Objective. To study neurophysiological processes during multichannel electrostimulation in patients with depressive disorder. Material and methods. The study involved 6 patients with depressive disorder (F33). The technology noninvasive multichannel stimulation of neck neural struct SYMPATHOKOR-01 device. Clinical and psychometric methods, functional neuroimaging (fMRTP) and multichannel electroencephalography (EEG) were used to assess treatment effect. Results. In all patients, fMRTP and EEG results show the disturbances of brain connectivity, which are correlated with the clinical state of the disease, before treatment. After five stimulation procedures, there is an increase in functional connection of the medial prefrontal cortex (according to rs-fMRI results) and an increase in the synchronization of various parts of the cortex (EEG results). Conclusion. The results demonstrate the possibilities of multichannel electrical stimulation of the neck nervous structures to restore the intracerebral connections disturbed during depression due to the activation of neuroplasticity.