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Barinov E.F.

Gorky Donetsk National Medical University

Statinova E.A.

Gorky Donetsk National Medical University

Sokhina V.S.

Gorky Donetsk National Medical University

Faber T.I.

Gorky Donetsk National Medical University

Risks of progression of cerebrovascular pathology associated with the activity of the brain purinergic system

Authors:

Barinov E.F., Statinova E.A., Sokhina V.S., Faber T.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10): 118‑124

DOI: 10.17116/jnevro2020120101118

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RISKS OF PROGRESSION OF CEREBROVASCULAR PATHOLOGY ASSOCIATED WITH THE ACTIVITY OF THE BRAIN PURINERGIC SYSTEM
RISKS OF PROGRESSION OF CEREBROVASCULAR PATHOLOGY ASSOCIATED WITH THE ACTIVITY OF THE BRAIN PURINERGIC SYSTEM

To cite this article:

Barinov EF, Statinova EA, Sokhina VS, Faber TI. Risks of progression of cerebrovascular pathology associated with the activity of the brain purinergic system. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10):118‑124. (In Russ.)
https://doi.org/10.17116/jnevro2020120101118

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
 
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Until now, there is no understanding of the relationship between risk factors and the progression of cerebrovascular pathology. The review presents facts that confirm the involvement of various subtypes of purine P2 receptors in neuron activation, growth and myelination of axons, migration and microglia phagocytosis, astrogliosis, regulation of vascular tone, thrombosis and angiogenesis, neuroinflammation and immune responses. The data suggest the possibility of the activation of purinergic system of the brain during the development of main risk factors for cerebrovascular pathology (age, arterial hypertension, diabetes), as a stereotypical mechanism that can affect the homeostasis of the ensemble “neuron-glia-capillary”. Purinergic P2 receptors may be a potential target for the development of pharmacological methods to limit the progression of cerebrovascular pathology.

Keywords:

cerebrovascular pathology
risk factors
purinergic system of the brain

Authors:

Barinov E.F.

Gorky Donetsk National Medical University

Statinova E.A.

Gorky Donetsk National Medical University

Sokhina V.S.

Gorky Donetsk National Medical University

Faber T.I.

Gorky Donetsk National Medical University

Received:

22.01.2020

Accepted:

23.01.2020

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