The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kotov S.V.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Isakova E.V.

Lizhdvoĭ V.Iu.

Belova Iu.A.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Volchenkova T.V.

M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia

Borodin A.V.

Kafedra obshcheĭ khirurgii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Shvedov V.A.

Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia

The efficacy of cocarnit in diabetic neuropathy

Authors:

Kotov S.V., Isakova E.V., Lizhdvoĭ V.Iu., Belova Iu.A., Volchenkova T.V., Borodin A.V., Shvedov V.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(1): 37‑42

DOI: 10.17116/jnevro20181181137-42

Read: 5900 times

Download PDF (RU)
Contact the author
Table of contents

THE EFFICACY OF COCARNIT IN DIABETIC NEUROPATHY
THE EFFICACY OF COCARNIT IN DIABETIC NEUROPATHY

To cite this article:

Kotov SV, Isakova EV, Lizhdvoĭ VIu, Belova IuA, Volchenkova TV, Borodin AV, Shvedov VA. The efficacy of cocarnit in diabetic neuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(1):37‑42. (In Russ.)
https://doi.org/10.17116/jnevro20181181137-42

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Possibilities of using meldonium as part of complex therapy in patients with ischemic heart disease and chro­nic heart failure combined with obesity. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(1):53-60
Clinical effi­cacy of high-intensity magnetic therapy and transcutaneous electrical nerve stimulation in patients with diabetes mellitus and distal poly­neuropathy: a randomized study. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2025;(1):5-11
Effi­cacy and safety of mome­tasone and olopatadine combination for nasal use in patients with alle­rgic rhinitis caused by sensitization to epidermal alle­rgens in continuous expo­sure. Russian Rhinology. 2025;(1):48-56
Treatment of acute hemo­rrhoids acco­rding to the resu­lts of a multicenter obse­rvational study. Piro­gov Russian Journal of Surgery. 2025;(3):112-123
Vali­dation of the Russian version of the Caro­linas Comfort Scale in patients after previous abdo­minal hernia repair with mesh. Piro­gov Russian Journal of Surgery. 2025;(4):30-30
Prediction and prevention of burnout syndrome in health care professionals in high epidemic risk settings. Russian Journal of Preventive Medi­cine. 2025;(4):51-56
The effect of a gami­fication on healthy indi­viduals’ motor acti­vity. Russian Journal of Preventive Medi­cine. 2025;(4):111-116
Analysis of the oral health-related quality of life among school children and young adults before and after orthodontic treatment. Stomatology. 2025;(2):54-58
Late complications and quality of life after multivisceral surgeries with pancreatoduodenectomy. Piro­gov Russian Journal of Surgery. 2025;(7):36-45
Key specific tools for asse­ssment of life quality of patients with psoriasis. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(3):319-325
Abstract:

Objective. To study the efficacy of the complex therapy, including cocarnit (group B vitamins, triphosadenine and nicotinamide), of diabetic neuropathy. Material and methods. Forty-one patients with diabetes mellitus type 2 and distal symmetric sensorimotor polyneuropathy were examined. Patients were divided into 2 groups. Patients of the main group (n=26) received complex therapy, including cocarnit, and patients of the comparison group (n=15) received standard treatment. Results and conclusion. The positive dynamics based on the VAS (р=0.0001), TSS (р=0.0001), NSS (р=0.001), NDS (р=0.0431), SF-36 (р=0.0008), electroneuromyographic results and glycated hemoglobin levels was observed in the main group. In patients of the comparison group, the positive dynamics was instable; the scores of clinical scales did not reach statistical significance. The results suggest the use of cocarnit in the complex treatment of patients with diabetic neuropathy.

Keywords:

diabetic neuropathy
quality of life
group B vitamins
cocarnit

Authors:

Kotov S.V.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Isakova E.V.

Lizhdvoĭ V.Iu.

Belova Iu.A.

Moskovskiĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Volchenkova T.V.

M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia

Borodin A.V.

Kafedra obshcheĭ khirurgii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Shvedov V.A.

Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia

Close metadata

References:

  1. Maffi P, Secchi A. The Burden of Diabetes: Emerging Data. Dev Ophthalmol. 2017;60:1-5. https://doi.org/10.1159/000459641
  2. da Rocha Fernandes J, Ogurtsova K, Linnenkamp U, Guariguata L, Seuring T, Zhang P, Cavan D, Makaroff LE. IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes. Diabetes Res Clin Pract. 2016;117:4854. https://doi.org/10.1016/j.diabres.2016.04.016
  3. Juster-Switlyk K, Smith AG. Updates in diabetic peripheral neuropathy. F1000Res. 201625;5:1000:738. https://doi.org/10.12688/f1000research.7898.1
  4. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med. 2007;356(3):213-215. https://doi.org/10.1056/nejmp068177
  5. Kotov SV, Rudakova IG, Isakova EV, Volchenkova TV. Diabetic neuropathy: a variety of clinical forms (а lecture). RMZh. 2017;25(11):822-830. (In Russ.)
  6. Kotov SV, Rudakova IG, Isakova EV, Volchenkova TV. Modern approaches to the diagnosis and treatment of polyneuropathy in diabetes (a lecture). RMZh. 2016;24(24):1620-1626. (In Russ.)
  7. Maffi P, Secchi A. The Burden of Diabetes: Emerging Data. Dev Ophthalmol. 2017;60:1-5. https://doi.org/10.1159/000459641
  8. Kozyaikin VV, Isakova EV. Modifiable risk factors of the stroke in patients of a small town. Almanac of Clinical Medicine. 2016;44(3):287-294. (InRuss.)
  9. Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol. 2012;11(6):521-534. https://doi.org/10.1016/S1474-4422(12)70065-0
  10. Popescu S, Timar B, Baderca F, Simu M, Diaconu L, Velea I, Timar R. Age as an independent factor for the development of neuropathy in diabetic patients. Clin Interv Aging. 2016;11:313-318. https://doi.org/10.2147/CIA.S97295
  11. Kotov SV, Rudakova IG, Isakova EV, Belova YuA, Volchenkova TV, Kkhirbek M, Stashuk GA. Diabetic asymmetric proximal neuropathy. Zhurnal nevrologii I psikhiatrii im. C.C. Korsakova. 2017;117(1): 59-62. (In Russ.) https://doi.org/10.17116/jnevro20171171159-62
  12. Isakova EV, Kotov SV. Correction of hypercholesterolemia, hyperglycemia and obesity are important components of primary prevention of stroke. RMZh. 2014;22(10):707-710. (In Russ.)
  13. Kotov AS, Eliseev YuV. Diabetic polyneuropathy and diabetic foot syndrome. Effektivnaya farmakoterapiya. 2013;48:32-39. (InRuss.)
  14. Kotov AS, Eliseev YuV. Modern views on the treatment of diabetic polyneuropathy. Effektivnaya farmakoterapiya. 2012;49:58-61 (In Russ.)
  15. Fullerton B, Jeitler K, Seitz M, Horvath K, Berghold A, Siebenhofer A. Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus. Cochrane Database Syst Rev. 2014;(2). https://doi.org/10.1002/14651858.cd009122.pub2
  16. Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassaï B, Erpeldinger S, Wright JM, Gueyffier F, Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ. 2011;343:4169. https://doi.org/10.1136/bmj.d4169
  17. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28(2):103-117. https://doi.org/10.1016/0168-8227(95)01064-k
  18. Kotov AS. Diabetic polyneuropathy: a literature review. Effektivnaya farmakoterapiya. 2011;50:44-48 (In Russ.)
  19. Kotov SV, Rudakova IG, Isakova EV. Encephalopathy in patients with diabetes mellitus type II. Clinic and treatment. Nevrologicheskii zhurnal. 2001;3:35. (In Russ.)
  20. Kotov SV, Isakova EV, Belova YuA, Zmyslinski AV, Kolchu IG, Kucheryavaya MV, Pustinnikov YaA, Smetana LV, Sashin VV, Chernih NP. Systemic thrombolytic therapy of ischemic stroke in diabetes mellitus type 2 and hyperglycemia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(12-2):36-40. (InRuss.) https://doi.org/10.17116/jnevro201611612236-40
  21. Volchenkova TV, Kolchu IG, Isakova EV, Kotov SV. Uglevodnyi obmen u bol’nykh s tserebral’nym insul’tom. Byulleten’ sibirskoi meditsiny. 2010;9(4):35-37. (InRuss.)
  22. Khanam PA, Hoque S, Begum T, Habib SH, Latif ZA. Microvascular complications and their associated risk factors in type 2 diabetes mellitus. Diabetes Metab Syndr. 2017;1871-4021(17)30074-30077. https://doi.org/10.1016/j.dsx.2017.04.007
  23. Bulum T, Blaslov K, Duvnjak L. The use of antropometric measurements of obesity in prediction of microvascular complications in obese type 2 diabetic patients. Acta Clin Croat. 2016;55(2):217-223. https://doi.org/10.20471/acc.2016.55.02.06
  24. Caram-Salas NL, Reyes-García G, Medina-Santillán R, Granados-Soto V. Thiamine and cyanocobalamin relieve neuropathic pain in rats: synergy with dexamethasone. Pharmacology. 2006;77(2):53-62. https://doi.org/10.1159/000092643
  25. Zhuravleva MV, Shikh EV, Makhova AA. A relationship between analgesic and neurotropic effects by the example of milgamma. Ter Arkh. 2012;84(12):131-134.
  26. Alvarado MA, Navarro AS. Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy. J Diabetes Res. 2016;2016:4078695. https://doi.org/10.1155/2016/4078695
  27. Niafar M, Hai F, Porhomayon J, Nader ND. The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med. 2015;10(1):93-102. https://doi.org/10.1007/s11739-014-1157-5
  28. Devlikamova F.I. The use of cocarinate in the treatment of patients with diabetic polyneuropathy Zhurnal nevrologii I psikhiatrii im. S.S. Korsakova. 2016;116(11):64-68 (In Russ.) https://doi.org/10.17116/jnevro201611611164-68
  29. Callaghan BC, Little AA, Feldman EL, Hughes RA. Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane Database Syst Rev. 2012;(6):CD007543. https://doi.org/10.1002/14651858.cd007543.pub2
  30. Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003;9(3):294-299. https://doi.org/10.1038/nm834
  31. Zhang Q, Li S, Li L, Li Q, Ren K, Sun X, Li J. Metformin Treatment and Homocysteine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016;8(12):798. https://doi.org/10.3390/nu8120798
  32. Niafar M, Hai F, Porhomayon J, Nader ND. The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med. 2015;10(1): 93-102. https://doi.org/10.1007/s11739-014-1157-5
  33. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008;116(10):600-605. https://doi.org/10.1055/s-2008-1065351
  34. WHO Model List of essential Medicines. 16th edition. World Health Organization; Mar, 2009.
  35. Chapman LE, Darling AL, Brown JE. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab. 2016;42(5):316-327. https://doi.org/10.1016/j.diabet.2016.03.008
  36. Várkonyi T, Körei A, Putz Z, Martos T, Keresztes K, Lengyel C, Nyiraty S, Stirban A, Jermendy G, Kempler P. Advances in the management of diabetic neuropathy. Minerva Med. 2017;108(5):419-437. https://doi.org/10.23736/S0026-4806.17.05257-0
  37. Ang CD, Alviar MJ, Dans AL, Bautista-Velez GG, Villaruz-Sulit MV, Tan JJ, Co HU, Bautista MR, Roxas AA. Vitamin B for treating peripheral neuropathy. Cochrane Database Syst Rev. 2008;(3):CD004573. https://doi.org/10.1002/14651858.cd004573.pub3
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.