Correlations between clinical features of bipolar affective disorder and serum concentrations of ANKRD12 gene product, coagulation factor XIII, and cadherin 5

Seregin A.A.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Smirnova L.P.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Dmitrieva E.M.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Boksha I.S.

Mental Health Research Centre;
Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Savushkina O.K.

Mental Health Research Centre

Simutkin G.G.

Mental Health Research Institute — Tomsk National Research Medical Center of Russian Academy Sciences

Ivanova S.A.

Tomsk National Research Medical Center of the Russian Academy of Sciences

ORCID: 0000-0001-7078-323X

Correlations between clinical features of bipolar affective disorder and serum concentrations of ANKRD12 gene product, coagulation factor XIII, and cadherin 5

Authors:

Seregin A.A., Smirnova L.P., Dmitrieva E.M., Boksha I.S., Savushkina O.K., Simutkin G.G., Ivanova S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11): 137‑142

DOI: 10.17116/jnevro2022122111137

Downloaded: 28

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To cite this article:

Seregin AA, Smirnova LP, Dmitrieva EM, Boksha IS, Savushkina OK, Simutkin GG, Ivanova SA. Correlations between clinical features of bipolar affective disorder and serum concentrations of ANKRD12 gene product, coagulation factor XIII, and cadherin 5. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11):137‑142. (In Russ.)
https://doi.org/10.17116/jnevro2022122111137

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To determine the serum concentrations of some proteins identified in the blood serum of patients with bipolar affective disorder (BD) and to evaluate the relationship of their concentrations with clinical characteristics of BD.

MATERIAL AND METHODS

Protein concentrations of cadherin 5, coagulation factor XIII and ANKRD12 gene product in the blood serum of patients with BD and healthy individuals were determined using commercial ELISA kits. The severity of current depression and the main clinical manifestations of BD were assessed by SIGH-SAD and CGI upon admission to the hospital before the prescription of therapy. Data analysis was carried out using the Kruskal—Wallis and Mann—Whitney tests.

RESULTS

Comparison between subgroups of BD patients, selected in accordance with the current affective episode (hypomanic, manic, depressive and mixed), and control group by the Kruskal—Wallis test has shown the significant difference in ANKRD12 protein product concentration (p=0.0448). When comparing pairwise each subgroup with the control group, the significant difference in ANKRD12 product concentration was found only in the case of a subgroup of BD patients with current depressive episode (Mann—Whitney test, p=0.006). Pairwise comparison of the ANKRD12 product concentrations in subgroups of BD patients with different disease duration (<5 years, 6—10 years, and >11 years) and in the control group by the Mann—Whitney test has revealed significant differences (p=0.04, p=0.01, p=0.02, respectively), the maximum protein concentration was found in patients with disease duration >11 years. Significant negative correlation of cadherin 5 concentration with the severity of atypical depressive symptoms assessed by SIGH-SAD (r=–0.69, p=0.038) and the decrease in cadherin 5 concentration in BD patients with greater severity of the current depressive episode were revealed. Significant negative correlation was found between factor XIII concentration and CGI scores (r=–0.62, p=0.032).

CONCLUSION

The results indicate a possible link of the studied proteins with BD pathogenesis. Further study of these proteins may contribute to the development of new therapeutic and diagnostic techniques.

Keywords:

bipolar disorder

cadherin 5

coagulation factor XIII

ANKRD12 gene product

blood serum

Authors:

Seregin A.A.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Smirnova L.P.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Dmitrieva E.M.

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Science

Boksha I.S.

Mental Health Research Centre;
Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Savushkina O.K.

Mental Health Research Centre

Simutkin G.G.

Mental Health Research Institute — Tomsk National Research Medical Center of Russian Academy Sciences

Ivanova S.A.

Tomsk National Research Medical Center of the Russian Academy of Sciences

ORCID: 0000-0001-7078-323X

Received:

01.03.2022

Accepted:

28.09.2022

List of references:

Berk M, Post R, Ratheesh A, et al. Staging in bipolar disorder: from theoretical framework to clinical utility. World Psychiatry. 2017;16(3):236-244. https://doi.org/10.1002/wps.20441
Muchnik PYu, Snedkov EV, Polyakova GYu. The impact of the diagnostic psychiatrists’ opinions on the course of bipolar disorder. Obozrenie psikhiatrii i meditsinskoj psikhologii im. V.M. Bekhtereva. 2014;1:47-56.(In Russ.).
Smirnova L, Seregin A, Boksha I, et al. The difference in serum proteomes in schizophrenia and bipolar disorder. BMC Genomics. 2019;20(Suppl 7):535. https://doi.org/10.1186/s12864-019-5848-1
Popova IG, Chasha TV, Kuzmenko GN, et al. Clinical and laboratory evaluation of endothelial function in the development of perinatal CNS lesions in neonates born to mothers with gestosis. Rossijskij vestnik perinatologii i pediatrii. 2010;55(4):18-22. (In Russ.).
Govorin NV, Vasilyeva AI. Neuromarkers and indices of endothelial dysfunction in acute. Social and Clinical Psychiatry. 2011;1:29-33.(In Russ.).
Hawi Z, Tong J, Dark C, et al. The role of cadherin genes in five major psychiatric disorders: A literature update. Am J Med Genet B Neuropsychiatr Genet. 2018;177(2):168-180. https://doi.org/10.1002/ajmg.b.32592
Shi DY, Wang SJ. Advances of Coagulation Factor XIII. Chin Med J (Engl). 2017;130(2):219-223.
Sugitani K, Koriyama Y, Ogai K, et al. Alternative Splicing for Activation of Coagulation Factor XIII-A in the Fish Retina After Optic Nerve Injury. Adv Exp Med Biol. 2018;1074:387-393. https://doi.org/10.1007/978-3-319-75402-4_48
Zhang A, Yeung PL, Li CW, et al. Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. J Biol Chem. 2004;279(32):33799-33805. https://doi.org/10.1074/jbc.M403997200
Tsankova NM, Berton O, Renthal W, et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9(4):519-525. https://doi.org/10.1038/nn1659
Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry. 1988;45(8):742-747. https://doi.org/10.1001/archpsyc.1988.01800320058007
Busner J, Targum SD. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont). 2007;4(7):28-37.
Gräff J, Joseph NF, Horn ME, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 2014; 156(1-2):261-276. https://doi.org/10.1016/j.cell.2013.12.020
Benes FM, Lim B, Matzilevich D, et al.Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc Natl Acad Sci USA. 2007;104 (24):10164-10169. https://doi.org/10.1073/pnas.0703806104
Morris MJ, Mahgoub M, Na ES, et al. Loss of histone deacetylase 2 improves working memory and accelerates extinction learning. J Neurosci. 2013; 33(15):6401-6411. https://doi.org/10.1523/JNEUROSCI.1001-12.2013
Covington HE 3rd, Maze I, LaPlant QC, et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci. 2009;29(37):11451-11460. https://doi.org/10.1523/JNEUROSCI.1758-09.2009
Lingjaerde O. Blood platelets as a model system for studying serotonergic dysfunction and effects of antidepressants. Pharmacol Toxicol. 1990;66(Suppl 3): 61-68. https://doi.org/10.1111/j.1600-0773.1990.tb02073.x
Nijenhuis AV, van Bergeijk L, Huijgens PC, Zweegman S. Acquired factor XIII deficiency due to an inhibitor: a case report and review of the literature. Haematologica. 2004;89(5):ECR14.

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