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Kibitov A.O.

Serbsky National Medical Research Center for Psychiatry and Narcology

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Rakitko A.S.

Genotek Ltd

Kasyanov E.D.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Ilinsky V.V.

Genotek Ltd

Golimbet V.E.

Mental Health Research Center

Shmukler A.B.

Serbsky National Medical Research Center of Psychiatry and Narcology

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

GWAS-based polygenic risk scores for depression with clinical validation: methods and study design in the Russian population

Authors:

Kibitov A.O., Mazo G.E., Rakitko A.S., Kasyanov E.D., Rukavishnikov G.V., Ilinsky V.V., Golimbet V.E., Shmukler A.B., Neznanov N.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11): 131‑140

DOI: 10.17116/jnevro2020120111131

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To cite this article:

Kibitov AO, Mazo GE, Rakitko AS, et al. . GWAS-based polygenic risk scores for depression with clinical validation: methods and study design in the Russian population. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11):131‑140. (In Russ.)
https://doi.org/10.17116/jnevro2020120111131

 
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Depression is one of the leading causes of decreased quality of life and social functioning of patients. In the context of preventive medicine, the prevention of depression becomes a priority. To achieve the goals of prevention, it is necessary to identify specific population risk groups — individuals with a high genetic risk of depression. The paper describes the project aimed at developing a genetic test system based on polygenic risk scores (PRS) for depression, considering the multi-ethnicity and multicultural diversity of the Russian population. As a result of the study, data on the genetic architecture of depression (GWAS) and PRS for depression will be obtained for the first time. The emergence of a genetic test system developed in the study of the Russian population and in the conditions of a constant decrease in the cost of genetic research will allow an effective transition to preventive medicine in the area of mental health.

Keywords:

depression
genetic risks
polygenic risk scores
genome-wide association study
population study
prevention
preventive healthcare

Authors:

Kibitov A.O.

Serbsky National Medical Research Center for Psychiatry and Narcology

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Rakitko A.S.

Genotek Ltd

Kasyanov E.D.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Ilinsky V.V.

Genotek Ltd

Golimbet V.E.

Mental Health Research Center

Shmukler A.B.

Serbsky National Medical Research Center of Psychiatry and Narcology

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

Received:

26.05.2020

Accepted:

31.05.2020

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