The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Storozheva Z.I.

Gosudarstvennyĭ nauchnyĭ tsentr sotsialnoĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo, Moskva;
Nauchno-issledovatelskiĭ institut normalnoĭ fiziologii im. P.K. Anokhina RAMN, Moskva

Kirenskaia A.V.

Lazarev I.E.

Novototskiĭ-Vlasov V.Iu.

Samylkin D.V.

Fastovtsov G.A.

Prepulse modification of acoustic startle reaction in patients with schizophrenia and healthy controls

Authors:

Storozheva Z.I., Kirenskaia A.V., Lazarev I.E., Novototskiĭ-Vlasov V.Iu., Samylkin D.V., Fastovtsov G.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(2): 72‑75

Read: 1457 times

Download PDF (RU)
Contact the author
Table of contents

PREPULSE MODIFICATION OF ACOUSTIC STARTLE REACTION IN PATIENTS WITH SCHIZOPHRENIA AND HEALTHY CONTROLS
PREPULSE MODIFICATION OF ACOUSTIC STARTLE REACTION IN PATIENTS WITH SCHIZOPHRENIA AND HEALTHY CONTROLS

To cite this article:

Storozheva ZI, Kirenskaia AV, Lazarev IE, Novototskiĭ-Vlasov VIu, Samylkin DV, Fastovtsov GA. Prepulse modification of acoustic startle reaction in patients with schizophrenia and healthy controls. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(2):72‑75. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Analysis of cognitive status in patients with different noso­logies and clinical variants of very late mani­festing schi­zophreniform psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):88-93
Modern concepts of sleep disturbances asso­ciated with mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):7-12
Asso­ciation of cortisol levels with psychopathological features of depression and therapeutic response in female patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):45-54
Factors supporting chro­nic inflammation in mental illness. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):7-15
Age transformation of leading clinical diagnoses in adolescents and young people with non-suicidal self-harm. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10-2):48-56
Constitutional and morphological bases of suicidal beha­vior in patients with schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):52-56
Search for risk factors for slowed intra-atrial conduction in patients with schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):111-116
Search for neurophysiological markers of schi­zophrenia spectrum diso­rders: ocular microtremor and contrast sensitivity. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):228-236
Transcranial electrostimulation as part of combination therapy for mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(1):37-44
Prognostic value of athe­rogenicity indi­ces in schi­zophrenia patients with meta­bolic syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(3):155-160
Abstract:

Prepulse modification of acoustic startle reaction (ASR) was studied in patients with schizophrenia and healthy controls according to the protocol recommended by the Consortium on the genetics of schizophrenia. Patients displayed the reduced ASR magnitude of prepulse inhibition (PPI) and increased startle latency prepulse facilitation (PPF) at 60 ms lead interval. The ASR amplitude PPF at 2500 ms lead interval was also impaired in patients. Effects of the recent head trauma and psychoactive drug experience on the ASR prepulse modification were different in patients and controls. The high baseline amplitude and short ASR latency in patients were correlated with the excitation level measured with the PANSS (item P4) whereas the PPF reduction was correlated with the high total score on the PANSS positive subscale. These results suggest the possibility of using ASR prepulse modification in clinical neurophysiology.

Keywords:

acoustic startle reaction
prepulse inhibition
prepulse facilitation
attention disorders
schizophrenia

Authors:

Storozheva Z.I.

Gosudarstvennyĭ nauchnyĭ tsentr sotsialnoĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo, Moskva;
Nauchno-issledovatelskiĭ institut normalnoĭ fiziologii im. P.K. Anokhina RAMN, Moskva

Kirenskaia A.V.

Lazarev I.E.

Novototskiĭ-Vlasov V.Iu.

Samylkin D.V.

Fastovtsov G.A.

Close metadata

References:

  1. Mosolov S.N. Shkaly psikhometricheskoi otsenki simptomatiki shizofrenii i kontseptsiya pozitivnykh i negativnykh rasstroistv. M: Novyi tsvet 2001.
  2. Dawson M.E., Schell A.M., Swerdlov N.R. et al. Attention and orienting. Sensory and motivational processes. Hillsdale NJ: Erbaum 1997; 491.
  3. Escobar M., Oberling P., Miller R.R. Associative deficit accounts of disrupted latent inhibition and blocking in schizophrenia. Neurosci Biobehav Rev 2002; 26: 2: 203-216.
  4. Gal G., Barnea Y., Biran L. et al. Enhancement of latent inhibition in patients with chronic schizophrenia. Behav Brain Res 2009; 197: 1: 1-8.
  5. Geyer M.A., Krebs-Thomson K., Braff D.L., Swerdlow N.R. Studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia.Psychopharmacology (Berl) 2001; 156: 117-154.
  6. Gironell A., Rodríguez-Fornells A., Kulisevsky J. et al. Abnormalities of the acoustic startle reflex and reaction time in gilles de la tourette syndrome. Clin Neurophysiol 2000; 111: 8: 1366-1371.
  7. Greenwood T.A., Braff D.L., Light G.A. et al. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch Gen Psychiatry 2007; 64: 11: 1242-1250.
  8. Hasenkamp W., Norrholm S.D., Green A. et al. Differences in startle reflex and prepulse inhibition in European-Americans and African-Americans. Psychophysiology 2008; 45: 5: 876-882.
  9. Hong L.E., Wonodi I., Lewis J., Thaker G.K. Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients. Neuropsychopharmacology 2008; 33: 9: 2167-2174.
  10. Kumari V., Antonova E., Geyer M.A. et al. A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics. Int J Neuropsychopharmacol 2007; 10: 4: 463-477.
  11. Minassian A., Feifel D., Perry W. The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients. Schizophr Res 2007; 89: 1-3: 225-231.
  12. Perry W., Geyer M.A., Braff D.L. Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients. Arch Gen Psychiatry 1999; 56: 277-281.
  13. Swerdlow N.R., Light G.A., Cadenhead K.S. et al. Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function. Arch Gen Psychiatry 2006; 63: 12: 1325-1335.
  14. Swerdlow N.R., Sprock J., Light G.A. et al. Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia. Schizophr Res 2007; 92: 1-3: 237-251.
  15. van Os J., Rutten B.P., Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 2008; 34: 6: 1066-1082.
  16. Vollenweider F.X., Csomor P.A., Knappe B. et al. The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval. Neuropsychopharmacology 2007; 32: 1876-1887.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.