Modeling of hemodynamic changes in the aneurysm of the middle cerebral artery depending on the pathology of the parent artery

Krylov V.V.; Gavrilov A.V.; Yatchenko A.M.; Grigorieva Е.V.; Godkov I.M.; Arkhipov I.V.; Boldyreva E.V.; Archakov A.

doi:https://doi.org/10.17116/jnevro20161165157-64

Krylov V.V.

FGBU MRNTs Minzdrava Rossii, Obninsk

Gavrilov A.V.

Lomonosov Moscow State University, Moscow, Russia

Yatchenko A.M.

Lomonosov Moscow State University, Moscow, Russia

Grigorieva Е.V.

Federal State Budgetary Institution «Federal Center of Traumatology, Orthopedics and endoprosthesis replacement» of Ministry of Health of the Russian Federation, Cheboksary, Russia

Godkov I.M.

Research Institute of emergency medicine named after N.V. Sklifosofskiy, Moscow

Arkhipov I.V.

Lomonosov Moscow State University, Moscow, Russia

Boldyreva E.V.

Blagonravov Institute of Mashine Science, Moscow, Russia

Archakov A.

Sklifosovsky Emergency Medicine Research Institute, Moscow, Russia

Modeling of hemodynamic changes in the aneurysm of the middle cerebral artery depending on the pathology of the parent artery

Authors:

Krylov V.V., Gavrilov A.V., Yatchenko A.M., Grigorieva Е.V., Godkov I.M., Arkhipov I.V., Boldyreva E.V., Archakov A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(5): 57‑64

DOI: 10.17116/jnevro20161165157-64

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To cite this article:

Krylov VV, Gavrilov AV, Yatchenko AM, et al. Modeling of hemodynamic changes in the aneurysm of the middle cerebral artery depending on the pathology of the parent artery. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(5):57‑64. (In Russ.)
https://doi.org/10.17116/jnevro20161165157-64

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To examine the influence of the parent artery pathology on the local hemodynamics on the level of aneurysm. Material and methods. Mathematical modelsof the arteriovenous malformation (AVM) were built on the CT-angiography data of real patients. To simulate the thrombosis, the parent artery and its branches were sequentially turned off in the model 1. In the model 2, the simulation of embolization of AVM was achieved by cutting off the exactly section of the parent artery that was involved in the arteriovenous formation. Results and conclusion. Model 1 showedthat the flow redistribution did not significantly impact on the risk of rupture after the parent artery was turned off and blood pressure was increased in both aneurysms by 3 mm Hg. Model 2, in which the aneurysms were combined with a direct arteriovenous drainage with low peripheral resistance, showed that turning off the parent artery and pathological drainage led to the serious reduction inthe venous drainage flow and it’s increasing in the parent artery by about 60% that significantly increased the risk of rupture.

Keywords:

modeling

hemodynamics

aneurysm

arteriovenous malformation

Authors:

Krylov V.V.

FGBU MRNTs Minzdrava Rossii, Obninsk

Gavrilov A.V.

Lomonosov Moscow State University, Moscow, Russia

Yatchenko A.M.

Lomonosov Moscow State University, Moscow, Russia

Grigorieva Е.V.

Federal State Budgetary Institution «Federal Center of Traumatology, Orthopedics and endoprosthesis replacement» of Ministry of Health of the Russian Federation, Cheboksary, Russia

Godkov I.M.

Research Institute of emergency medicine named after N.V. Sklifosofskiy, Moscow

Arkhipov I.V.

Lomonosov Moscow State University, Moscow, Russia

Boldyreva E.V.

Blagonravov Institute of Mashine Science, Moscow, Russia

Archakov A.

Sklifosovsky Emergency Medicine Research Institute, Moscow, Russia

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