The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Voznyuk I.A.

Pivovarova L.P.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Gogoleva E.A.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Osipova I.V.

Altai State Medical University

Ariskina O.B.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Morozova E.M.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Chernyavsky I.V.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Markelova E.V.

Pacific State Medical University

Biomarkers of brain damage and inflammation in patients with acute cerebral ischemia

Authors:

Voznyuk I.A., Pivovarova L.P., Gogoleva E.A., Osipova I.V., Ariskina O.B., Morozova E.M., Chernyavsky I.V., Markelova E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(8‑2): 54‑60

DOI: 10.17116/jnevro202212208254

Read: 3237 times

Download PDF (RU)
Contact the author
Table of contents

BIOMARKERS OF BRAIN DAMAGE AND INFLAMMATION IN PATIENTS WITH ACUTE CEREBRAL ISCHEMIA
BIOMARKERS OF BRAIN DAMAGE AND INFLAMMATION IN PATIENTS WITH ACUTE CEREBRAL ISCHEMIA

To cite this article:

Voznyuk IA, Pivovarova LP, Gogoleva EA, et al. Biomarkers of brain damage and inflammation in patients with acute cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(8‑2):54‑60. (In Russ.)
https://doi.org/10.17116/jnevro202212208254

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Early anti­thrombotic protection of the brain in patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):5-10
Therapeutic pote­ntial of quercetin and its deri­vatives against COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):44-50
Identification of depression biomarkers: Prospects for use in clinical practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):51-55
Biomarkers of acute cere­bral damage in complex diagnosis of sepsis-associated ence­phalopathy. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):6-13
Mathematical mode­ling of outcomes in patients with clinical combination of ischemic stroke and COVID-19 complicated by multiple organ failure. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):42-49
Socio-economic damage caused by elevated low-density lipo­protein cholesterol levels. Medi­cal Technologies. Asse­ssment and Choice. 2025;(2):88-98
Asso­ciation of cortisol levels with psychopathological features of depression and therapeutic response in female patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):45-54
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Prediction of mortality in severe ischemic stroke during COVID-19 in patients with multiorgan dysfunction. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):120-127
A clinical case of treating a patient with severe ischemic stroke and cancer. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):114-117
Abstract:

OBJECTIVE

To study the pathogenetic and clinical significance of factors of hypoxic brain damage and inflammatory mediators in the development of stroke, to improve the diagnosis using laboratory markers of brain damage and inflammation in patients with acute cerebrovascular accident.

MATERIAL AND METHODS

We examined 55 people with stroke of the ischemic type at the age of 74 (67; 80) years, the comparison group consisted of 25 volunteers at the age of 65.0 (62.0; 66.5) years. Depending on the outcome of ischemic stroke, patients were assigned to the discharged group or to the deceased group. Blood serum and cerebrospinal fluid (CSF) S100b protein, glial fibrillar acidic protein and interleukin-6 (IL-6); blood serum neurospecific enolase, and cortisol and C-reactive protein (CRP) were determined. Clinical blood test and assessment of fibrinogen content were performed on days 1, 3 and 10 of stroke.

RESULTS

There is an increase in the levels of markers of brain tissue damage and systemic inflammation in the blood and CSF in response to cerebral ischemia that reflects the synergy of these pathological processes in patients with stroke, their association with the severity of stroke and its outcome.

CONCLUSION

The results indicate that the postischemic release of neurospecific proteins, an increase in the content of IL-6, CRP, and cortisol make it possible to additionally characterize the severity of stroke and the body’s response to damage, and predict the outcome of the disease.

Keywords:

ischemic stroke
inflammation
S100b
GFAP
NSE
IL-6
CRP
cortisol

Authors:

Voznyuk I.A.

Pivovarova L.P.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Gogoleva E.A.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Osipova I.V.

Altai State Medical University

Ariskina O.B.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Morozova E.M.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Chernyavsky I.V.

Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine

Markelova E.V.

Pacific State Medical University

Received:

19.04.2022

Accepted:

27.04.2022

Close metadata

References:

  1. Voznyuk IA, Yanishevsky SN, Chechulov PV, et al. Ishemicheskiy insul’t: klinicheskiye rekomendatsii po pervichnoy i vtorichnoy profilaktike: metodicheskoye posobiye dlya vrachey. Sankt-Peterburgskiy NII skoroy pomoshchi im. I.I. Dzhanelidze. SPb.: Firma «Stiks»; 2018;32. (In Russ.).
  2. Isgrò MA, Bottoni P, Scatena R. Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects. Adv Exp Med Biol. 2015;867:125-143.  https://doi.org/1007/978-94-017-7215-0_9
  3. Hu X, De Silva TM, et al. Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circ Res. 2017;120(3):449-471.  https://doi.org/10.1161/CIRCRESAHA.116.308427
  4. Perdiguero EG, Geissmann F. The development and maintenance of resident macrophages. Nature Immunology. 2016;17(1):2-8.  https://doi.org/10.1038/ni.3341
  5. Brouns R, De Vil B, Cras P, et al. Neurobiochamical markers of brain damage in cerebrospinal fluid of ischemic stroke patients. Clinical Chemistry. 2010;56(3):451-458.  https://doi.org/10.1373/clinchem.2009.134122
  6. Worthmann H, Tryc AB, Goldbecker A, et al. The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome. Cerebrovasc Dis. 2010;30(1):85-92.  https://doi.org/10.1159/000314624
  7. Lambertsen KL, Biber K, Finsen B. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab. 2012;32(9):1677-1698. https://doi.org/10.1038/jcbfm.2012.88
  8. Shtark MB. Mozgospetsificheskiye belki (antigeny) i funktsii neyrona. M.: Meditsina; 1985;256. (In Russ.).
  9. Herrmann M, Vos P, Wunderlich MT, et al. Release of Glial Tissue — Specific Proteins After Acute Stroke. A Comparative Analysis of Serum Concentrations of Protein S-100B and Glial Fibrillary Acidic Protein. Stroke. 2000;31(11):2670-2677. https://doi.org/10.1161/01.str.31.11.2670
  10. Chereshnev VA, Chereshneva MV. Immunological mechanisms of local inflammation. Meditsinskaya Immunologiya. 2011;13(6):557-568. (In Russ.). https://doi.org/10.15789/1563-0625-2011-6-557-568
  11. Braun M, Vaibhav K, Saad NM, et al. White matter damage after traumatic brain injury: A role for damage associated molecular patterns. Biochim Biophys Acta Mol Basis Dis. 2017;1863(10):2614-2626. https://doi.org/10.1016/j.bbadis.2017.05.020
  12. Vasil’yev YuG, Berestov DS. Gomeostaz i plastichnost’ mozga. Izhevsk: FGBOU VPO Izhevskaya GSKHA; 2011;216. (In Russ.). https://doi.org/10.1111/j.1471-4159.1978.tb07028.x
  13. Hülya Kıray, Susan L. Lindsay, Sara Hosseinzadehand Susan C. Barnett. The multifaceted role of astrocytes in regulating myelination. Exp Neurol. 2016;283(PtB):541-549.  https://doi.org/10.1016/j.expneurol.2016.03.009
  14. Bianchi R, Verzini M, Garbuglia M, et al. Mechanism of S100 protein-dependent inhibition of glial fibrillary acidic protein (GFAP) polymerization. Biochim Biophys Acta. 1994;(3):354-360.  https://doi.org/10.1016/0167-4889(94)90095-7
  15. Ren C, Kobeissy F, Alawieh ALi, et al. Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients. Sci Rep. 2016;14(6):24588. https://doi.org/10.1038/srep24588
  16. Gójska-Grymajło A, Zieliński M, Wardowska A, et al. CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients. Neurochem Int. 2018;120:134-139.  https://doi.org/10.1016/j.neuint.2018.08.009
  17. Kanavaki A, Spengos K, Moraki M, et al. Serum Levels of S100b and NSE Proteins in Patients with Non-Transfusion-Dependent Thalassemia as Biomarkers of Brain Ischemia and Cerebral Vasculopathy. Int J Mol Sci. 2017;18(12):23-28.  https://doi.org/10.3390/ijms18122724
  18. Pelinka LE, Hertz H, Mauritz W, et al. Nonspecific increase of systemic neuron-specific enolase after trauma: clinical and experimental findings. Shock. 2005;24(2):119-123.  https://doi.org/10.1016/j.resuscitation.2004.01.012
  19. Gumusoglu SB, Fine RS, Murray SJ, et al. The role of IL-6 in neurodevelopment after prenatal stress. Brain Behav Immun. 2017;65:274-283.  https://doi.org/10.1016/j.bbi.2017.05.015
  20. Dzaye OD, Hu F, Derkow K, et al. Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6. Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling. J Neuropathol Exp Neurol. 2016;75(5):429-440.  https://doi.org/10.1093/jnen/nlw016
  21. Gruol DL. IL-6 regulation of synaptic function in the CNS. Neuropharmacology. 2015;96(Pt A):42-54.  https://doi.org/10.1016/j.neuropharm.2014.10.023
  22. Ketlinskiy SA, Simbirtsev AS. Tsitokiny. SPb.: OOO «Izdatel’stvo Foliant»; 2008;552. (In Russ.).
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.