Family history of affective disorders, the gender factor and clinical characteristics of depression

Mazo GE, Kasyanov ED, Nikolishin AE, et al. Family history of affective disorders, the gender factor and clinical characteristics of depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(5‑2):75‑83. (In Russ.)
https://doi.org/10.17116/jnevro202112105275

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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OBJECTIVE

Analysis of clinical features of development and course of depression in patients with FH of mood disorders taking into account sex differences.

MATERIAL AND METHODS

This multicenter cross-sectional study included patients over 18 years of age with depressive episode/recurrent depressive disorder. Clinical characteristics of depression, presence of comorbid mental illness and family history (FH) information were obtained in a structured clinical interview.

RESULTS

One hundred and seventy-one patients (mean age (M (SD)) 40.87 (15.86) y.o.), including 64.5% of women, were enrolled in the study. FH was revealed in 30.2% of patients. The proportion of FH did not differ in men and women (p=0.375). Generalized anxiety disorder (GAD) was more frequent in FH positive patients (p=0.016). Logistic regression also revealed that FH is a risk factor for concomitant GAD (p=0.019, OR=2.4). The GLM demonstrated a significant joint effect of FH and sex on the maximum duration of a depressive episode (p=0.044), as well on the number of suicide attempts (p=0.055) and the number of depressive episodes as a trend (p=0.072).

CONCLUSION

We have demonstrated the specific interaction of FH of mood disorders with sex on clinical course of depression. Thus, the manifestation of a genetic influence on the clinical phenotype of depression can be significantly moderated by sex.

Keywords:

depression

family history

sex

mood disorders

genetics

Authors:

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-7910-9129

Kasyanov E.D.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-4658-2195

Nikolishin A.E.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-6871-1234

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5282-2036

Shmukler A.B.

Serbsky National Medical Research Center of Psychiatry and Narcology

Golimbet V.E.

Mental Health Research Center

ORCID: 0000-0002-9960-7114

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

ORCID: 0000-0001-5618-4206

Kibitov A.O.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-8771-625X

Received:

16.11.2020

Accepted:

02.12.2020

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