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Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Sivertseva S.A.

Tiumenskiĭ oblastnoĭ tsentr rasseiannogo skleroza

Association analysis between candidate genes for multiple sclerosis and brain MRI parameters

Authors:

Boĭko A.N., Sivertseva S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(1): 84‑88

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ASSOCIATION ANALYSIS BETWEEN CANDIDATE GENES FOR MULTIPLE SCLEROSIS AND BRAIN MRI PARAMETERS
ASSOCIATION ANALYSIS BETWEEN CANDIDATE GENES FOR MULTIPLE SCLEROSIS AND BRAIN MRI PARAMETERS

To cite this article:

Boĭko AN, Sivertseva SA. Association analysis between candidate genes for multiple sclerosis and brain MRI parameters. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(1):84‑88. (In Russ.)

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
 
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We studied efficacy and tolerability of the combined drug omaron (25 mg of cinnarizine and 400 mg of piracetam in one tablet) in patients with multiple sclerosis. The dosage of the drug was 1 tablet 3 times a day during 12 weeks in 33 patients (mean age 35.3±4.2 years) of the index group. A comparison group consisted of 27 patients matched for demographic and clinical characteristics who did not receive nootropics during the study. None of patients included in the study received disease modifying drugs. The significant (p<0.05) decrease in the severity of chronic fatigue syndrome (by 28.6% compared to baseline), improvement (p<0.05) of cognitive functions (increase of MMSE scores by 9.4%) were found in the index group compared to the comparison one. The statistically significant changes in the severity of disability assessed by EDSS were not observed. Omaron was well-tolerated with no serious adverse-effects.

Keywords:

multiple sclerosis
HLA-DR
MRI
internuclear index

Authors:

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Sivertseva S.A.

Tiumenskiĭ oblastnoĭ tsentr rasseiannogo skleroza

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