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Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Kalacheva A.G.

Ivanovo State Medical Academy, Ministry of Health of Russia

Kuramshina D.B.

Molecular-biological basics of neuroprotection effects of magnesium

Authors:

Gromova O.A., Torshin I.Iu., Kalacheva A.G., Kuramshina D.B.

More about the authors

Read: 11085 times


To cite this article:

Gromova OA, Torshin IIu, Kalacheva AG, Kuramshina DB. Molecular-biological basics of neuroprotection effects of magnesium. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12):90‑101. (In Russ.)

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References:

  1. Gogoleva I.V. Vliyanie organicheskikh solei litiya, magniya, selena na elementnyi gomeostaz golovnogo mozga na fone eksperimental'noi khronicheskoi okklyuzii obshchikh sonnykh arterii: Avtoref. dis. … kand. med. nauk. M 2009; 25.
  2. Gromova O.A. Magnii i piridoksin. Osnovy znanii. M: ProtoTip 2006; 234.
  3. Gromova O.A., Kalacheva A.G., Satarina T.E. i dr. Vliyanie preparata Magne V6 na parametry stressa i kognitivnuyu funktsiyu pri vysokikh psikhoemotsional'nykh nagruzkakh. Trudnyi patsient 2008; 6: 12: 28-32.
  4. Gusev E.I., Skvortsova V.I. Ishemiya golovnogo mozga. M: Meditsina 2001; 678.
  5. Kalacheva A.G. Element-spetsificheskie indikatory neirotropnykh funktsii magniya: Avtoref. dis. … kand. med. nauk. M 2011; 23.
  6. Orlova S.V. Obespechennost' magniem po dannym otsenki ratsiona pitaniya rossiyan. Vestnik RUDN 2009.
  7. Skoromets A.A., Gromova O.A., Fedotova L.E. Potentsirovanie neiroprotektornoi terapii u bol'nykh s rannimi formami tserebrovaskulyarnoi patologii preparatom Magne V6. Ros pediat zhurn 2005; 1: 30-36.
  8. Slobodin V.B., Tomilova I.K. Patologicheskaya fiziologiya i eksperimental'naya terapiya 2007; 2: 17-19.
  9. Torshin I.Yu., Gromova O.A. Dvadtsat' pyat' mgnovenii molekulyarnoi farmakologii. A-Grif 2011; 560.
  10. Acheson A., Conover J.C., Fandl J.P. et al. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 1995; 374: 6521: 450-453.
  11. Al-Shawi R., Hafner A., Chun S., Raza S. ProNGF, Sortilin, and Age-related Neurodegeneration. Ann N Y Acad Sci 2007; 1119: 208.
  12. Altura B.M., Shah N.C., Jiang X.C. et al. Short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissues. Am J Physiol Heart Circ Physiol 2009; 297: 1: 86-92.
  13. Aslanyan S., Weir C.J., Muir K.W., Lees K.R. Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial. Stroke 2007; 38: 4: 1269-1273.
  14. Bekinschtein P., Cammarota M., Katche C. et al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci USA 2008; 105: 7: 2711-2716.
  15. Bhat M.A. Magnesium sulfate in severe perinatal asphyxia: a randomized, placebo-controlled trial. Pediatrics 2009; 123: 5: 764-769.
  16. Buyukokuroglu M.E., Gepdiremen A., Tastekin A., Ors R. Pyridoxine may protect the cerebellar granular cells against glutamate-induced toxicity. Int J Vitam Nutr Res 2007; 77: 5: 336-340.
  17. Cetinkaya M., Alkan T., Ozyener F. et al. Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model. Neonatology 2011; 99: 4: 302-310.
  18. Chan M.T. Magnesium sulfate for brain protection during temporary cerebral artery occlusion. Acta Neurochir Suppl 2005; 95: 107-111.
  19. Chen S.D., Chen Y.B., Peng Y. et al. Role of PI3K/Akt signaling in the protective effect of magnesium sulfate against ischemia-perfusion injury of small intestine in rats. Chin Med J (Engl) 2010; 123: 11: 1447-1452.
  20. Committee O. Committee Opinion No. 455: Magnesium sulfate before anticipated preterm birth for neuroprotection. Obstet Gynecol 2010; 115: 3: 669-671.
  21. Domeniconi M., Hempstead B.L., Chao M.V. Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci 2007; 34: 2: 271-279.
  22. Doyle L.W., Crowther C.A., Middleton P., Marret S. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2009; 1: CD004661.
  23. Doyle L.W., Crowther C.A., Middleton P. Antenatal magnesium sulfate and neurologic outcome in preterm infants: a systematic review. Obstet Gynecol 2009; 113: 6: 1327-1333.
  24. Dribben W.H., Creeley C.E., Wang H.H. High dose magnesium sulfate exposure induces apoptotic cell death in the developing neonatal mouse brain. Neonatology 2009; 96: 1: 23-32.
  25. Dyckner T., Wester P.O. Effect of magnesium on blood pressure. Br Med J 1983; 286: 6381: 1847-1849.
  26. Ernfors P., Kucera J. Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice. Int J Dev Biol 1995; 39: 5: 799.
  27. Friedlich D. Retrospective analysis of parenteral magnesium sulfate administration in decreased incidence of clinical and neuroradiological cerebral vasospasm: a single center experience. Neurol Res 2009; 31: 6: 621-625.
  28. Furukawa Y., Kasai N., Torimitsu K. Effect of Mg2+ on neural activity of rat cortical and hippocampal neurons in vitro. Magnes Res 2009; 22: 3: 174-181.
  29. Garnier Y. Neuroprotective effects of magnesium on metabolic disturbances in fetal hippocampal slices after oxygen-glucose deprivation: mediation by nitric oxide system. J Soc Gynecol Investig 2002; 9: 2: 86-92.
  30. Geng M.Y., Saito H., Katsuki H. Effects of vitamin B6 and its related compounds on survival of cultured brain neurons. Neurosci Res 1995; 24: 1: 61-65.
  31. Gougoulias N., Hatzisotiriou A. Magnesium administration provokes motor unit survival, after sciatic nerve injury in neonatal rats. BMC Musculoskelet Disord 2004; 5: 1: 33.
  32. Hasegawa T., Mikoda N., Kitazawa M., LaFerla F.M. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One 2010; 5: 1: 8593.
  33. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001; 24: 677-736.
  34. Huang C.Y. Role of ERK signaling in the neuroprotective efficacy of magnesium sulfate treatment during focal cerebral ischemia in the gerbil cortex. Clin J Physiol 2010; 53: 5: 299.
  35. Ibanez C.F. Jekyll-Hyde neurotrophins: the story of proNGF. Trends Neurosci 2002; 25: 6: 284.
  36. Jee S.H., Miller E.R. 3rd, Guallar E. et al. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. Am J Hypertens 2002; 15: 8: 691-696.
  37. Kang S.W., Choi S.K., Park E., Chae S.J. Neuroprotective effects of magnesium-sulfate on ischemic injury mediated by modulating the release of glutamate and reduced of hyperreperfusion. Brain Res 2011; 1371: 121-128.
  38. Knijn N., Tol J., Koopman M. The effect of prophylactic calcium and magnesium infusions on the incidence of neurotoxicity and clinical outcome of oxaliplatin-based systemic treatment in advanced colorectal cancer patients. Eur J Cancer 2011; 47: 3: 369-374.
  39. Kuypers N.J., Hoane M.R. Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat. J Neurotrauma 2010; 27: 7: 1275-1282.
  40. Lazaridis C., Naval N. Risk factors and medical management of vasospasm after subarachnoid hemorrhage. Neurosurg Clin N Am 2010; 21: 2: 353-364.
  41. Locksley R.M., Killeen N., Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104: 4: 487-501.
  42. Luthringer C., Rayssiguier Y., Gueux E. Berthelot A. Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats. Br J Nutr 1988; 59: 2: 243-250.
  43. Lyden P., Wahlgren N.G. Mechanisms of action of neuroprotectants in stroke. J Stroke Cerebrovasc Dis 2000; 9: 6 Pt 2: 9-14.
  44. Ma L. Magnesium sulphate in the management of patients with aneurysmal subarachnoid haemorrhage: a meta-analysis of prospective controlled trials. Brain Inj 2010; 24: 5: 730-735.
  45. Magee L., Sawchuck D., Synnes A., von Dadelszen P. SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection. J Obstet Gynaecol Can 2011; 33: 5: 516-529.
  46. Marret S., Chollat C., Leveque C., Marpeau L. Prevention of cerebral palsy using magnesium sulfate in pre-term newborns. Arch Pediat 2011; 18: 3: 324-330.
  47. Martin H., Uring-Lambert B., Adrian M. et al. Effects of long-term dietary intake of magnesium on oxidative stress, apoptosis and ageing in rat liver. Magnes Res 2008; 21: 2: 124-130.
  48. McDonald J.W. Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci Lett 1990; 109: 1-2: 234-238.
  49. Meloni B.P., Campbell K. In search of clinical neuroprotection after brain ischemia: the case for mild hypothermia (35 degrees C) and magnesium. Stroke 2009; 40: 6: 2236-2240.
  50. Ozdemir M., Cengiz S.L., Gurbilek M. Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma. Magnes Res 2005; 18: 3: 170-174.
  51. Petersen B., Schroll M., Christiansen C., Transbol I. Serum and erythrocyte magnesium in normal elderly danish people. Relationship to blood pressure and serum lipids. Acta Med Scand 1977; 201: 1-2: 31-34.
  52. Pryde P.G., Mittendorf R. Contemporary usage of obstetric magnesium sulfate: indication, contraindication, and relevance of dose. Obstet Gynecol 2009; 114: 3: 669-673.
  53. Resnick L.M. Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations. Proc Natl Acad Sci USA 1984; 81: 20: 6511-6515.
  54. Rude R., Manoogian C., Ehrlich L. Mechanisms of blood pressure regulation by magnesium in man. Magnesium 1989; 8: 5-6: 266-273.
  55. Sen A.P., Gulati A. Use of magnesium in traumatic brain injury. Neurotherapeutics 2010; 7: 1: 91-99.
  56. Sendowski I. Magnesium therapy in acoustic trauma. Magnes Res 2006; 19: 4: 244-254.
  57. Solaroglu I. Magnesium sulfate treatment decreases caspase-3 activity after experimental spinal cord injury in rats. Surg Neurol 2005; 64 Suppl 2: 17-21.
  58. Standley C.A., Batia L., Yueh G. Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia. J Matern Fetal Neonatal Med 2006; 19: 3: 171-176.
  59. Stippler M., Fischer M.R., Puccio A.M. Serum and cerebrospinal fluid magnesium in severe traumatic brain injury outcome. J Neurotrauma 2007; 24: 8: 1347-1354.
  60. Tam M., Gomez S., Gonzalez-Gross M., Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr 2003; 57: 10: 1193-1197.
  61. Tong G.M. Magnesium deficiency in critical illness. J Intensive Care Med 2005; 20: 1: 3-17.
  62. Torshin I.Yu. Bioinformatics in the post-genomic era: physiology and medicine. Nova Biomedical Books 2007; 1-20.
  63. Torshin I.Yu., Gromova O.A. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science 2009; 250.
  64. Torshin I.Yu. Bioinformatics in the post-genomic era: sensing the change from molecular genetics to personalized medicine. New York: Nova Biomedical Books 2009.
  65. Turkoglu O.F. A comparative study of treatment for brain edema: magnesium sulphate versus dexamethasone sodium phosphate. J Clin Neurosci 2008; 15: 1: 60-65.
  66. Van den Bergh W.M. Magnesium and aspirin treatment in patients with subarachnoid haemorrhage. Comparison of effects after endovascular and neurosurgical aneurysm occlusion. J Neurol 2009; 256: 2: 213-216.
  67. Van Leer E.M., Seidell J.C., Kromhout D. Dietary calcium, potassium, magnesium and blood pressure in the Netherlands. Int J Epidemiol 1995; 24: 6: 1117-1123.
  68. Wang M., Yang Y., Dong Z. et al. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo. Neuroreport 2006; 17: 12: 1343-1346.
  69. Weglicki W.B., Phillips T.M. Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol Cell Biochem 1992; 110: 2: 169-173.
  70. Weglicki W.B., Mak I.T., Phillips T.M. Blockade of cardiac inflammation in Mg2+ deficiency by substance P receptor inhibition. Circ Res 1994; 74: 5: 1009-1013.
  71. Wiseman D.B., Dailey A.T. Magnesium efficacy in a rat spinal cord injury model. J Neurosurg Spine 2009; 10: 4: 308-314.
  72. Wong G.K., Lam C.W., Chan M.T. et al. The effect of hypermagnesemic treatment on cerebrospinal fluid magnesium level in patients with aneurysmal subarachnoid hemorrhage. Magnes Res 2009; 22: 2: 60-65.
  73. Wu G., Tian H., Han K. et al. Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension. Clin Exp Hypertens 2006; 28: 5: 489-497.
  74. Yamada K., Nabeshima T. Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci 2003; 91: 4: 267-270.
  75. Yamashima T., Zhao L., Wang X.D. et al. Neuroprotective effects of pyridoxal phosphate and pyridoxal against ischemia in monkeys. Nutr Neurosci 2001; 4: 5: 389.
  76. Yang T.T., Wang S.J. Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism? J Pharmacol Exp Ther 2009; 331: 1: 244-254.
  77. Zelaporte B., Bruel H. Effect of magnesium sulphste on mortality and neurologic morbidity of the very-preterm newborn (of less than 33 weeks) with two-yaer neurological jutcome: results of the prospective PREMAG trial. Gynecol Obstet Fertil 2008; 36: 3: 278-288.
  78. Zou L.P., Wang X., Dong C.H., Chen C. Three-week combination treatment with ACTH + magnesium sulfate versus ACTH monotherapy for infantile spasms: a 24-week, randomized, open-label, follow-up study in China. Clin Ther 2010; 32: 4: 692-700.

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