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Kopachev D.N.

Burdenko Neurosurgical Center

Shishkina L.V.

Burdenko Neurosurgical Center

Shkatova A.M.

Burdenko National Medical Research Center for Neurosurgery

Golovteev A.L.

Epilepsy Center

Troitsky A.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Grinenko O.A.

Mercy Health Saint Mary’s Hospital Grand Rapids

Sharkova S.M.

Research Center of Neurology

Petrosyan D.V.

Research Center of Neurology

Gushcha A.O.

Neurology Research Center;
Russian Medical Academy of Continuing Postgraduate Education

Long-term epilepsy-associated tumors

Authors:

Kopachev D.N., Shishkina L.V., Shkatova A.M., Golovteev A.L., Troitsky A.A., Grinenko O.A., Sharkova S.M., Petrosyan D.V., Gushcha A.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4): 127‑134

DOI: 10.17116/jnevro2022122041127

Read: 8329 times

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Table of contents

LONG-TERM EPILEPSY-ASSOCIATED TUMORS
LONG-TERM EPILEPSY-ASSOCIATED TUMORS

To cite this article:

Kopachev DN, Shishkina LV, Shkatova AM, et al. Long-term epilepsy-associated tumors. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4):127‑134. (In Russ.)
https://doi.org/10.17116/jnevro2022122041127

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

The goal of this review is to summarize data concerning radiological and histological diagnosis of epileptogenic tumors, as well as to discuss their surgical treatment.

MATERIAL AND METHODS

PubMed literature database was searched for relevant articles, we also used our own clinical experience.

RESULTS

Benign glioneuronal tumors are the second most common cause of drug resistant epilepsy in adults after hippocampal sclerosis. Exceptionally slow growth (more than 2 years), localization in the brain cortex, presence of differentiated neuronal tissue in tumoral body and long history of epilepsy are the key features of these tumors called LEAT (long-term epilepsy-associated tumors). Management of LEAT requires epileptological as well as neurooncological approach. The epileptogenic zone commonly spreads beyond the tumor borders and simple lesionectomy alone may not be sufficient for achieving seizure freedom.

CONCLUSION

LEAT typically exhibit low proliferative activity, however they should be thoroughly differentiated from more aggressive glial tumors; while this task is sometimes quite challenging, it’s achievable by means of histological and immunohistochemical examination.

Keywords:

epilepsy
surgery
tumor
ganglioglioma
DNET

Authors:

Kopachev D.N.

Burdenko Neurosurgical Center

Shishkina L.V.

Burdenko Neurosurgical Center

Shkatova A.M.

Burdenko National Medical Research Center for Neurosurgery

Golovteev A.L.

Epilepsy Center

Troitsky A.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Grinenko O.A.

Mercy Health Saint Mary’s Hospital Grand Rapids

Sharkova S.M.

Research Center of Neurology

Petrosyan D.V.

Research Center of Neurology

Gushcha A.O.

Neurology Research Center;
Russian Medical Academy of Continuing Postgraduate Education

Received:

07.09.2021

Accepted:

29.11.2021

Close metadata

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