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Gultyaeva V.V.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Zinchenko M.I.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Uryumtsev D.Y.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Krivoschekov S.G.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Aftanas L.I.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Exercise for depression treatment. Physiological mechanisms

Authors:

Gultyaeva V.V., Zinchenko M.I., Uryumtsev D.Y., Krivoschekov S.G., Aftanas L.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(7): 112‑119

DOI: 10.17116/jnevro2019119071112

Read: 13250 times

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Table of contents

EXERCISE FOR DEPRESSION TREATMENT. PHYSIOLOGICAL MECHANISMS
EXERCISE FOR DEPRESSION TREATMENT. PHYSIOLOGICAL MECHANISMS

To cite this article:

Gultyaeva VV, Zinchenko MI, Uryumtsev DY, Krivoschekov SG, Aftanas LI. Exercise for depression treatment. Physiological mechanisms. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(7):112‑119. (In Russ.)
https://doi.org/10.17116/jnevro2019119071112

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

This literature review considers meta-analyzes, systematic reviews and original research over the last decade addressing a comprehensive analysis of the antidepressant effect of targeted physical exercise and physical activity in general. Exercise is a promising non-pharmacological treatment for depression, showing effects that are comparable or may even exceed other first-line treatments of depression. The article introduces modern ideas about the mechanisms of depression and mechanisms of exercise effects on depression manifestations. The structures of the central nervous system, changing with the effective exercise-based treatment of depression, are indicated. Physical activity stimulates the secretion of growth factors, maintenance of angio-, synapto-, and neurogenesis. The regulation of antioxidant protection of neuronal mitochondria, a decrease in pro-inflammatory reactions and stress reactivity are also observed in response to regular exercise. Physical activity has a multimodal effect that stimulates biochemical pathways and restores neuronal structures disturbed in depression.

Keywords:

exercise
physical activity
depression
neurogenesis
BDNF
energy metabolism

Authors:

Gultyaeva V.V.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Zinchenko M.I.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Uryumtsev D.Y.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Krivoschekov S.G.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

Aftanas L.I.

Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

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