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Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Karneev A.N.

Chekanov A.V.

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

The individual and combined antioxidant effects of citicoline and ethylmethylhydroxypyridini succinas

Authors:

Solov'eva É.Iu., Karneev A.N., Chekanov A.V., Baranova O.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11): 78‑85

DOI: 10.17116/jnevro201611611178-85

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THE INDIVIDUAL AND COMBINED ANTIOXIDANT EFFECTS OF CITICOLINE AND ETHYLMETHYLHYDROXYPYRIDINI SUCCINAS
THE INDIVIDUAL AND COMBINED ANTIOXIDANT EFFECTS OF CITICOLINE AND ETHYLMETHYLHYDROXYPYRIDINI SUCCINAS

To cite this article:

Solov'eva ÉIu, Karneev AN, Chekanov AV, Baranova OA. The individual and combined antioxidant effects of citicoline and ethylmethylhydroxypyridini succinas. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11):78‑85. (In Russ.)
https://doi.org/10.17116/jnevro201611611178-85

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Objective. To study the antioxidant status of patients with chronic cerebral ischemia (CCI) during the individual treatment with 2-ethyl-6-methyl-3-hydroxypyridine-succinate (neurox) and in the combination with citicoline (neipilept). Material and methods. A study included 40 patients, 18 men and 22 women, aged from 54 to 72 years, with CCI, stage 2, at the decompensation stage complicated with the hypertensive crisis and/or arrhythmia. Results and Conclusion. A significant increase in the serum superoxide dismutase activity after the complex therapy with neurox and neipilept was demonstrated compared to patients treated with neurox. A study of reduced sulfur-hydroxy groups in patients treated with 2-ethyl-6-methyl-3-hydroxypyridine-succinate and patients treated with the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline, revealed a significant increase in the number of reduced SH- groups after the treatment with neurox compared to the combined use of neurox and neipilept.

Keywords:

brain ischemia
stroke
phospholipids
phosphatidylcholine
free radicals
citicoline
2-ethyl-6-methyl-3-hydroxypyridine-succinate

Authors:

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Karneev A.N.

Chekanov A.V.

Baranova O.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova;
Nauchno-issledovatel'skiĭ institut fiziko-khimicheskoĭ meditsiny FMBA Rossii, laboratoriia fiziko-khimicheskikh metodov issledovaniia i analiza, Moskva

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