The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Ushakov V.L.
National Researh Center «Kurchatov Institute»;
Alekseev Mental-health Hospital No1
Malashenkova I.K.
National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia
Kostyuk G.P.
Alekseev Psychiatric Clinical Hospital No. 1
Zakharova N.V.
Alekseev Moscow Psychiatric Hospital No. 1
Krynskiy S.A.
National Research Center «Kurchatov Institute»
Kartashov S.I.
National Researh Center «Kurchatov Institute»
Ogurtsov D.P.
National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia
Bravve L.V.
Alekseev Moscow Psychiatric Hospital No. 1
Kaydan M.A.
Alekseev Mental-health Hospital No1
Hailov N.A.
National Research Center «Kurchatov Institute»
Chekulaeva E.I.
National Research Center «Kurchatov Institute»
Didkovsky N.A.
Federal and Clinical Center of PhysicalCchemical Medicine Russia
The relationship between inflammation, cognitive disorders and neuroimaging data in schizophrenia
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11): 70‑78
Read: 4205 times
To cite this article:
Ushakov VL, Malashenkova IK, Kostyuk GP, et al. . The relationship between inflammation, cognitive disorders and neuroimaging data in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry.
2020;120(11):70‑78. (In Russ.)
https://doi.org/10.17116/jnevro202012011170
To search for the relationship between the results of functional imaging, immunological parameters and laboratory markers of inflammation in schizophrenia, taking into account cognitive impairment in patients, and to consider the possibility of using a multidisciplinary approach to diagnosis, treatment and prognosis of schizophrenia.
The study included 25 patients with schizophrenia and 13 healthy volunteers. Psychiatric scales were administered to evaluate the patient’s condition. The main indicators of humoral immunity, the level of markers of inflammation, key pro-inflammatory and anti-inflammatory cytokines, and growth factor VEGF were determined by ELISA. Brain MRI was performed. All calculated tractographic data are included in the connection database to study the effect of immunological markers and the degree of severity of cognitive impairment.
Levels of markers of systemic inflammation and growth factor VEGF-A as well as the activation of humoral immunity are increased in patients with schizophrenia compared with controls. For the first time, the relationship of immunological parameters with the coefficient of quantitative anisotropy in the area of the corpus callosum in schizophrenia was revealed. The results indicate the possible value of indicators of the activation of the humoral immune response and systemic inflammation as markers of neurophysiological changes and cognitive dysfunction in schizophrenia.
Keywords:
Authors:
Ushakov V.L.
National Researh Center «Kurchatov Institute»;
Alekseev Mental-health Hospital No1
Malashenkova I.K.
National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia
Kostyuk G.P.
Alekseev Psychiatric Clinical Hospital No. 1
Zakharova N.V.
Alekseev Moscow Psychiatric Hospital No. 1
Krynskiy S.A.
National Research Center «Kurchatov Institute»
Kartashov S.I.
National Researh Center «Kurchatov Institute»
Ogurtsov D.P.
National Research Center «Kurchatov Institute»;
Federal and Clinical Center of PhysicalCchemical Medicine Russia
Bravve L.V.
Alekseev Moscow Psychiatric Hospital No. 1
Kaydan M.A.
Alekseev Mental-health Hospital No1
Hailov N.A.
National Research Center «Kurchatov Institute»
Chekulaeva E.I.
National Research Center «Kurchatov Institute»
Didkovsky N.A.
Federal and Clinical Center of PhysicalCchemical Medicine Russia
Received:
17.03.2020
Accepted:
13.04.2020
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.