Cerebrolysin peptides as mood stabilizers

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Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

ORCID: 0000-0002-7663-710X

Zgoda V.G.

Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

Tikhonova O.V.

Endocrinology Research Centre, Moscow, Russia

Malyavskaya S.I.

SevGMU 'Northern State Medical University' of the Ministry of Health of Russia, Arkhangelsk, Russia

Cerebrolysin peptides as mood stabilizers

Authors:

Torshin I.Iu., Gromova O.A., Zgoda V.G., Tikhonova O.V., Malyavskaya S.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12): 69‑75

DOI: 10.17116/jnevro201911912169

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To cite this article:

Torshin IIu, Gromova OA, Zgoda VG, Tikhonova OV, Malyavskaya SI. Cerebrolysin peptides as mood stabilizers. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12):69‑75. (In Russ.)
https://doi.org/10.17116/jnevro201911912169

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Objective. To establish the molecular mechanisms of the mood stabilizing (normothymic) action of the neuroprotector Cerebrolysin. Material and methods. Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized. Results. Cerebrolysin contains considerable amounts of Leu- and Met-enkephalins, partial analogues of enkephalins, peptide fragments of beta-lipotropin. These peptides stimulate the endorphinergic system thus contributing to normothymic action and an increase in the levels of the brain-derived neurotrophic factor (BDNF). Specific inhibition of kinases ABL1, PINK1, CDK5 and arginine N-methyltransferase PRMT5 by the peptides of cerebrolysin has a multidirectional effect on the dopaminergic system, also helping to stabilize mood. Cerebrolysin peptides do not directly affect neither the serotonergic, adrenergic, nor GABAergic systems. Conclusions. The normothymic effect of Cerebrolysin is due to the stabilization of endorphinergic and dopaminergic neurotransmission.

Keywords:

enkephalins

dopamine

neuroprotectors

bioinformatics

cerebrolysin

Authors:

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

ORCID: 0000-0002-7663-710X

Zgoda V.G.

Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

Tikhonova O.V.

Endocrinology Research Centre, Moscow, Russia

Malyavskaya S.I.

SevGMU 'Northern State Medical University' of the Ministry of Health of Russia, Arkhangelsk, Russia

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