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Giliarov M.Yu.

I.M. Sechenov First Moscow State Medical University under the Ministry of Health of the Russia, 119991, Moscow, Russia;
N.I. Pirogov Moscow Municipal Hospital №1, Moscow, 119049, Russia

Belikova L.P.

Pirogov City Clinical Hospital, Moscow, Russia

Shchukin I.A.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Fidler M.S.

Pirogov City Clinical Hospital, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Avakian G.G.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Shustrova G.E.

Pirogov City Clinical Hospital, Moscow, Russia

Martynov M.Yu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Svet A.V.

GOU VPO Pervyĭ MGMU im. I.M. Sechenova Minzdrava Rossii

Neurological disorders in eosinophilic granulomatosis with polyangiitis (Churg—Strauss syndrome)

Authors:

Giliarov M.Yu., Belikova L.P., Shchukin I.A., Fidler M.S., Avakian G.G., Shustrova G.E., Martynov M.Yu., Svet A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10): 93‑102

DOI: 10.17116/jnevro201611610193-102

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Table of contents

NEUROLOGICAL DISORDERS IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (CHURG—STRAUSS SYNDROME)
NEUROLOGICAL DISORDERS IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (CHURG—STRAUSS SYNDROME)

To cite this article:

Giliarov MYu, Belikova LP, Shchukin IA, et al. Neurological disorders in eosinophilic granulomatosis with polyangiitis (Churg—Strauss syndrome). S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10):93‑102. (In Russ.)
https://doi.org/10.17116/jnevro201611610193-102

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Eosinophilic granulomatosis with polyangiitis — EGPA (Churg—Strauss syndrome) is a rare autoimmune disorder. The pathogenesis of the disease includes production of anti-neutrophil cytoplasmic antibodies directed against myeloperoxidase with the development of small-vessel necrotizing vasculitis and eosinophilic infiltration of organs. The involvement of peripheral and central nervous system is observed in more than 3/4 of cases. The authors describe three patients with EGPA. In a 53-year-old male patient, EGPA manifested with multiple neuropathies, which regressed after treatment with corticosteroids and cytostatics. In a 34-year-old woman, cerebral sinus thrombosis and cerebral infarction developed in the non-active period of long-term EGPA. The patient was treated with anticoagulants. A 77-year-old woman with a newly diagnosed EGPA, confirmed by bone marrow examination for eosinophilia, developed ischemic stroke and polyneuropathy. The causes and mechanisms of development as well as dynamics and outcomes of neurological disorders, differential diagnosis, treatment and prognosis of eosinophilic granulomatosis with polyangiitis are discussed.

Keywords:

eosinophilic granulomatosis with polyangiitis
Churg—Strauss syndrome
ANCA
eosinophilia
vasculitis
neuropathy
polyneuropathy
stroke
venous sinus thrombosis

Authors:

Giliarov M.Yu.

I.M. Sechenov First Moscow State Medical University under the Ministry of Health of the Russia, 119991, Moscow, Russia;
N.I. Pirogov Moscow Municipal Hospital №1, Moscow, 119049, Russia

Belikova L.P.

Pirogov City Clinical Hospital, Moscow, Russia

Shchukin I.A.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Fidler M.S.

Pirogov City Clinical Hospital, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Avakian G.G.

Department of Neurology and Neurosurgery of the N.I. Pirogov Russian National Research Medical University

Shustrova G.E.

Pirogov City Clinical Hospital, Moscow, Russia

Martynov M.Yu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta

Svet A.V.

GOU VPO Pervyĭ MGMU im. I.M. Sechenova Minzdrava Rossii

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