Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome

Esipov A.V.

Visnevsky 3rd Central Military Clinical Hospital, Krasnogorsk, Moscow Region, Russia

Ivolgin A.F.

Visnevsky 3rd Central Military Clinical Hospital, Krasnogorsk, Moscow Region, Russia

Khritinin D.F.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Pervogo moskovskogo meditsinskogo universiteta im. I.M. Sechenova;
Kafedra psikhiatrii Riazanskogo gosudarstvennogo meditsinskogo universiteta im. akad. I.P. Pavlova

Katenko S.V.

GBOU VPO Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Kazakov S.P.

Burdenko Main Military Clinical Hospital, Ministry of Defense, Moscow, Russia;
Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Karakozov A.G.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Kalyagin I.E.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Levchenko O.B.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Molodova A.I.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome

Authors:

Esipov A.V., Ivolgin A.F., Khritinin D.F., Katenko S.V., Kazakov S.P., Karakozov A.G., Kalyagin I.E., Levchenko O.B., Molodova A.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(9): 46‑51

DOI: 10.17116/jnevro201911909146

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To cite this article:

Esipov AV, Ivolgin AF, Khritinin DF, et al. . Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(9):46‑51. (In Russ.)
https://doi.org/10.17116/jnevro201911909146

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Objective. To analyze the efficacy of cytoflavin in the complex treatment of sleep disorders in asthenic syndrome. Material and methods. One hundred patients with sleep disorders and asthenic syndrome of various etiology and severity were studied. The patients were divided into three groups depending on the type of therapy: the first group received intravenous infusions of cytoflavin for 10 days; the second group, in addition to cytoflavin, received per os melatonin (3 mg or 5 mg) at bedtime; the third group in addition to cytoflavin received per os zopiclone (7.5 mg) at bedtime. Results. On the 14th day of the study, a decrease in severity or complete relief of asthenia manifestations (according to the SHAS scale) and, accordingly, improvement or normalization of sleep in 97% of patients was found. At the same time, during polysomnographic study, the data obtained are characteristic for improving the quality of sleep phases mainly in the first and second groups of patients and, to a lesser extent, in the third group. Conclusion. Cytoflavin effectively suppresses the main manifestations of asthenic syndrome, including sleep disorders.

Keywords:

asthenic syndrome

asthenia

chronic fatigue syndrome

sleep disturbance

insomnia

cytoflavin

melatonin

zopiclone

Authors:

Esipov A.V.

Visnevsky 3rd Central Military Clinical Hospital, Krasnogorsk, Moscow Region, Russia

Ivolgin A.F.

Visnevsky 3rd Central Military Clinical Hospital, Krasnogorsk, Moscow Region, Russia

Khritinin D.F.

Katenko S.V.

GBOU VPO Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Kazakov S.P.

Burdenko Main Military Clinical Hospital, Ministry of Defense, Moscow, Russia;
Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Karakozov A.G.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Kalyagin I.E.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Levchenko O.B.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

Molodova A.I.

Evdokimov Moscow State Medical Dentistry University, Moscow, Russia

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