The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kolomeets N.S.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Disturbance of oligodendrocyte differentiation in schizophrenia in relation to main hypothesis of the disease

Authors:

Kolomeets N.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8): 108‑117

DOI: 10.17116/jnevro201711781108-117

Read: 2267 times

Download PDF (RU)
Contact the author
Table of contents

DISTURBANCE OF OLIGODENDROCYTE DIFFERENTIATION IN SCHIZOPHRENIA IN RELATION TO MAIN HYPOTHESIS OF THE DISEASE
DISTURBANCE OF OLIGODENDROCYTE DIFFERENTIATION IN SCHIZOPHRENIA IN RELATION TO MAIN HYPOTHESIS OF THE DISEASE

To cite this article:

Kolomeets NS. Disturbance of oligodendrocyte differentiation in schizophrenia in relation to main hypothesis of the disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8):108‑117. (In Russ.)
https://doi.org/10.17116/jnevro201711781108-117

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
PANSS six-factor model. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):28-34
Clinical and immu­nological rela­tionships in patients with early schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):35-42
Clinical and psychopathological features of treatment-resistant schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):43-50
Cyto­kine status of patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):5-12
A comprehensive study of Alzheimer’s disease biomarkers in plasma and cere­brospinal fluid. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):43-53
Prospects for treating Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):54-60
Analysis of cognitive status in patients with different noso­logies and clinical variants of very late mani­festing schi­zophreniform psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):88-93
Modern concepts of sleep disturbances asso­ciated with mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):7-12
Asso­ciation of cortisol levels with psychopathological features of depression and therapeutic response in female patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):45-54
The role of mono­cytes in the immu­nopathogenesis of multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):23-27
Abstract:

Increasing evidence coming from neuroimaging, molecular genetic and post-mortem studies have implicated oligodendrocyte abnormalities and compromised myelin integrity in schizophrenia. Activity-dependent myelination in adult brain is considered to be an important mechanism of neural circuit’s plasticity due to the presence of a large population of oligodendrocyte progenitor cells (OPC) in the adult CNS. Growing evidence for impairment of oligodendrocyte differentiation has been reported in the brain of schizophrenia subjects. OPC are very vulnerable inflammation, oxidative stress, and elevated glutamate levels leading to excitotoxicity. The mechanisms of prolonged suppression of oligodendrocyte differentiation caused by prenatal maternal infection or preterm birth are discussed in view of increased risk of schizophrenia, neurodevelopmental and inflammation hypotheses of the disease. The data that some neuroleptics stimulate OPC differentiation and ameliorate myelin alterations support the notion that impairment in the differentiation of OPCs contributes to oligodendrocyte abnormalities and to the pathophysiology of schizophrenia.

Keywords:

schizophrenia
myelination
oligodendrocyte differentiation
neuronal disconnection
neuroinflamation
brain development

Authors:

Kolomeets N.S.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Close metadata

References:

  1. Coyle JT, Balu DT, Puhl MD, Konopaske GT. A perspective on the history of the concept of disconnectivity in schizophrenia. Harv Rev Psychiatry. 2016;24(2):80-86. https://doi.org/10.1097/HRP.0000000000000102
  2. Seidl AH. Regulation of conduction time along axons. Neuroscience. 2014;276:126-134. https://doi.org/10.1016/j.neuroscience.2013.06.047
  3. Fields RD. Myelination: an overlooked mechanism of synaptic plasticity? Neuroscientist. 2005;11(6):528-531. https://doi.org/10.1177/1073858405282304
  4. Sugihara I, Lang EJ, Llinas R. Uniform olivocerebellar conduction time underlies Purkinje cell complex spike synchronicity in the rat cerebellum. J Physiol (Lond). 1993;470:243-271.
  5. Merzenich MM, Jenkins WM, Johnston P, Schreiner C, Miller SL, Tallal P. Temporal processing deficits of language-learning impaired children ameliorated by training. Science. 1996;271:77-81.
  6. Pajevic S, Basser P, Fields RD. Role of myelin plasticity in oscillations and synchrony of neuronal activity. Neuroscience. 2014;276:135-147. https://doi.org/10.1016/j.neuroscience. 2013. 11.007
  7. Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK. Cognitive functions correlate with white matter architecture in normal pediatric population: a diffusion tensor MRI study. Hum Brain Mapp. 2005;26:139-147. https://doi.org/10.1002/hbm.20149
  8. Fields RD. White matter in learning, cognition and psychiatric disorders. Trends Neurosci. 2008;31(7):361-370. https://doi.org/10.1016/j.tins. 2008.04.001
  9. Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AMM, Šestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC. Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci USA. 2012;109(41):16480-16485. https://doi.org/10.1073/pnas.1117943109
  10. Sampaio-Baptista C, Khrapitchev AA, Foxley S, Schlagheck T, Scholz J, Jbabdi S, DeLuca GC, Miller KL, Taylor A, Thomas N, Kleim J, Sibson NR, Bannerman D, Johansen-Berg H. Motor skill learning induces changes in white matter microstructure and myelination. J Neurosci. 2013;33(50):19499-19503. https://doi.org/0.1523/JNEUROSCI.3048-13.2013
  11. López-Barroso D, Catani M, Ripollés P, Dell’Acqua F, Rodríguez-Fornells A, de Diego-Balaguer R. Word learning is mediated by the left arcuate fasciculus. Proc Natl Acad Sci USA. 2013;110(32):13168-13173. https://doi.org/10.1073/pnas.1301696110
  12. Samartzis L, Dima D, Fusar-Poli P, Kyriakopoulos M. White matter alterations in early stages of schizophrenia: a systematic review of diffusion tensor imaging studies. J Neuroimaging. 2014;24(2):101-110. https://doi.org/10.1111/j.1552-6569.2012.00779.x
  13. Ellison-Wright I, Nathan PJ, Bullmore ET, Zaman R, Dudas RB, Agius M, Fernandez-Egea E, Müller U, Dodds CM, Forde NJ, Scanlon C, Leemans A, McDonald C, Cannon DM. Distribution of tract deficits in schizophrenia. BMC Psychiatry. 2014;14:99. https://doi.org/10.1186/1471-244X-14-99
  14. Whitford TJ, Kubicki M, Schneiderman JS, O’Donnell LJ, King R, Alvarado JL, Khan U, Markant D, Nestor PJ, Niznikiewicz M, McCarley RW, Westin C-F, Shenton M. Corpus callosum abnormalities and their association with psychotic symptoms in patients with schizophrenia. Biol Psychiatry. 2010;68(1):70-77. https://doi.org/10.1016/j.biopsych.2010.03.025
  15. Szeszko P, Robinson D, Ashtari M, Vogel J, Betensky J, Sevy S, Ardekani BA, Lencz T, Malhotra AK, McCormack J, Miller R, Lim KO, Gunduz-Bruce H, Kane JM, Bilder RM. Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology. 2008;33:976-984. https://doi.org/10.1038/sj.npp.1301480
  16. Wolkin A, Choi S, Szilagyi S, Sanfilipo M, Rotrosen J, Lim K. Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study. Am J Psychiatry. 2003;160:572-574. https://doi.org/10.1176/appi.ajp.160.3.572
  17. Kubicki M, Niznikiewicz M, Connor E, Ungar L, Nestor P, Bouix S, Dreusicke M, Kikinis R, McCarley R, Shenton M. Relationship between white matter integrity, attention, and memory in schizophrenia: a diffusion tensor imaging study. Brain Imaging Behav. 2009;3(2):191-201. https://doi.org/10.1007/s11682-009-9061-8
  18. Nazeri A, Chakravarty M, Felsky D, Lobaugh NJ, Rajji TK, Mulsant BH, Voineskos AN. Alterations of superficial white matter in schizophrenia and relationship to cognitive performance. Neuropsychopharmacol. 2013;38(10):1954-1962. https://doi.org/10.1038/npp.2013.93
  19. Karbasforoushan H, Duffy B, Blackford JU, Woodward ND. Processing speed impairment in schizophrenia is mediated by white matter integrity. Psychol Med. 2015;45(1):109-120. https://doi.org/10.1017/S0033291714001111
  20. Young KM, Psachoulia K, Tripathi RB, Dunn S-J, Cossell L, Attwell D, Tohyama K, Richardson WD. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron. 2013;77(5):873-885. https://doi.org/10.1016/j.neuron.2013.01.006
  21. Bradl M, Lassmann H. Oligodendrocytes: biology and pathology. Acta Neuropathol. 2010;119(1):37-53. https://doi.org/10.1007/s00401-009-0601-5
  22. Czopka T, Ffrench-Constant C, Lyons DA. Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Dev Cell. 2013;25(6):599-609. https://doi.org/10.1016/ j.devcel.2013.05.013
  23. Watkins TA, Emery B, Mulinyawe S, Barres BA. Distinct stages of myelination regulated by g-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron. 2008;60:555-569. https://doi.org/10.1016/j.neuron.2008.09.011
  24. de Castro F, Bribián A, Ortega MC. Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology. Cell Mol Life Sci. 2013;70:4355-4368. https://doi.org/10.1007/s00018-013-1365-6
  25. Polito A, Reynolds R. NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system. Anat. 2005;207(6):707-716. https://doi.org/10.1111/ j.1469-7580.2005.00454.x
  26. Chang A, Nishiyama A, Peterson J, Prineas J, Trapp BD. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci. 2000;20:6404-6412.
  27. Dawson MR, Polito A, Levine JM, Reynolds R. NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci. 2003;24:476-488. https://doi.org/10.1016/S1044-7431(03)00210-0
  28. Zhu X, Hill RA, Dietrich D, Komitova M, Suzuki R, Nishiyama A. Age-dependent fate and lineage restriction of single NG2 cells. Development. 2011;138(4):745-753. https://doi.org/10.1242/ dev.047951
  29. Gibson EM, Purger D, Mount CW, Goldstein AK, Lin GL, Wood LS, Inema I, Miller SE, Bieri G , Zuchero JB, Barres BA, Woo PJ, Vogel H, Monje M. Neronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science. 2014;344(6183):1252304. https://doi.org/10.1126/science.1252304
  30. Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O’Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. 2014;34:11929-11947. https://doi.org/10.1523/ JNEUROSCI. 1860-14.2014
  31. Xiao L, Ohayon D, McKenzie IA, Sinclair-Wilson A, Wright JL, Fudge AD, Emery B, Li H, Richardson WD. Rapid production of new oligodendrocytes is required in the earliest stages of motor skill learning. Nat Neurosci. 2016;19(9):1210-1217. https://doi.org/10.1038/nn.4351
  32. Xu T, Yu X, Perlik AJ, Tobin WF, Zweig JA, Tennant K, Jones T, Zuo Y. Rapid formation and selective stabilization of synapses for enduring motor memories. Nature. 2009;462:915-919. https://doi.org/10.1038/nature08389
  33. Hornig J, Fröb F, Vogl R M, Hermans-Borgmeyer I, Tamm ER, 3 Wegner M. The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet. 2013;9(10):1003907. https://doi.org/10.1371/ journal. pgen.1003907
  34. Vikhreva OV, Rakhmanova VI, Orlovskaya DD, Uranova NA. Ultrastructural alterations of oligodendrocytes in prefrontal white matter in schizophrenia: A post-mortem morphometric study. Schizophr Res. 2016;177(1-3):28-36. https://doi.org/10.1016/j.schres.2016.04.023
  35. Kolomeets NS, Uranova NA. Pathology of oligodendroglia and myelinated fibers of the hippocampus in schizophrenia (an ultrastructu-ral and morphometric study). Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2008;108(8):52-60. (in Russ.).
  36. Vostrikov VM, Kolomeets NS, Uranova NA. Reduced oligodendroglial density in the inferior parietal lobule and lack of insight in schizophrenia. Eur J Psychiat. 2013;27(2):111-121. https://doi.org/10.4321/S0213-61632013000200004
  37. Hof PR, Haroutunian V, Friedrich VL, Byne W, Buitron C, Perl DP, Davis KL. Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol Psychiatry. 2003;53:1075-1085. https://doi.org/10.1016/S0006-3223(03)00237-3
  38. Falkai P, Steiner J, Malchow B, Shariati J, Knaus A, Bernstein H-G, Schneider-Axmann T, Kraus T, Hasan A, Bogerts B, Schmitt A. Oligodendrocyte and interneuron density in hippocampal subfields in schizophrenia and association of oligodendrocyte number with cognitive deficits. Front Cell Neurosci. 2016;10:78. https://doi.org/10.3389/fncel.2016.00078
  39. Dracheva S, Davis KL, Chin B, Woo DA, Schmeidler J, Haroutunian V. Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in schizophrenia. Neurobiol Dis. 2006;21(3):531-540. https://doi.org/10.1016/ j.nbd.2005.08.012
  40. Dugas JC, Tai YC, Speed TP, Ngai J, Barres BA. Functional genomic analysis of oligodendrocyte differentiation. J Neurosci. 2006;26:10967-10983. https://doi.org/10.1523/ JNEUROSCI.2572-06.2006
  41. Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK. The DISC locus in psychiatric illness. Mol Psychiatry. 2008;13(1):36-64. https://doi.org/10.1038/sj.mp.4002106
  42. Hattori T, Shimizu S, Koyama Y, Emoto H, Matsumoto Y, Kumamoto N, Yamada K, Takamura H, Matsuzaki S, Katayama T, Tohyama M, Ito A. DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes. PLoS One. 2014;9(2):88506. https://doi.org/10.1371/journal.pone.0088506
  43. Katsel P, Tan W, Abazyan B, Davis KL, Ross C, Pletnikov MV, Haroutunian V. Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. Schizophr Res. 2011;130(1-3):238-249. https://doi.org/10.1016/ j.schres. 2011.04.021
  44. Harrison PJ, Law AJ. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry. 2006;60:132-140. https://doi.org/10.1016/ j.biopsych.2005.11.002
  45. Sprooten E, Sussmann JE, Moorhead TW, Whalley HC, Ffrench-Constant C, Blumberg HP, Bastin ME, Hall J, Lawrie SM, McIntosh AM. Association of white matter integrity with genetic variation in an exonic DISC1 SNP. Mol Psychiatry. 2011;16(7):685, 688-689. https://doi.org/10.1038/mp.2011.15
  46. Konrad A, Vucurevic G, Musso F, Stoeter P, Dahmen N, Winterer G. ErbB4 genotype predicts left frontotemporal structural connectivity in human brain. Neuropsychopharmacol. 2009;34:641-650. https://doi.org/10.1038/npp.2008.112
  47. Georgieva L, Moskvina V, Peirce T, Norton N, Bray NJ, Jones L, Holmans P, Macgregor S, Zammit S, Wilkinson J, Williams H, Nikolov I, Williams N, Ivanov D, Davis KL, Haroutunian V, Buxbaum JD, Craddock N, Kirov G, Owen MJ, O’Donovan MC. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc Natl Acad Sci USA. 2006;103(33):12469-12474. https://doi.org/10.1073/pnas.0603029103
  48. Ross SE, Greenberg ME, Stiles CD. Basic helix-loop-helix factors in cortical development. Neuron. 2003;39:13-25. https://doi.org/10.1016/S0896-6273(03)00365-9
  49. Aberg K, Saetre P, Jareborg N, Jazin E. Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. Proc Natl Acad Sci USA. 2006;103(19):7482-7487. https://doi.org/10.1073/pnas.0601213103
  50. Larocque D, Richard S. QUAKING KH domain proteins as regulators of glial cell fate and myelination. RNA Biol. 2005;2(2):37-40. https://doi.org/10.4161/rna.2.2.1603
  51. Katsel P, Davis KL, Li C, Tan W, Greenstein E, Kleiner Hoffman LB, Haroutunian V. Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes. Neuro-psychopharmacol. 2008;33(12):2993-3009. https://doi.org/10.1038/ npp.2008.19
  52. Mauney SA, Pietersen CY, Sonntag KC, Woo TU. Differentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia. Schizophr Res. 2015;169:374-380. https://doi.org/10.1016/j.schres.2015.10.042
  53. Bernstein HG, Jauch E, Dobrowolny H, Mawrin C, Steiner J, Bogerts B. Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2016;266(6):495-504. https://doi.org/10.1007/s00406-015-0640-y
  54. Vázquez-Bourgon J, Mata I, Roiz-Santiáñez R, Ayesa-Arriola R, Suárez Pinilla P, Tordesillas-Gutiérrez D, Vázquez-Barquero JL, Crespo-Facorro B. Disrupted-in-Schizophrenia 1 gene variant is associated with clinical symptoma-tology in patients with first-episode psychosis. Psychiatry Investig. 2014;11:186-191. https://doi.org/10.4306/pi.2014.11.2.186
  55. Nakata K, Lipska BK, Hyde TM, Ye T, Newburn EN, Morita Y, Vakkalanka R, Barenboim M, Sei Y, Weinberger DR, Kleinman JE. DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc Natl Acad Sci USA. 2009;106(37):15873-15878. https://doi.org/10.1073/pnas.0903413106
  56. Vostrikov VM, Kolomeets NS, Uranova NA. Oligodendrocyte abnormalities in layer 5 in the inferior parietal lobule are associated with lack of insight: a postmortem morphometric study. Eur J Psychiat. 2015;29 (3):215-222.
  57. Kolomeets NS, Uranova NA. Abnormalities of oligodendrocyte clusters in the inferior parietal cortex in schizophrenia: effect of age at onset. Psychiatry. 2015;3(67):52-57. (In Russ.).
  58. McTigue DM, Tripathi RB. The life, death, and replacement of oligodendrocytes in the adult CNS. J Neurochem. 2008;107:1-19. https://doi.org/10.1111/j.1471-4159.2008.05570.x
  59. Connor RR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia. 1996;17:83-93. https://doi.org/10.1002/(SICI)1098-1136(199606)17:2<83::AID-GLIA1> 3.0.CO;2-7.
  60. Thorburne SK, Juurlink BH. Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress. J Neurochem. 1996;67:1014-1022.
  61. Tanaka H, Grooms SY, Bennett MV, Zukin RS. The AMPAR subunit GluR2: still front and center-stage. Brain Res. 2000;886:190-207.
  62. Salter MG, Fern R. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury. Nature. 2005;438:1167-1171. https://doi.org/10.1038/nature04301
  63. Alberdi E, Sánchez-Gómez MV, Torre I, Domercq M, Pérez-Samarín A, Pérez-Cerdá F, Matute C. Activation of kainate receptors sensitizes oligodendrocytes to complement attack. J Neurosci. 2006;26:3220-3228. https://doi.org/10.1523/JNEUROSCI.3780-05.2006
  64. Bergsteindottir K, Brennan A, Jessen KR, Mirsky R. In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules. Proc Natl Acad Sci USA. 1992;89(19):9054-9058.
  65. Bsibsi M, Nomden A, van Noort JM, Baron W.Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane forma-tion. J Neurosci Res. 2012;90(2):388-398. https://doi.org/10.1002/jnr.22767
  66. Cannella B, Raine CS. Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation. Ann Neurol. 2004;55(1):46-57. https://doi.org/10.1002/ana.10764
  67. Patel JR, McCandless EE, Dorsey D, Klein RS. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc Natl Acad Sci USA. 2010;107(24):11062-11067. https://doi.org/10.1073/pnas.1006301107
  68. Itoh T, Horiuchi M, Itoh A. Interferon-triggered transcriptional cascades in the oligodendroglial lineage: a comparison of induction of MHC class II antigen between oligodendroglial progenitor cells and mature oligodendrocytes. J Neuroimmunol. 2009;212(1-2):53-64. https://doi.org/10.1016/j.jneuroim.2009.04.021
  69. Müller N, Myint AM, Schwarz MJ. Inflammation in schizophrenia. Adv Protein Chem Struct Biol. 2012;88:49-68. https://doi.org/10.101/B978-0-12-398314-5.00003-9
  70. Najjar S, Pearlman DM. Neuroinflammation and white matter pathology in schizophrenia: systematic review. Schizophr Res. 2015;161(1):102-112. https://doi.org/10.1016/ j.schres. 2014.04.041
  71. Trépanier MO, Hopperton KE, Mizrahi R, Mechawar N, Bazinet RP. Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review. Mol Psychiatry. 2016;21(8):1009-1026. https://doi.org/10.1038/mp.2016.90
  72. Meisenzahl EM, Rujescu D, Kirner A, Giegling I, Kathmann N, Leinsinger G, Maag K, Hegerl U, Hahn K, Möller HJ. Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia. Am J Psychiatry. 2001;158(8):1316-1319. https://doi.org/10.1176/appi.ajp.158.8.1316
  73. Prasad KM, Upton CH, Nimgaonkar VL, Keshavan MS. Differential susceptibility of white matter tracts to inflammatory mediators in schizophrenia: an integrated DTI study. Schizophr Res. 2015;161(1):119-125. https://doi.org/10.1016/j.schres.2014.09.043
  74. Fillman SG, Cloonan N, Miller LC, Weickert CS. Markers of inflammation in the prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013;18(2):133. https://doi.org/10.1038/mp.2012.199
  75. Brown AS, Derkits EJ. Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry. 2010;167(3):261-280. https://doi.org/10.1176/appi.ajp. 2009.09030361
  76. Khandaker GM, Zimbron J, Lewis G, Jones PB. Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychol Med. 2013;43(2):239-257. https://doi.org/10.1017/S0033291712000736
  77. Elovitz MA,Wang Z, Chien EK, Rychlik DF, Phillippe M. A new model for inflammation-induced preterm birth. The role of platelet-activating factor and toll-like receptor-4. Am J Pathol. 2003;163(5):2103-2111. https://doi.org/10.1016/S0002-9440(10)63567-5
  78. Larsen JK, Bendsen BB, Foldager L, Munk-Jorgensen P. Prematurity and low birth weight as risk factors for the development of affective disorder,especially depression and schizophrenia: a register study. Acta Neuropsychiatrica. 2010;22:284-291. https://doi.org/10.1111/j.1601-5215.2010. 00498.x
  79. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipila P. Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: a 28-year follow-up of the 1966 north Finland general population birth cohort. Am J Psychiatry. 1998;155(3):355-364. https://doi.org/10.1176/ajp.155.3.355
  80. Volpe JJ. Neurology of the Newborn. 5 Edition. Elsevier; Philadelphia: 2008.
  81. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA. The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci. 2011;29(4):423-440. https://doi.org/10.1016/j.ijdevneu.2011.02.012
  82. Khwaja O, Volpe JJ. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008;93(2):F153-161. https://doi.org/10.1136/adc.2006.108837
  83. Buser JR, Maire J, Riddle A, Gong X, Nguyen T, Nelson K, Luo NL, Ren J, Struve J, Sherman LS, Miller SP, Chau V, Hendson G, Ballabh P, Grafe MR, Back SA. Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants. Ann Neurol. 2012;71(1):93-109. https://doi.org/10.1002/ana.22627
  84. Soul JS, Hammer PE, Tsuji M, Saul P, Bassan H, Limperopoulos C, Moore M, Walter G, Akins P, Ringer SA, Volpe JJ, Trachtenberg F, du Plessis AJ. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res. 2007;61(4):467-473. https://doi.org/10.1203/pdr.0b013e31803237f6
  85. Back SA, Rosenberg PA. Pathophysiology of glia in perinatal white matter injury. Glia. 2014;62(11):1790-1815. https://doi.org/10.1002/glia.22658
  86. Verney C, Monier A, Fallet-Bianco C, Gressens P. Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants. J Anat. 2010;217(4):436-448. https://doi.org/10.1111/j.1469-7580.2010.01245.x
  87. Luppi P. How immune mechanisms are affected by pregnancy. Vaccine. 2003;21(24):3352-3357. https://doi.org/10.1016/S0264-410X(03)00331-1
  88. Falahati S, Breu M, Waickman AT, Phillips AW, Arauz EJ, Snyder S, Porambo M, Goeral K, Comi AM, Wilson MA, Johnston MV, Fatemi A. Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. Dev Neurosci. 2013;35(2-3):182-196. https://doi.org/10.1159/000346682
  89. Haynes RL, Folkerth RD, Trachtenberg FL, Volpe JJ, Kinney HC. Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia. Acta Neuropathol. 2009;118:391-399. https://doi.org/10.1007/s00401-009-0540-1
  90. Folkerth RD, Haynes RL, Borenstein NS, Belliveau RA, Trachtenberg F, Rosenberg PA, Volpe JJ, Kinney HC. Developmental lag in superoxide dismutases relative to other antioxidant enzymes in premyelinated human telencephalic white matter. J Neuropathol Exp Neurol. 2004;63:990-999. https://doi.org/10.1093/jnen/63.9.990
  91. Back SA, Luo NL, Mallinson RA, O’Malley JP, Wallen LD, Frei B, Morrow JD, Petito CK, Roberts CT, Murdoch GH, Montine TJ. Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes. Ann Neurol. 2005;58:108-120. https://doi.org/10.1002/ ana.20530
  92. Holopainen IE, Laurén HB. Glutamate signaling in the pathophysiology and therapy of prenatal insults. Pharmacol Biochem Behav. 2012;100(4):825-834. https://doi.org/10.1016/j.pbb.2011. 03.016
  93. Itoh T, Beesley J, Itoh A, Cohen AS, Kavanaugh B, Coulter DA, Grinspan JB, Pleasure D. AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes. J Neurochem. 2002;81(2):390-402. https://doi.org/10.1046/j.1471-4159.2002.00866.x
  94. Matute C, Domercq M, Sánchez-Gómez MV. Glutamate-mediated glial injury: mechanisms and clinical importance. Glia. 2006;53:212-224. https://doi.org/10.1002/glia.20275
  95. Riddle A, Luo NL, Manese M, Beardsley DJ, Green L, Rorvik DA, Kelly KA, Barlow CH, Kelly JJ, Hohimer AR, Back SA. Spatial heterogeneity in oligodendrocyte lineage maturation and not cerebral blood flow predicts fetal ovine periventricular white matter injury. J Neurosci. 2006;26(11):3045-3055. https://doi.org/10.1523/JNEUROSCI.5200-05.2006
  96. Segovia KN, McClure M, Moravec M, Luo NL, Wan Y, Gong X, Riddle A, Craig A, Struve J, Sherman LS, Back SA. Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury. Ann Neurol. 2008;63:520-530. https://doi.org/10.1002/ana.21359
  97. Skranes J, Vangberg TR, Kulseng S, Indredavik MS, Evensen KA, Martinussen M, Dale AM, Haraldseth O, Brubakk AM. Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight. Brain. 2007;130(3):654-666. https://doi.org/10.1093/brain/awm001
  98. Kontis D, Catani M, Cuddy M, Walshe M, Nosarti C, Jones D, Wyatt J, Rifkin L, Murray R, Allin M. Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm. Neuroreport. 2009;20(4): 424-428. https://doi.org/10.1097/WNR.0b013e328325a8f9
  99. Taylor HG, Minich NM, Klein N, Hack M. Longitudinal outcomes of very low birth weight: neuropsychological findings. J Int Neuropsychol Soc. 2004;10(2):149-163. https://doi.org/10.1017/S1355617704102038
  100. Saigal S. Functional outcomes of very premature infants into adulthood. Semin Fetal Neonatal Med. 2014;19(2):125-130. https://doi.org/10.1016/j.siny.2013.11.001
  101. Ellman LM, Deicken RF, Vinogradov S, Kremen WS, Poole JH, Kern DM, Tsai WY, Schaefer CA, Brown AS. Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8. Schizophrenia Research. 2010;121:46-54. https://doi.org/10.1016/j.schres.2010.05.014
  102. Nosarti C, Reichenberg A, Murray RM, Cnattingius S, Lambe MP, Yin L, MacCabe J, Rifkin L, Hultman CM. Preterm birth and psychiatric disorders in young adult life. Arch Gen Psychiatry. 2012;69(6):1-8. https://doi.org/10.1001/archgenpsychiatry.2011.1374
  103. Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci. 2008;9(12):947-957. https://doi.org/10.1038/nrn2513
  104. Perry VH, Cunningham C, Holmes C. Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol. 2007;7(2):161-167. https://doi.org/10.1038/nri2015
  105. Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci. 2005;25(40): 9275-9284. https://doi.org/10.1523/ JNEUROSCI.2614-05.2005
  106. Norden DM, Godbout JP. Review: microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol. 2013;39(1):19-34. https://doi.org/10.1111/j.1365-2990.2012.01306.x
  107. Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation. 2008;15(4-6):323-330. https://doi.org/10.1159/000156474
  108. Frank MG, Baratta MV, Sprunger DB, Watkins LR, Maier SF. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun. 2007;21(1):47-59. https://doi.org/10.1016/j.bbi.2006.03.005
  109. Giovanoli S, Engler H, Engler A, Richetto J, Feldon J, Riva MA, Schedlowski M, Meyer U. Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia. Transl Psychiatry. 2016;6:772. https://doi.org/10.1038/tp.2016.38
  110. Fang F, Zhang H, Zhang Y, Xu H, Huang Q, Adilijiang A, Wang J, Zhang Z, Zhang D, Tan Q, He J, Kong L, Liu Y, Li XM. Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2. Life Sci. 2013;93(12-14):429-434. https://doi.org/10.1016/j.lfs.2013.08.004
  111. Gregg JR, Herring NR, Naydenov AV, Hanlin RP, Konradi C. Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats. Schizophr Res. 2009;113:277-287. https://doi.org/10.1016/j.schres.2009.05.023
  112. Zhang H, Zhang Y, Xu H, Wang L, Adilijiang A, Wang J, Hartle K, Zhang Z, Zhang D, Tan Q, Kong J, Huang Q, Li XM. Olanzapine ameliorates neuropathological changes and increases IGF-1 expression in frontal cortex of C57BL/6 mice exposed to cuprizone. Psychiatry Res. 2014;216(3):438-445. https://doi.org/10.1016/j.psychres.2014.02.019
  113. Xu H, Yang HJ, McConomy B, Browning R, Li XM. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front Behav Neurosci. 2010;4:8. https://doi.org/10.3389/fnbeh.2010.00008
  114. Wang HN, Liu GH, Zhang RG, Xue F, Wu D, Chen YC, Peng Y, Peng ZW, Tan QR. Quetiapine ameliorates schizophrenia-like behaviors and protects myelin integrity in cuprizone intoxicated mice: the involvement of notch signaling pathway. Int J Neuropsychopharmacol. 2015;19(2):88. https://doi.org/10.1093/ijnp/pyv088
  115. Kondo MA, Tajinda K, Colantuoni C, Hiyama H, Seshadri S, Huang B, Pou S, Furukori K, Hookway C, Jaaro-Peled H, Kano SI, Matsuoka N, Harada K, Ni K, Pevsner J, Sawa A. Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control. Transl Psychiatry. 2013;3:243. https://doi.org/10.1038/tp.2013.19
  116. Garver DL, Holcomb JA, Christensen JD. Compromised myelin integrity during psychosis with repair during remission in drug-responding schizophrenia. Int J Neuropsychopharmacol. 2008;11:49-61. https://doi.org/10.1017/S1461145707007730
  117. Mei F, Guo S, He Y, Wang L, Wang H, Niu J, Kong J, Li X, Wu Y, Xiao L. Quetiapine, an atypical antipsychotic, is protective against autoimmune-mediated demyelination by inhibiting effector T cell proliferation. PLoS One. 2012;7(8):42746. https://doi.org/10.1371/journal.pone.0042746
  118. O’Sullivan D, Green L, Stone S, Zareie P, Kharkrang M, Fong D, Connor B, La Flamme AC. Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis. PLoS One. 2014;9(8):104430. https://doi.org/10.1371/ journal.pone.0104430
  119. Meyer U, Schwarz MJ, Muller N. Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond. Pharmacol Ther. 2011;132:96-110. https://doi.org/10.1016/j.pharmthera.2011.06.003
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.