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Brusov O.S.

Mental Health Research Center

Karpova N.S.

Mental Health Research Center

Oleĭchik I.V.

Mental Health Research Centre

Faktor M.I.

Mental Health Research Center

Sizov S.V.

Mental Health Research Center

The decrease in procoagulant activity of blood during combined therapy with antidepressants and antipsychotics in patients with endogenous mental disorders

Authors:

Brusov O.S., Karpova N.S., Oleĭchik I.V., Faktor M.I., Sizov S.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11): 55‑60

DOI: 10.17116/jnevro202112111155

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Table of contents

THE DECREASE IN PROCOAGULANT ACTIVITY OF BLOOD DURING COMBINED THERAPY WITH ANTIDEPRESSANTS AND ANTIPSYCHOTICS IN PATIENTS WITH ENDOGENOUS MENTAL DISORDERS
THE DECREASE IN PROCOAGULANT ACTIVITY OF BLOOD DURING COMBINED THERAPY WITH ANTIDEPRESSANTS AND ANTIPSYCHOTICS IN PATIENTS WITH ENDOGENOUS MENTAL DISORDERS

To cite this article:

Brusov OS, Karpova NS, Oleĭchik IV, Faktor MI, Sizov SV. The decrease in procoagulant activity of blood during combined therapy with antidepressants and antipsychotics in patients with endogenous mental disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11):55‑60. (In Russ.)
https://doi.org/10.17116/jnevro202112111155

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To compare the changes in thrombodynamics indices in two groups of patients with endogenous mental disorders before and after combined treatment with antipsychotics and antidepressants (AD + group) and those who did not receive antidepressants (AD-group).

MATERIAL AND METHODS

The study included 110 patients, aged from 16 to 60 years (median age [Q1; Q3] 29 years [22; 35]), admitted for inpatient treatment at the clinic of Mental Health Research Center with the following mental disorders: schizophrenia with attack-like/attack-progressive/continuous type of course (F20.00-2), schizotypal disorder with affective fluctuations (F21.3-4), affective disorder (F 31.1-5; F 32.0-3; F 33.0-3). The thrombodynamics test (TD) was carried out on a T-2 thrombodynamics device according to the manufacturer’s instructions (Hemacore LLC, Moscow, Russia).

RESULTS

In patients with endogenous mental disorders after combined therapy with antidepressants and antipsychotics, a statistically significant decrease in the procoagulant activity of plasma and procoagulant spontaneous clots is observed, which indicates a decrease in the severity of systemic, immune inflammation. In patients with endogenous mental disorders after antipsychotic therapy without the addition of antidepressants, for most thrombodynamic parameters, there is no statistically significant decrease in procoagulant plasma activity and spontaneous clots formation. It indicates the persistence of acute systemic, immune inflammation in this group.

CONCLUSION

The statistically significant positive change in plasma and platelet hemostasis may testify that combined treatment with antipsychotics and antidepressants in patients with endogenous mental disorders may be a biological, pathogenetic link that promotes augmentation (extended action) of antipsychotic therapy.

Keywords:

endogenous mental disorders
antidepressants
antipsychotics
thrombodynamics
hypercoagulation
augmentation

Authors:

Brusov O.S.

Mental Health Research Center

Karpova N.S.

Mental Health Research Center

Oleĭchik I.V.

Mental Health Research Centre

Faktor M.I.

Mental Health Research Center

Sizov S.V.

Mental Health Research Center

Received:

09.04.2021

Accepted:

26.04.2021

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