Neurotropic effect of B vitamins in the complex treatment of pain syndrome

doi:https://doi.org/10.17116/jnevro201711791118-123

Close metadata

Recommended articles:

Early diagnosis and effective therapy of diabetic polyneuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):62-68

Comparative study of the efficacy and safety of combined therapy with lornoxicam (Xefokam Rapid) and a nucleotide complex Xefomielyn in patients with exacerbation of chronic nonspecific low back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):89-97

Contemporary concepts of the rational use of centrally acting skeletal muscle relaxants in the treatment of vertebrogenic dorsalgia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):154-160

Comparative analysis of the effectiveness of modern physiotherapeutical methods of dorsalgia treatment. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(2):35-44

Intraneural ganglion of the peroneal nerve: a case report and review. Russian Journal of Pain. 2025;(3):66-72

Deep endometriosis — a comparative study of pain syndrome and the prevalence of clinical symptoms according to the #ENZIAN classification. Russian Journal of Human Reproduction. 2025;(4):96-101

Rehabilitation of patients with vertebrogenic muscular-tonic and radicular syndromes. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(6):13-18

Early and late outcomes of retroperitoneal thoracophrenolumbotomy healing following open repair of thoracoabdominal aortic aneurysm and mega-aortic syndrome: a 15-year single-center experience. Russian Journal of Cardiology and Cardiovascular Surgery. 2026;(2):5-13

Electroneuromyography with bipolar stimulation probe for intercostal nerve cryoablation after thoracoabdominal aortic aneurysm and mega aorta repair. Russian Journal of Cardiology and Cardiovascular Surgery. 2026;(2):14-21

Nerve fibers in endometriosis: pain pathogenesis and new approaches to diagnosis. Russian Journal of Human Reproduction. 2026;(2):54-62

Abstract:

Combined vitamin preparations in therapeutic doses are used, along with simple analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), muscle and epidural blockade, for the relief of acute pain. It is recommended to use the B vitamin preparation neuromultivit. The tablet form of this preparation contains vitamin thiamine hydrochloride (100 mg), pyridoxine hydrochloride (200 mg), cyanocobalamin (0.2 mg), and injectable form includes thiamine hydrochloride (100mg), pyridoxine hydrochloride (100 mg), cyanocobalamin (1 mg). The efficacy of neuromultivit in a two stage scheme (intramuscular injections of 2 ml daily for 5—10 days with further injections 2—3 times a week for 2—3 weeks at the initial stage and 1 tablet 3 times a day for 4 weeks at the second stage) was shown.

Keywords:

pain syndrome

B vitamins

neuromultivit

dorsalgia

neuropathy

Close metadata

References:

Nikiforov AS, Konovalov AN, Gusev EI. Pain. In: Clinical Neurology. M.: Medicine; 2002. (In Russ.).
Solov’eva EYu. Therapy for back pain syndrome. Neurology, neuropsychiatry, psychosomatics. 2012;2:96-99. (In Russ.). https://doi.org/10.14412/2074-2711-2012-393
Roch-Gonzalez HI, Teran-Rosales F, Reyes-Garcia G, Medina-Santillán R, Granados-Soto V. B vitamins increase the analgetic effect of diclofenac in the rat. Proc West Pharmacol Soc. 2004;47:84-87.
Morozova TE, Durnetsova OS. B vitamins in clinical practice. Medical advice. 2014;18:72-77. (In Russ.).
Kurushina OV, Barulin AE. Polyneuropathy in somatic diseases: the role of the neurologist in the diagnosis and treatment. RMJ. 2013;36:1843. (In Russ.).
Ametov AS, Soluyanova TN. The role of B vitamins in the treatment of diabetic polyneuropathy. Medical advice. 2010;7:18-20. (In Russ.).
Gratsianskaya AN. Neuromultivit in the treatment of polyneuropathy. Pharmateca. 2007;15:37-41. (In Russ.).
Strokov IA. Back pain: therapy B vitamins. RMJ. 2010;25:1509-1514. (In Russ.).
Song XS, Huang ZJ, Song XJ. Thiamine suppressed thermal hyperalgesia, inhibits hyperexitability, and lessens alterations of sodium currents in injured, dorsal root ganglion neurons in rats. Anesthesiology. 2009;110(2):387-400. https://doi.org/10.1097/aln.0b013e3181942f1e
Caram-Salas NL, Reyes-Garcia G, Medina-Santillian R, Granados-Soto V. Thiamine and cyanocobalamin relieve neuropathic pain in rats: synergy with dexamethasone. Pharmacology. 2006;77(2):53-62. https://doi.org/10.1159/000092643
Mixcoatl-Zecuatl T, Quinonez-Bastidas GN, Caram-Salas NL, Ambriz-Tututi M, Araiza-Saldana CI, Rocha-Gonzalez HI, Medina-Santillan R, Reyes-Garcia G, Granados-Soto V. Synergistic antiallodinic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. Methods Find Exp Clin Pharmacol. 2008;30(6):431-441. https://doi.org/10.1358/mf.2008.30.6.1254247
Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. Life Sci. 2012;91(23-24):1187-1195. https://doi.org/10.1016/j.lfs.2012.08.025
Hosseinzadeh H, Moallem SA, Moshiri M, Sarnavazi M, Etemad L. Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B₁₂) against acute and chronic pain and inflammation in mice. Arzneimittelforschung. 2012;62(7):324-329. https://doi.org/10.1055/s-0032-1311635
Instructions for medical use of the drug Neuromultivit. Available at: https://www.rlsnet.ru/tn_index_id_1643.htm (In Russ.).
Vyalov SS. Patients with lumbar neuralgia: especially the treatment of lumbar syndrome. Directory of outpatient physician. 2013;12:16-22. (In Russ.).
Shavlovskaya OA. Some aspects of dorsalgia treatment. Consilium medicum. 2014;16(2):36-40. (In Russ.).
Umarova KhYa. Chronic pain syndromes — the use of neurotropic vitamins. Directory of outpatient physician. 2013;10:48-50. (In Russ.).
Golovacheva VA, Strokov IA. Treatment of diabetic and alcoholic polyneuropathy: opportunities and prospects for pharmacotherapy. RMJ. 2014;16:1193-1197. (In Russ.).
Kutsemelov IB, Berkut OA, Kushnareva VV, Postnikova AS. Algorithms and clinical guidelines for use of the drug Neuromultivit in neurological practice. RMJ. 2014;31:2186-2190. (In Russ.).
Manusharova RA, Cherkezov DI. The use of Neuromultivit in diabetic peripheral polyneuropathy. Medical advice. 2011;1-2:68-71. (In Russ.).
Tokmakova AYu, Antsiferov MB. The possibility of using Neuromultivit in complex therapy of polyneuropathy in patients with diabetes. Diabetes. 2001;11(2):33-35. (In Russ.).
Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, Nunes CP, Oliveira LB, da Fonseca AS. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25(11):2589-2599. https://doi.org/10.3111/13696990903246911
Mibielli MA, Nunes CP, Scussel JrAB, Neto MS, Oliveira L, Geller M. Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin. Pain Studies and Treatment. 2014;2(1):6-10. https://doi.org/10.4236/pst.2014.21002
Geller M, Mibielli MA, Nunes CP, da Fonseca A de S, Goldberg SW, Oliveira L. Impact of low back pain on Quality of Life: assessment by patient functionality questionnaire and treatment results using a combination of Diclofenac plus B vitamins or Diclofenac monotherapy. International Journal of Clinical Medicine. 2016;7:113-119. https://doi.org/10.4236/ijcm.2016.72012
Ponce-Monter HA, Ortiz MI, Garza-Hernández AF, Monroy-Maya R, Soto-Ríos M, Carrillo-Alarcón L, Reyes-García G, Fernández-Martínez E. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery. Pain Res Treat. 2012;104782. https://doi.org/10.1155/2012/104782
Levin OS, Moseikin IA. Vitamin B complex (Milgamma) for the treatment of vertebrogenic lumbosacral radiculopathy. International neurological journal. 2011;5(43):40-46. (In Russ.).
Barinov AN, Makhinov KA, Komarova OA. Preliminary results of Russian open-label multicenter study MINERVA (Milgamma for neurological disorders and pain syndromes). RMJ. 2016;24:1650-1656. (In Russ.).