Objective: To study different methods of treatment of patients with myofascial pain syndrome (MFPS). Material and methods: We evaluated the efficacy of complex treatment in 152 patients with chronic tension-type headache (СЕЕР) and 96 patients with facial MFPS. The treatment included standard methods (reflex therapy of СЕЕР and local injections of a combination of local anesthetics with small doses of steroids in trigger points in patients with facial MFPS. To assess the efficacy of tizanidine, patients were randomized into two comparable groups. The duration of the study was 12 weeks. Results and сonclusion: The combined therapy, including reflex action and tizanidine, speeds recovery from pain and ensures the stability of results.