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Pirozhkov S.V.

Sechenov First Moscow State Medical University of the MH, Moscow, Russia

Terebilina N.N.

Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Litvitsky P.F.

Chair of Hospital-Based Therapy №2, Chair of Pathophysiology of Medical Faculty, Sechenov First Moscow State Medical University of Ministry of Health of Russia, Moscow, Russia

A role of inflammasomes in the pathogenesis of neurological and mental diseases

Authors:

Pirozhkov S.V., Terebilina N.N., Litvitsky P.F.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12): 81‑91

DOI: 10.17116/jnevro201811812181

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A ROLE OF INFLAMMASOMES IN THE PATHOGENESIS OF NEUROLOGICAL AND MENTAL DISEASES
A ROLE OF INFLAMMASOMES IN THE PATHOGENESIS OF NEUROLOGICAL AND MENTAL DISEASES

To cite this article:

Pirozhkov SV, Terebilina NN, Litvitsky PF. A role of inflammasomes in the pathogenesis of neurological and mental diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12):81‑91. (In Russ.)
https://doi.org/10.17116/jnevro201811812181

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
 
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Inflammasomes are macromolecular complexes that contain many copies of receptors recognizing molecular patterns of pathogenic agents (PAMP) and damage-associated structures (DAMP), and also include molecules of adapter protein ASC and procaspase-1. Activation of inflammasomes leads to the formation of active caspase-1 that, in turn, provides the maturation of pro-IL-1β and pro-IL-18 to IL-1β and IL-18. The latter cytokines play an important role in control of neuroinlfammation in the central nervous system contributing to the pathogenesis of a series of neurological, neurodegenerative and mental disorders. The review discusses the involvement of NLRP3 inflammasome and other their types in the development of the traumatic brain injury, ischemic and hemorrhagic stroke, brain tumors, CNS infections, Alzheimer’s and Parkinson’s diseases, epilepsy, amyotrophic lateral sclerosis, depressiver, and consequences of alcohol abuse. The elucidation of molecular mechanisms and signaling pathways controlled by inflammasomes will allow the development of new therapeutic measures for diseases, in which neuroinflammation plays a leading pathogenetic role.

Keywords:

NLRP3-inflammasome
IL-1β
IL-18
traumatic brain injury
stroke
brain tumor
Alzheimer’s disease
Parkinson’s diseases
depressive disorder

Authors:

Pirozhkov S.V.

Sechenov First Moscow State Medical University of the MH, Moscow, Russia

Terebilina N.N.

Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Litvitsky P.F.

Chair of Hospital-Based Therapy №2, Chair of Pathophysiology of Medical Faculty, Sechenov First Moscow State Medical University of Ministry of Health of Russia, Moscow, Russia

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