The relationship between inflammation, cognitive disorders and neuroimaging data in schizophrenia

Ushakov V.L.

National Researh Center «Kurchatov Institute»;
Alekseev Mental-health Hospital No1

Malashenkova I.K.

National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia

Kostyuk G.P.

Alekseev Psychiatric Clinical Hospital No. 1

SPIN RSCI: 3424-4544
Scopus AuthorID: 57200081884
ORCID: 0000-0002-3073-6305

Zakharova N.V.

Alekseev Moscow Psychiatric Hospital No. 1

Krynskiy S.A.

National Research Center «Kurchatov Institute»

Kartashov S.I.

National Researh Center «Kurchatov Institute»

Ogurtsov D.P.

National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia

Bravve L.V.

Alekseev Moscow Psychiatric Hospital No. 1

Kaydan M.A.

Alekseev Mental-health Hospital No1

Hailov N.A.

National Research Center «Kurchatov Institute»

Chekulaeva E.I.

National Research Center «Kurchatov Institute»

Didkovsky N.A.

Federal and Clinical Center of PhysicalCchemical Medicine Russia

The relationship between inflammation, cognitive disorders and neuroimaging data in schizophrenia

Authors:

Ushakov V.L., Malashenkova I.K., Kostyuk G.P., Zakharova N.V., Krynskiy S.A., Kartashov S.I., Ogurtsov D.P., Bravve L.V., Kaydan M.A., Hailov N.A., Chekulaeva E.I., Didkovsky N.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11): 70‑78

DOI: 10.17116/jnevro202012011170

Read: 4205 times

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To cite this article:

Ushakov VL, Malashenkova IK, Kostyuk GP, et al. . The relationship between inflammation, cognitive disorders and neuroimaging data in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11):70‑78. (In Russ.)
https://doi.org/10.17116/jnevro202012011170

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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OBJECTIVE

To search for the relationship between the results of functional imaging, immunological parameters and laboratory markers of inflammation in schizophrenia, taking into account cognitive impairment in patients, and to consider the possibility of using a multidisciplinary approach to diagnosis, treatment and prognosis of schizophrenia.

MATERIAL AND METHODS

The study included 25 patients with schizophrenia and 13 healthy volunteers. Psychiatric scales were administered to evaluate the patient’s condition. The main indicators of humoral immunity, the level of markers of inflammation, key pro-inflammatory and anti-inflammatory cytokines, and growth factor VEGF were determined by ELISA. Brain MRI was performed. All calculated tractographic data are included in the connection database to study the effect of immunological markers and the degree of severity of cognitive impairment.

RESULTS AND CONCLUSION

Levels of markers of systemic inflammation and growth factor VEGF-A as well as the activation of humoral immunity are increased in patients with schizophrenia compared with controls. For the first time, the relationship of immunological parameters with the coefficient of quantitative anisotropy in the area of the corpus callosum in schizophrenia was revealed. The results indicate the possible value of indicators of the activation of the humoral immune response and systemic inflammation as markers of neurophysiological changes and cognitive dysfunction in schizophrenia.

Keywords:

corpus callosum

immunoglobulins

inflammation

interleukins

schizophrenia

cognitive impairment

tractography

Authors:

Ushakov V.L.

National Researh Center «Kurchatov Institute»;
Alekseev Mental-health Hospital No1

Malashenkova I.K.

National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia

Kostyuk G.P.

Alekseev Psychiatric Clinical Hospital No. 1

SPIN RSCI: 3424-4544
Scopus AuthorID: 57200081884
ORCID: 0000-0002-3073-6305

Zakharova N.V.

Alekseev Moscow Psychiatric Hospital No. 1

Krynskiy S.A.

National Research Center «Kurchatov Institute»

Kartashov S.I.

National Researh Center «Kurchatov Institute»

Ogurtsov D.P.

National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia

Bravve L.V.

Alekseev Moscow Psychiatric Hospital No. 1

Kaydan M.A.

Alekseev Mental-health Hospital No1

Hailov N.A.

National Research Center «Kurchatov Institute»

Chekulaeva E.I.

National Research Center «Kurchatov Institute»

Didkovsky N.A.

Federal and Clinical Center of PhysicalCchemical Medicine Russia

Received:

17.03.2020

Accepted:

13.04.2020

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