The effect of insomnia on mild cognitive impairment in patients with vascular risks: results of a three-year longitudinal study

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

SPIN RSCI: 5084-1379
ORCID: 0000-0003-3259-3691

Shindryaeva N.N.

Sechenov First Moscow State Medical University (Sechenov University);
City Clinic No. 2

ORCID: 0000-0001-6560-2756

Fateeva V.V.

Federal scientific and clinical center for resuscitation and rehabilitology;
Pirogov Russian National Research Medical University

ORCID: 0000-0001-9935-3962

The effect of insomnia on mild cognitive impairment in patients with vascular risks: results of a three-year longitudinal study

Authors:

Vorobeva O.V., Shindryaeva N.N., Fateeva V.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3‑2): 30‑36

DOI: 10.17116/jnevro202412403230

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To cite this article:

Vorobeva OV, Shindryaeva NN, Fateeva VV. The effect of insomnia on mild cognitive impairment in patients with vascular risks: results of a three-year longitudinal study. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3‑2):30‑36. (In Russ.)
https://doi.org/10.17116/jnevro202412403230

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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OBJECTIVE

To assess the dynamics of sleep parameters based on the analysis of three items of HDRS-17, designed to measure the severity of insomnia, during 36 months of follow-up and their relationship with indicators of the cognitive phenotype in patients with vascular risk factors.

MATERIAL AND METHODS

The longitudinal study included 51 patients (mean age 57.7±6.2 years, 19 (37.3%) men)) who met the inclusion criteria. All participants underwent a general clinical examination with assessment of vascular risks and neuropsychological testing using the Montreal Cognitive Assessment (MoCA) and HDRS-17 at baseline and after 36 months. During the study, patients received stable basic therapy to prevent modifiable vascular risk factors. Sleeping pills were taken sporadically when there were complaints of problems falling asleep.

RESULTS

During the 36-month study, as vascular cognitive impairment progressed from 23.7±2.6 to 22.1±2.4 points on the MoCA scale (p=0.01), mainly due to decreased attention (p=0.01), executive functions (EF) (p=0.01), memory (p=0.02), speech (p=0.02), an increase in sleep disturbances was observed (item 4: 0.8±0.02 to 1.9±0.1 points, p=0.01; point 5: 0.6±0.02 to 1.7±0.1 points, p=0.01) and depression (7.5±0.5 to 13.7±3.0 points, p=0.01) in patients with vascular risks. A strong inverse correlation was revealed between the values of items 4, 5, 6 on the HDRS-17 and the average MoCA-total scores (r=–0.85; r=–0.87; r=–0.8 (p<0.05)), memory index (r=–0.8; r=–0.75; r=–0.81 (p<0.05)), attention index (r=–0.88; r=–0.86; r=–0.83 (p<0.05)), index of executive functions (r=–0.87; r=–0.85; r=–0.8 (p<0.05)), respectively.

CONCLUSION

The progression of cognitive impairment is associated with worsening insomnia disorders and depression in patients with vascular risks.

Keywords:

insomnia

cognitive impairment

depression

vascular risk factors

Authors:

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

SPIN RSCI: 5084-1379
ORCID: 0000-0003-3259-3691

Shindryaeva N.N.

Sechenov First Moscow State Medical University (Sechenov University);
City Clinic No. 2

ORCID: 0000-0001-6560-2756

Fateeva V.V.

Federal scientific and clinical center for resuscitation and rehabilitology;
Pirogov Russian National Research Medical University

ORCID: 0000-0001-9935-3962

Received:

27.11.2023

Accepted:

30.11.2023

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