Objective. To study an effect of sanatorium-climate therapy in patients with chronic obstructive pulmonary disease (COPD) with comorbid depressive disorders. Material and methods. The scale of depression CES-D and the Spielberger—Khanin scale of anxiety were administered to 146 patients with COPD, treated in the sanatorium in the south coast of Crimea. Results and conclusion. Depressive disorders were identified in 72.6% of patients, including moderate and severe disorders (41.8%). Anxiety disorders were found in 67.1% of patients. The severity of anxiety-depressive disorders was correlated with the COPD degree. It was shown that the sanatorium-resort treatment has a beneficial effect on mental status of the patients. The best results were demonstrated for mild degree of COPD.