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Burd S.G.

Pirogov Russian National Research Medical University;
Federal center of brain research and neurotechnologies

Lebedeva A.V.

Pirogov Russian National Research Medical University;
Scientific Research Institute of Healthcare Organization and Medical Managemen

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Rubleva Yu.V.

Federal center of brain research and neurotechnologies

Pizova N.V.

Yaroslavl State Medical University

Vasil’ev S.V.

Expert Legal Centre LLC

Belova A.N.

Privolzhsky Research Medical University

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

Emel’yanova V.V.

Tonus Life Medical Center

Zhadnov V.A.

Ryazan State Medical University named after academician I.P. Pavlov

Ivanova N.E.

Polenov Russian Scientific Research Neurosurgical Institute — branch of Almazov National Medical Research Center

Kalinin V.V.

Moscow Research Institute of Psychiatry Branch of the Serbsky National Medical Research Center for Psychiatry and Narcology

Kissin M.Ya.

First Pavlov State Medical University

Kotov S.V.

Vladimirsky Moscow Regional Research Clinical Institute

Maksimova N.E.

Tver State Medical University

Mikhailov V.A.

Novikov A.E.

Ivanovo State Medical Academy

Poverennova I.Ye.

Seredavin Samara Regional Clinical Hospital

Yamin M.A.

Rostov State Medical University

Clinical results and prospects for the use of phenosanic acid in patients with focal epilepsy

Authors:

Burd S.G., Lebedeva A.V., Pantina N.V., Rubleva Yu.V., Pizova N.V., Vasil’ev S.V., Belova A.N., Vorobeva O.V., Emel’yanova V.V., Zhadnov V.A., Ivanova N.E., Kalinin V.V., Kissin M.Ya., Kotov S.V., Maksimova N.E., Mikhailov V.A., Novikov A.E., Poverennova I.Ye., Yamin M.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10): 52‑59

DOI: 10.17116/jnevro202112110152

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Table of contents

CLINICAL RESULTS AND PROSPECTS FOR THE USE OF PHENOSANIC ACID IN PATIENTS WITH FOCAL EPILEPSY
CLINICAL RESULTS AND PROSPECTS FOR THE USE OF PHENOSANIC ACID IN PATIENTS WITH FOCAL EPILEPSY

To cite this article:

Burd SG, Lebedeva AV, Pantina NV, et al. . Clinical results and prospects for the use of phenosanic acid in patients with focal epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10):52‑59. (In Russ.)
https://doi.org/10.17116/jnevro202112110152

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study the efficacy and safety of using a new original synthetic antioxidant — phenosanic acid as an adjunct therapy in patients with focal epilepsy.

MATERIAL AND METHODS

A randomized, double-blind, placebo-controlled, parallel-group study evaluated the efficacy and safety of phenosanic acid as an adjunct therapy to basic antiepileptic drugs in 120 patients with focal epilepsy. Primary purpose: to study the dynamic of seizure frequency. Secondary purposes: to study the dynamic of seizure-free days, the dynamics of bilateral tonic-clonic seizures, the results of questionnaires and scales (General Dynamics Assessment, Visual Analogue Scale (VAS), Quality of Life in Epilepsy (QOLIE-31-P), European Quality of Life Questionnaire (EQ-5D), Hospital Anxiety and Depression Scale (HADS), Frontal Asstssment Battery (FAB), Mini-Mental State Examination (MMSE)).

RESULTS

Phenosanic acid (Dibufelon) showed statistically significant benefit over placebo in the primary indicator of efficacy (reduction in the frequency of epileptic seizures by at least 50%) and in the secondary indicators. The drug was safe and well tolerated by the patients.

CONCLUSION

The addition of phenosanic acid (Dibufelon) to base antiepileptic drugs seems to be perspective because of its positive effect on reducing the number of epileptic seizures, as well as on comorbid disorders in the emotional and cognitive spheres.

Keywords:

epilepsy
epilepsy treatment
antiepileptic drugs
drug resistance
antioxidants
phenosanic acid
Dibufelon

Authors:

Burd S.G.

Pirogov Russian National Research Medical University;
Federal center of brain research and neurotechnologies

Lebedeva A.V.

Pirogov Russian National Research Medical University;
Scientific Research Institute of Healthcare Organization and Medical Managemen

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Rubleva Yu.V.

Federal center of brain research and neurotechnologies

Pizova N.V.

Yaroslavl State Medical University

Vasil’ev S.V.

Expert Legal Centre LLC

Belova A.N.

Privolzhsky Research Medical University

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

Emel’yanova V.V.

Tonus Life Medical Center

Zhadnov V.A.

Ryazan State Medical University named after academician I.P. Pavlov

Ivanova N.E.

Polenov Russian Scientific Research Neurosurgical Institute — branch of Almazov National Medical Research Center

Kalinin V.V.

Moscow Research Institute of Psychiatry Branch of the Serbsky National Medical Research Center for Psychiatry and Narcology

Kissin M.Ya.

First Pavlov State Medical University

Kotov S.V.

Vladimirsky Moscow Regional Research Clinical Institute

Maksimova N.E.

Tver State Medical University

Mikhailov V.A.

Novikov A.E.

Ivanovo State Medical Academy

Poverennova I.Ye.

Seredavin Samara Regional Clinical Hospital

Yamin M.A.

Rostov State Medical University

Received:

13.09.2021

Accepted:

23.09.2021

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References:

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