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Levin O.S.

Russian Medical Academy of Continuous Professional Education

Vashchilin V.V.

Republican Research and Clinical Center of Neurology and Neurosurgery

Pikija S.

Paracelsus Private Medical University

Khasanova D.R.

Interregional Clinical and Diagnostic Center;
Kazan State Medical University

Turuspekova S.T.

Asfendiyarov Kazakh National Medical University

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Shmonin A.A.

Pavlov First Saint Petersburg Medical University

Maltceva M.N.

Pavlov First Saint Petersburg Medical University;
Russian Canis-therapy Support and Development Association

Voznyuk I.A.

Yanishevsky S.N.

Kirov Military Medical Academy;
Almazov National Medical Research Centre

Huseynov D.K.

Mingachevir City Hospital

Karakulova Yu.V.

Wagner Perm State Medical University

Obidov F.Kh.

Regional Hospital of Samarkand Region

Current approaches in the treatment and rehabilitation of patients with neurological diseases after COVID-19. Resolution of the International Experts Forum

Authors:

Levin O.S., Vashchilin V.V., Pikija S., Khasanova D.R., Turuspekova S.T., Bogolepova A.N., Shmonin A.A., Maltceva M.N., Voznyuk I.A., Yanishevsky S.N., Huseynov D.K., Karakulova Yu.V., Obidov F.Kh.

More about the authors

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To cite this article:

Levin OS, Vashchilin VV, Pikija S, et al. . Current approaches in the treatment and rehabilitation of patients with neurological diseases after COVID-19. Resolution of the International Experts Forum. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(2):44‑51. (In Russ.)
https://doi.org/10.17116/jnevro202312302144

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References:

  1. Huang C, Huang L, Wang Y, at al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397:220-232.  https://doi.org/10.1016/S0140-6736(20)32656-8
  2. Zhang C, Chopp M, Cui Y, et al. Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res. 2010;88(15):3275-3281. https://doi.org/10.1002/jnr.22495
  3. Zhang Y, Chopp M, Meng Y, et al. Improvement in functional recovery with administration of Cerebrolysin after experimental closed head injury. J Neurosurg. 2013;118(6):1343-1355. https://doi.org/10.3171/2013.3.JNS122061
  4. Evans MRB, White P, Cowley P, et al. Revolution in acute ischaemic stroke care: A practical guide to mechanical thrombectomy. Pract Neurol. 2017;17:252-265. 
  5. Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: A meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723-1731.
  6. Lees KR, Emberson J, Blackwell L, et al. Effects of alteplase for acute stroke on the distribution of functional outcomes: A pooled analysis of 9 trials. Stroke. 2016;47:2373-2379.
  7. Teo KC, Leung WCY, et al. Delays in stroke onset to hospital arrival time during covid-19. Stroke. 2020;51(7):2228-2231. https://doi.org/10.1161/STROKEAHA.120.030105
  8. Rudilosso S, Laredo C, Vera V, et al. Acute stroke care is at risk in the era of COVID-19: Experience at a comprehensive stroke center in Barcelona. Stroke. 2020;51(7):1991-1995. https://doi.org/10.1161/STROKEAHA.120.030329
  9. Mackintosh JE, Murtagh MJ, Rodgers H, et al. Why people do, or do not, immediately contact emergency medical services following the onset of acute stroke: Qualitative interview study. PLoS One. 2012;7:e46124.
  10. Zhao J, Rudd A, Liu R. Challenges and potential solutions of stroke care during the coronavirus disease 2019 (COVID-19) outbreak. Stroke. 2020;51:1356-1357.
  11. Organization ES. European stroke organization. Stroke care during COVID-19 pandemic. 2020. https://eso-stroke.org/guidelines/eso-guideline-directory-app
  12. Athanasios A, Daley I, Patel A, et al. Cerebrovascular Accident and SARS-CoV-19 (COVID-19): A Systematic Review. Eur Neurol. 2021;84(6):418-425.  https://doi.org/10.1159/000517403
  13. Alhashim A, Alqarni M, Alabdali M, et al. Large Vessel Occlusion Causing Cerebral Ischemic Stroke in Previously Healthy Middle-Aged Recently Recovered from Severe COVID-19 Infection. Int Med Case Rep J. 2021;14:577-582.  https://doi.org/10.2147/IMCRJ.S327196
  14. Katsoularis I, Fonseca-Rodríguez O, Farrington P, et al. Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study. Lancet. 2021;398(10300):599-607.  https://doi.org/10.1016/S0140-6736(21)00896-5
  15. Stein LK, Mayman NA, Dhamoon MS, Fifi JT. The emerging association between COVID-19 and acute stroke. Trends Neurosci. 2021;44(7):527-537.  https://doi.org/10.1016/j.tins.2021.03.005
  16. Strambo D, De Marchis GM, Bonati LH, et al.; Swiss Stroke Registry Investigators. Ischemic stroke in COVID-19 patients: Mechanisms, treatment, and outcomes in a consecutive Swiss Stroke Registry analysis. Eur J Neurol. 2022;29(3):732-743.  https://doi.org/10.1111/ene.15199
  17. Dhamoon MS, Thaler A, Gururangan K, et al.; Mount Sinai Stroke Investigators. Acute Cerebrovascular Events With COVID-19 Infection. Stroke. 2021;52(1):48-56.  https://doi.org/10.1161/STROKEAHA.120.031668
  18. Vidale S. Risk Factors, and Clinical and Etiological Characteristics of Ischemic Strokes in COVID-19-Infected Patients: A Systematic Review of Literature. Cerebrovasc Dis. 2021;50(4):371-374.  https://doi.org/10.1159/000514267
  19. Perry RJ, Smith CJ, Roffe C, et al.; SETICOS collaborators. Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study. J Neurol Neurosurg Psychiatry. 2021;92(3):242-248.  https://doi.org/10.1136/jnnp-2020-324927
  20. Ramos AD, Koyfman F, Byrns K, et al. Characterization of Hemorrhagic and Ischemic Stroke in a Diverse Cohort of COVID-19 Patients. Neurohospitalist. 2021;11(4):295-302.  https://doi.org/10.1177/1941874421990545
  21. Martí-Fàbregas J, Guisado-Alonso D, Delgado-Mederos R, et al.; COVICTUS Collaborators. Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke. Stroke. 2021;52(12):3908-3917. https://doi.org/10.1161/STROKEAHA.121.034883
  22. Tu TM, Seet CYH, Koh JS, et al. Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men. JAMA Netw Open. 2021;4(4):e217498. https://doi.org/10.1001/jamanetworkopen.2021.7498
  23. Li P, Zhao W, Kaatz S, et al. Associated With Risk of Postdischarge Thrombosis in Patients With COVID-19. JAMA Netw Open. 2021;4(11):e2135397. https://doi.org/10.1001/jamanetworkopen.2021.35397
  24. Papadopoulos A, Palaiopanos K, Björkbacka H, et al. Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies. Neurology. 2022;98(10):e1002-e1012. https://doi.org/10.1212/WNL.0000000000013274
  25. Zakeri A, Jadhav AP, Sullenger BA, Nimjee SM. Ischemic stroke in COVID-19-positive patients: an overview of SARS-CoV-2 and thrombotic mechanisms for the neurointerventionalist. J Neurointerv Surg. 2021;13(3):202-206.  https://doi.org/10.1136/neurintsurg-2020-016794
  26. Chowdhury T, Rizk AA, Daniels AH, et al. Management of Acute Ischemic Stroke in the Interventional Neuroradiology Suite During the COVID-19 Pandemic: A Global Survey. J Neurosurg Anesthesiol. 2021;33(1):44-50.  https://doi.org/10.1097/ANA.0000000000000734
  27. Lavi E, Cong L. Type I astrocytes and microglia induce a cytokine response in an encephalitic murine coronavirus infection. Exp Mol Pathol. 2020;115:104474. https://doi.org/10.1016/j.yexmp.2020.104474
  28. Otsu Y, Namekawa M, Toriyabe M, et al. Strategies to prevent hemorrhagic transformation after reperfusion therapies for acute ischemic stroke: A literature review. J Neurol Sci. 2020;419:117217. https://doi.org/10.1016/j.jns.2020.117217
  29. Mureșanu DF, Livinț Popa L, Chira D, et al. Role and Impact of Cerebrolysin for Ischemic Stroke Care. J Clin Med. 2022;11(5):1273. https://doi.org/10.3390/jcm11051273
  30. Teng H, Li C, Zhang Y, et al. Therapeutic effect of Cerebrolysin on reducing impaired cerebral endothelial cell permeability. Neuroreport. 2021;32(5):359-366.  https://doi.org/10.1097/WNR.0000000000001598
  31. Poljakovic Z, Supe S, Ljevak J, et al. Efficacy and safety of Cerebrolysin after futile recanalisation therapy in patients with severe stroke. Clin Neurol Neurosurg. 2021;207:106767. https://doi.org/10.1016/j.clineuro.2021.106767
  32. Staszewski J, Stȩpień A, Piusińska-Macoch R, et al. Efficacy of Cerebrolysin Treatment as an Add-On Therapy to Mechanical Thrombectomy in Patients With Acute Ischemic Stroke Due to Large Vessel Occlusion: Study Protocol for a Prospective, Open Label, Single-Center Study With 12 Months of Follow-Up. Front Neurol. 2022;13:910697. https://doi.org/10.3389/fneur.2022.910697
  33. Troyer EA, Kohn JN, Hong S. Are We Facing a Crashing Wave of Neuropsychiatric Sequelae of COVID-19? Neuropsychiatric Symptoms and potential Immunologic Mechanisms. Brain Behav Immun. 2020;87:34-39.  https://doi.org/10.1016/j.bbi.2020.04.027
  34. Helms J, Kremer S, Merdji H, et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med. 2020;382(23):2268-2270. https://doi.org/10.1056/NEJMc2008597
  35. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis. medRxiv [Preprint]. 2021 Jan 30:2021.01.27.21250617. https://doi.org/10.1101/2021.01.27.21250617
  36. Mazza MG, Palladini M, Villa G, et al. Prevalence, trajectory over time, and risk factor of post-COVID-19 fatigue. J Psychiatr Res. 2022;155:112-119.  https://doi.org/10.1016/j.jpsychires.2022.08.008
  37. Deng J, Zhou F, Hou W, et al. The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis. Ann NY Acad Sci. 2021;1486(1):90-111.  https://doi.org/10.1111/nyas.14506
  38. Crook H, Raza S, Nowell J, et al. Long covid-mechanisms, risk factors, and management. BMJ. 2021;374:n1648. https://doi.org/10.1136/bmj.n1648
  39. McIntyre RS, Cha DS, Soczynska JK, et al. Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depress Anxiety. 2013;30(6):515-527.  https://doi.org/10.1002/da.22063
  40. Roiser JP, Rubinsztein JS, Sahakian BJ. Neuropsychology of affective disorders. Psychiatry. 2009;8:3:91-96.  https://doi.org/10.1016/j.mppsy.2008.11.007
  41. Moylan S, Maes M, Wray NR, Berk M. The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications. Mol Psychiatry. 2013;18(5):595-606.  https://doi.org/10.1038/mp.2012.33
  42. Latronico N, Peli E, Calza S, et al.; LOTO Investigators. Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS. Thorax. 2022;77(3):300-303.  https://doi.org/10.1136/thoraxjnl-2021-218064
  43. Liyanage-Don NA, Winawer MR, Hamberger MJ, et al. Association of depression and COVID-induced PTSD with cognitive symptoms after COVID-19 illness. Gen Hosp Psychiatry. 2022;76:45-48.  https://doi.org/10.1016/j.genhosppsych.2022.02.006
  44. Brown LA, Ballentine E, Zhu Y, et al. The unique contribution of depression to cognitive impairment in Post-Acute Sequelae of SARS-CoV-2 infection. Brain Behav Immun Health. 2022;22:100460. https://doi.org/10.1016/j.bbih.2022.100460
  45. Chukanova EI. Comparative analysis of Cerebrolysin efficacy in the treatment of patients with chronic cerebral ischemia. Pharmacoeconomic aspects. Trudniy Pacient. 2011;9(1):32-37. (In Russ.).
  46. Chen G, Wu D, Guo W, et al. Clinical and Immunological Features of Severe and Moderate Coronavirus Disease 2019. J Clin Invest. 2020;130(5):2620-2629. https://doi.org/10.1172/JCI137244
  47. Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-Term Cognitive Impairment and Functional Disability among Survivors of Severe Sepsis. JAMA. 2010;304(16):1787-1794. https://doi.org/10.1001/jama.2010.1553
  48. Widmann CN, Heneka MT. Long-Term Cerebral Consequences of Sepsis. Lancet Neurol. 2014;13(6):630-636.  https://doi.org/10.1016/S1474-4422(14)70017-1
  49. Chan KS, Zheng JP, Mok K, et al. SARS: prognosis, outcome and sequelae. Respirology. 2003;8 suppl(suppl 1):36-40.  https://doi.org/10.1046/j.1440-1843.2003.00522.x
  50. Taboada M, Cariñena A, Moreno E, et al. Post-COVID-19 functional status six-months after hospitalization. J Infect. 2021;82(4):31-33.  https://doi.org/10.1016/j.jinf.2020.12.022
  51. Ghosn J, Piroth L, Epaulard O, et al. French COVID cohort study and investigators groups. Persistent COVID-19 symptoms are highly prevalent 6 months after hospitalization: results from a large prospective cohort. Clin Microbiol Infect. 2021;27(7):1041.e1-1041.e4.  https://doi.org/10.1016/j.cmi.2021.03.012
  52. Walle-Hansen MM, Ranhoff AH, Mellingsæter M, et al. Health-related quality of life, functional decline, and long-term mortality in older patients following hospitalisation due to COVID-19. BMC Geriatr. 2021;21(1):199.  https://doi.org/10.1186/s12877-021-02140-x
  53. NIHR Themed Review: Living with Covid19 — Second review; March 2021. https://doi.org/10.3310/themedreview_45225
  54. Office for National Statistics (ONS), released 1 December 2022, ONS website, statistical bulletin. Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 1 July 2021. United Kingdom, Office for National Statistics. 1 July 2021.
  55. Vaes AW, Machado FVC, Meys R, et al. Care Dependency in Non-Hospitalized Patients with COVID-19. J Clin Med. 2020;9(9):2946. https://doi.org/10.3390/jcm9092946
  56. Vaes AW, Goërtz YMJ, Van Herck M, et al. Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members. ERJ Open Res. 2021;7(2):00141-02021. https://doi.org/10.1183/23120541.00141-2021
  57. Nida Z, Gurdasani D, O’Hara ME, et al. Characteristics of long Covid: findings from a social media survey. medRxiv preprint; March 26, 2021. Accessed 10 July 2021. https://doi.org/10.1101/2021.03.21.21253968
  58. Sun T, Guo L, Tian F, et al. Rehabilitation of patients with COVID-19. Expert Rev Respir Med. 2020;14(12):1249-1256. https://doi.org/10.1080/17476348.2020.1811687
  59. Lazzeri M, Lanza A, Bellini R, et al. Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR). Monaldi Arch Chest Dis. 2020;90(1):34-39.  https://doi.org/10.4081/monaldi.2020.1285

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