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Sorokina E.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Semenova Zh.B.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Averianova N.S.

Federal State Autonomous Institution «National Medical Research Center of Children’s Health» of the Ministry of Health of Russia, Moscow, Russia

Karaseva O.V.

State budgetary healthcare facility «Research Institute of Emergency Pediatric Surgery and Traumatology», Moscow Health Department, Moscow, Russian Federation

Arsenieva E.N.

Research Center of Children Нealth, Moscow

Lukyanov V.I.

Clinical and Research Institute of Emergency Children’s Surgery and Traumatology, Moscow Health Department, Moscow, Russia

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Asanov A.Yu.

Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia

Roshal' L.M.

Nauchno-issledovatel'skiĭ institut neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Pinelis V.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

APOΕ gene polymorphism and markers of brain damage in the outcomes of severe traumatic brain injury in children

Authors:

Sorokina E.G., Semenova Zh.B., Averianova N.S., Karaseva O.V., Arsenieva E.N., Lukyanov V.I., Reutov V.P., Asanov A.Yu., Roshal' L.M., Pinelis V.G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4): 72‑80

DOI: 10.17116/jnevro202012004172

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To cite this article:

Sorokina EG, Semenova ZhB, Averianova NS, et al. . APOΕ gene polymorphism and markers of brain damage in the outcomes of severe traumatic brain injury in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4):72‑80. (In Russ.)
https://doi.org/10.17116/jnevro202012004172

 
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Objective. To compare apolipoprotein E (APOE) genotypes with outcomes and levels of neuromarkers in children with severe traumatic brain injury (TBI). Material and methods. APOE polymorphisms were genotyped in 69 children with severe TBI. The following markers of brain damage were identified: neuron-specific enolase (NSE), glial protein S100b, content of autoantibodies (aAB) to glutamate receptors (to the NR2 subunit of NMDA receptors), aAB to S100b and brain-derived neurotrophic factor (BDNF). Results and Conclusion. There was no association between APOE 3/3, 3/4, 3/2 genotypes and outcomes assessed by the Glasgow Outcome Scale (GOS). The greatest number of favorable outcomes was noted in the group of APOE 3/3 genotype carriers (60%). The ratio of favorable outcomes to unfavorable outcomes was equal (50%:50%) in groups with APOE 3/4 and APOE 3/2 genotypes. An association between APOE polymorphism and BDNF was found: there were normal BDNF levels in the APOE 3/3 group and reduced levels in the APOE 3/2 group. The correlation between neuromarkers and GOS scores was shown for BDNF and aAB to S100b. In children with favorable TBI outcomes, normal BDNF levels and a lower level of aAB to S100b were observed. Regardless of APOE genotypes, almost all children with severe TBI (95%) showed a significant increase in aAB to glutamate receptors in the remote period and most children had an increase in aAB to S100b in the blood. This fact can be explained by the presence of cerebral hypoxia, activation of autoimmune processes and increased BBB permeability, which may be enhanced by increased NO content and intensification of oxidative processes in children with severe TBI.

Keywords:

apolipoprotein E (APOE 4) gene polymorphism
APOE (ε3
ε4
ε2) alleles
traumatic brain injury (TBI)
Glasgow outcome scale (GOS)
neuromarkers (NSE
S100b
BDNF)
autoantibodies to glutamate receptors and to S100b

Authors:

Sorokina E.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Semenova Zh.B.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Averianova N.S.

Federal State Autonomous Institution «National Medical Research Center of Children’s Health» of the Ministry of Health of Russia, Moscow, Russia

Karaseva O.V.

State budgetary healthcare facility «Research Institute of Emergency Pediatric Surgery and Traumatology», Moscow Health Department, Moscow, Russian Federation

Arsenieva E.N.

Research Center of Children Нealth, Moscow

Lukyanov V.I.

Clinical and Research Institute of Emergency Children’s Surgery and Traumatology, Moscow Health Department, Moscow, Russia

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Asanov A.Yu.

Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia

Roshal' L.M.

Nauchno-issledovatel'skiĭ institut neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Pinelis V.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

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