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Belkin A.A.

Clinical Institute of Brain

Leiderman I.N.

Clinical Institute of the Brain

Kovalenko A.L.

Central State Medical Academy of the Presidential Administration of the Russian Federation

Rizakhanova O.A.

North-Western State Medical University named after I.I. Mechnikov

Parfenov S.A.

North-Western Institute of Management

Sapozhnikov K.V.

North-West Institute of Management of RANEPA

Cytoflavin as a modulator of rehabilitation treatment of patients with ischemic stroke complicated by post-intensive care syndrome

Authors:

Belkin A.A., Leiderman I.N., Kovalenko A.L., Rizakhanova O.A., Parfenov S.A., Sapozhnikov K.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10): 27‑32

DOI: 10.17116/jnevro202012010127

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Table of contents

CYTOFLAVIN AS A MODULATOR OF REHABILITATION TREATMENT OF PATIENTS WITH ISCHEMIC STROKE COMPLICATED BY POST-INTENSIVE CARE SYNDROME
CYTOFLAVIN AS A MODULATOR OF REHABILITATION TREATMENT OF PATIENTS WITH ISCHEMIC STROKE COMPLICATED BY POST-INTENSIVE CARE SYNDROME

To cite this article:

Belkin AA, Leiderman IN, Kovalenko AL, Rizakhanova OA, Parfenov SA, Sapozhnikov KV. Cytoflavin as a modulator of rehabilitation treatment of patients with ischemic stroke complicated by post-intensive care syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10):27‑32. (In Russ.)
https://doi.org/10.17116/jnevro202012010127

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

To assess an effect of cytoflavin on the results of rehabilitation treatment and the increase in exercise tolerance in patients with stroke complicated by post-intensive care syndrome (PICS).

MATERIAL AND METHODS

The data of 53 patients who underwent neurorehabilitation in the ICU after ischemic stroke were analyzed. Depending on the treatment regimen, the patients were divided into two groups. Group 1 (main, n=36) received cytoflavin (iv drip in a volume of 10 ml of a solution for injections per 200 ml of a 0.9% solution of sodium chloride) for 10 days in addition to the complex of neurorehabilitation measures. Group 2 (control, n=17) included patients, who had only a standard set of neurorehabilitation measures for 10 days. The efficacy of the therapy was evaluated using indirect calorimetry, and the oxygen and energy load price index was calculated. To assess the tolerability of rehabilitation methods, a verticalization test was used. Treatment tolerance was assessed by the incidence of adverse reactions in each group.

RESULTS AND CONCLUSION

The components of the energytropic effect of cytoflavin can have a positive modulating effect, increasing the tolerance of rehabilitation measures for the treatment of PICS in patients with ischemic stroke. Further research is required.

Keywords:

neurorehabilitation
stroke
exercise tolerance
verticalization test
cytoflavin

Authors:

Belkin A.A.

Clinical Institute of Brain

Leiderman I.N.

Clinical Institute of the Brain

Kovalenko A.L.

Central State Medical Academy of the Presidential Administration of the Russian Federation

Rizakhanova O.A.

North-Western State Medical University named after I.I. Mechnikov

Parfenov S.A.

North-Western Institute of Management

Sapozhnikov K.V.

North-West Institute of Management of RANEPA

Received:

25.06.2020

Accepted:

01.07.2020

List of references:

  1. Pun BT, Balas MC, Barnes-Daly MA, Thompson JL, Aldrich JM, Barr J, Byrum D, Carson SS, Devlin JW, Engel HJ, Esbrook CL, Hargett KD, Harmon L, Hielsberg C, Jackson JC, Kelly TL, Kumar V, Millner L, Morse A, Perme CS, Posa PJ, Puntillo KA, Schweickert WD, Stollings JL, Tan A, D’Agostino McGowan L, Ely EW. Caring for Critically Ill Patients With the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000. AdultsCrit Care Med. 2019 Jan;47(1):3-14.  https://doi.org/10.1097/CCM.0000000000003482
  2. Belkin AA. Syndrome of the consequences of intensive care (pit syndrome). Vestnik intensivnoj terapii im. A.I. Saltanova. 2018;2:12-23. (In Russ). https://doi.org/10.21320/1818-474X-2018-2-12-23
  3. Belkin AA, Alasheev AM. Neyromyishechnyie rasstroystva. Natsionalnoe rukovodstvo po intensivnoy terapii. T.1. M. 2009;357-360. (In Russ).
  4. Balocchi R, Di Garbo A, Michelassi C, Chillemi S, Varanini M, Barbi M, Legramante JM, Raimondi G, Zbilut JP: Heart rate and blood pressure response to short-term head-down bed rest: a nonlinear approach. Methods Inf Med. 2000; 39:157-159. 
  5. Bel kin AA, Alasheev AM, Davyidova NS, Levit AL, Khalin AV. Basing for emergency rehabilitation in the prevention and treatment of «post intensive care» syndrome (PIC syndrome). Vestnik vosstanovitel noy meditsinyi. 2014;1:37-43. (In Russ).
  6. Lan Zhang, Weishu Hu, Zhiyou Cai, Jihong Liu, Jianmei Wu, Yangmin Deng, Keping Yu, Xiaohua Chen, Li Zhu, Jingxi Ma, Yan Qin. Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis. Plos One. 2019 Oct 3;14(10):e0223185. https://doi.org/10.1371/journal.pone.0223185
  7. Antonov AG, Burkova AS, Im VL, Rogatkin SO. Efficiency of using cytoflavin in intensive therapy of premature neonates with cerebral ischemia Rossijskij vestnik perinatologii i pediatrii. 2010;55(1):26-32. (In Russ).
  8. Romantsov MG, Kovalenko AL, Suslina ZA, Klocheva EG, Rumyantseva SA, Bagnenko SF. Pharmacotherapeutic efficacy of Cytoflavin in intensive care of life-threatening conditions (clinical review). Profilakticheskaya i klinicheskaya meditsina. 2009;2:125-133. (In Russ).
  9. Patent RU No. 2497447. A method for assessing the tolerability of rehabilitation methods in patients with acute cerebral insufficiency. (In Russ). https://findpatent.ru/patent/260/2607161.html
  10. Belkin AA, Alasheev AM, Davydova NS, Lejderman IN, Pochepko DV, Khalin AV. Gravity gradient in bed-rest mode in patients with acute cerebral insufficiency. Vestnik Ural’skoj meditsinskoj akademicheskoj nauki. 2015;1(52):22-28. (In Russ).
  11. Verticalization of patients during rehabilitation. Clinical recommendations. M., 2014. (In Russ). https://rehabrus.ru/Docs/Protokol_Vertikalizaciya.pdf

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