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Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Karneev A.N.

Chekanov A.V.

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

Shchelkonogov V.A.

Pirogov Russian National Research Medical University, Moscow, Russia;
Moscow Technological University, Moscow, Russia

Sinebryukhova A.M.

Moscow Technological University, Moscow, Russia

Farakhova K.I.

Pirogov Russian National Research Medical University, Moscow, Russia

Sorokoumova G.M.

Moscow Technological University, Moscow, Russia

The study of the membrane-protective potential of the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline

Authors:

Solov'eva É.Iu., Karneev A.N., Chekanov A.V., Baranova O.A., Shchelkonogov V.A., Sinebryukhova A.M., Farakhova K.I., Sorokoumova G.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(1): 18‑22

DOI: 10.17116/jnevro20181181118-22

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Table of contents

THE STUDY OF THE MEMBRANE-PROTECTIVE POTENTIAL OF THE COMBINATION OF 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE-SUCCINATE AND CITICOLINE
THE STUDY OF THE MEMBRANE-PROTECTIVE POTENTIAL OF THE COMBINATION OF 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE-SUCCINATE AND CITICOLINE

To cite this article:

Solov'eva ÉIu, Karneev AN, Chekanov AV, et al. The study of the membrane-protective potential of the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(1):18‑22. (In Russ.)
https://doi.org/10.17116/jnevro20181181118-22

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective. To assess the changes in the composition of plasma phospholipids in patients with chronic cerebrovascular disease treated with neuroprotectors 2-ethyl-6-methyl-3-hydroxypyridine succinate (neurox) and citicoline (neipilept), the natural metabolites involved in biochemical processes in the body, and their composition. Material and methods. The study included 40 patients, 18 men and 22 women, aged from 54 to 72 years, with chronic cerebrovascular disease at the decompensation stage complicated with the hypertensive crisis and/or arrhythmia. Results and conclusion. During extraction of phospholipids from blood cells, a significant decrease in the amount of total lipids was found to the end of treatment of patients who received neurox or neipilept or their combination. The study of quantitative composition of phospholipids showed no significant changes in patients treated with neurox, while the use of citicoline or combination of citicoline with 2-ethyl-6-methyl-3-hydroxypyridine succinate resulted in the increase of their total mass. There were no significant changes in the qualitative composition of phospholipid classes in blood plasma in patients treated with neurox. In patients treated with neipilept or with the combination of citicoline with 2-ethyl-6-methyl-3-hydroxypyridine succinate, plasma phosphatidylcholine was significantly increased. No significant changes in the content of phosphatidylinositol, phosphatidylserine and sphingomyelin were observed.

Keywords:

brain ischemia
stroke
phospholipids
phosphatidylcholine
free radicals
citicoline
2-ethyl-6-methyl-3-hydroxypyridine succinate

Authors:

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Karneev A.N.

Chekanov A.V.

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

Shchelkonogov V.A.

Pirogov Russian National Research Medical University, Moscow, Russia;
Moscow Technological University, Moscow, Russia

Sinebryukhova A.M.

Moscow Technological University, Moscow, Russia

Farakhova K.I.

Pirogov Russian National Research Medical University, Moscow, Russia

Sorokoumova G.M.

Moscow Technological University, Moscow, Russia

Close metadata

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