.101019
  15. Ceban F, Ling S, Lui LMW, et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun. 2021;101:93-135.  https://doi.org/10.1016/J.BBI.2021.12.020
  16. Morgul E, Bener A, Atak M, et al. COVID-19 pandemic and psychological fatigue in Turkey. Int J Soc Psychiatry. 2021 Mar;67(2):128-135.  https://doi.org/10.1177/0020764020941889
  17. Salari N, Khodayari Y, Hosseinian-Far A, et al. Global prevalence of chronic fatigue syndrome among long COVID-19 patients: A systematic review and meta-analysis. Biopsychosoc Med. 2022;16(1):21.  https://doi.org/10.1186/s13030-022-00250-5
  18. Gaber T. Assessment and management of post-COVID fatigue. Prog Neurol Psychiatry. 2021;25:36-39.  https://doi.org/10.1002/pnp.698
  19. Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome a case-controlled study. BMC Neurol. 2011;11:37-41.  https://doi.org/10.1186/1471-2377-11-37
  20. Hellmuth J, Barnett TA, Asken BM, et al. Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients. J Neurovirol. 2021;27:191.  https://doi.org/10.1007/S13365-021-00954-4
  21. Salamanna F, Veronesi F, Martini L, et al. Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data. Front Med (Lausanne). 2021 May 4;8:653516. https://doi.org/10.3389/fmed.2021.653516
  22. Afroze F, Arafat SM, Ahmed CM, et al. Features and risk factors of post-COVID-19 syndrome: findings from a longitudinal study in Bangladesh. Lancet Reg Health Southeast Asia. 2022 Dec 23:100134. https://doi.org/10.1016/j.lansea.2022.100134
  23. Batiha GE, Al-Kuraishy HM, Al-Gareeb AI, Welson NN. Pathophysiology of Post-COVID syndromes: a new perspective. Virol J. 2022;19(1):158.  https://doi.org/10.1186/s12985-022-01891-2
  24. Majolo F, Silva GL, Vieira L, et al. Neuropsychiatric disorders and COVID-19: what we know so far. Pharmaceuticals. 2021;14(9):933.  https://doi.org/10.3390/ph14090933
  25. Kumar D, Jahan S, Khan A, et al. Neurological manifestation of SARS-CoV-2 induced inflammation and possible therapeutic strategies against COVID-19. Mol Neurobiol. 2021;58(7):3417-3434. https://doi.org/10.1007/s12035-021-02318-9
  26. Chen R, Wang K, Yu J, et al. The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains. Front Neurol. 2021 Jan 20;11:573095. https://doi.org/10.3389/fneur.2020.573095
  27. Serebrovska ZO, Chong EY, Serebrovska TV. Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to therapeutic targets. Acta Pharmacol Sin. 2020;41:1539-1546. https://doi.org/10.1038/s41401-020-00554-8
  28. Pavli A, Theodoridou M, Maltezou HC. Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals. Arch Med Res. 2021:S0188-4409(21)00081-3.  https://doi.org/10.1016/j.arcmed.2021.03.010
  29. Petrella C, Nenna R, Petrarca L, et al. Serum NGF and BDNF in Long-COVID-19 Adolescents: A Pilot Study. Diagnostics (Basel). 2022 May 7;12(5):1162. https://doi.org/10.3390/diagnostics12051162
  30. Kwon HS, Koh SH. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020 Nov 26;9(1):42.  https://doi.org/10.1186/s40035-020-00221-2
  31. Versace V, Sebastianelli L, Ferrazzoli D, et al. Intracortical GABAergic dysfunction in patients with fatigue and dysexecutive syndrome after COVID-19. Clin Neurophysiol. 2021;132:1138. https://doi.org/10.1016/J.CLINPH.2021.03.001
  32. Putilina MV. Asthenic disorders as a manifestation of chronic fatigue syndrome. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2021;121(8):119-124. (In Russ.). https://doi.org/10.17116/jnevro2021121081119
  33. Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical guidelines on frailty. Russian Journal of Geriatric Medicine. 2020;(1):11-46. (In Russ.). https://doi.org/10.37586/2686-8636-1-2020-11-46
  34. Khasanova DR, Zhitkova YuV, Vaskaeva GR. Post-covid syndrome: a review of pathophysiology, neuropsychiatric manifestations and treatment perspectives. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2021;13(3):93-98. (In Russ.). https://doi.org/10.14412/2074-2711-2021-3-93-98
  35. Yakovlev AA, Gulyaeva NV. Molecular partners of cortexin in the brain. Neurochemistry. 2017;33:1:91-96. (In Russ.). https://doi.org/10.1134/S1819712416040164
  36. Nesterenko AN, Onufriev MV, Gulyaeva NV. Effect of the drug Cortexin on free radical oxidation and inflammatory processes in rats with normal and accelerated aging. Neurochemistry. 2018;2(35):187-198. (In Russ.). https://doi.org/10.7868/S1027813318020127
  37. Kurkin DV, Bakulin DA, Morkovin EI, et al. Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats. PLoS One. 2021 Jul 14;16(7):e0254493. https://doi.org/10.1371/journal.pone.0254493
  38. Ludewig P, Winneberger J, Magnus T. The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation. J Neuroimmunol. 2019;326:38-44.  https://doi.org/10.1016/j.jneuroim.2018.10.012

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