Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region

Smagina I.V.; Lunev K.V.; Elchaninova S.A.

doi:https://doi.org/10.17116/jnevro202012007261

Smagina I.V.

Altai State Medical University;
Regional Clinical Hospital

SPIN RSCI: 5949-1170
Scopus AuthorID: 6504407231
ResearcherID: S-4084-2016
ORCID: 0000-0002-7947-4529

Lunev K.V.

Altai State Medical University

ORCID: 0000-0002-1875-3890

Elchaninova S.A.

Altai State Medical University

SPIN RSCI: 9015-4554
Scopus AuthorID: 6506172875
ORCID: 0000-0003-2730-615X

Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region

Authors:

Smagina I.V., Lunev K.V., Elchaninova S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7‑2): 61‑66

DOI: 10.17116/jnevro202012007261

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To cite this article:

Smagina IV, Lunev KV, Elchaninova SA. Association between vitamin D status and CYP27b1 and CYP24A1 gene polymorphisms in patients with multiple sclerosis in the Altai region. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7‑2):61‑66. (In Russ.)
https://doi.org/10.17116/jnevro202012007261

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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OBJECTIVE

To evaluate the relationship between vitamin D status and polymorphisms of the genes encoding enzymes of the vitamin D metabolism CYP27B1 (rs703842) and CYP24A1 (rs2248359) in patients with MS.

MATERIAL AND METHODS

Caucasians born and living in the Altai region of the Russian Federation, 90 patients with relapsing—remitting MS and 87 volunteers without MS took part in the study. The level of 25-hydroxyvitamin D (25(OH)D) in the blood serum was measured by enzyme immunoassay. Genotyping was carried out using the TaqMan probe method.

RESULTS

A level of 25(OH)D of less than 30 ng/ml was more common among patients with MS compared with the control. A relationship between the MS risk and the TC genotype CYP27B1 (rs703842) was identified. In patients with MS and in the control, the GA genotype CYP24A1 (rs2248359) was associated with a 25(OH)D level of less than 30 ng/ml.

CONCLUSION

The high prevalence of vitamin D deficiency in patients with MS may be associated with the genetically determined features of CYP27B1.

Keywords:

multiple sclerosis

vitamin D

CYP27B1

CYP24A1

Authors:

Smagina I.V.

Altai State Medical University;
Regional Clinical Hospital

SPIN RSCI: 5949-1170
Scopus AuthorID: 6504407231
ResearcherID: S-4084-2016
ORCID: 0000-0002-7947-4529

Lunev K.V.

Altai State Medical University

ORCID: 0000-0002-1875-3890

Elchaninova S.A.

Altai State Medical University

SPIN RSCI: 9015-4554
Scopus AuthorID: 6506172875
ORCID: 0000-0003-2730-615X

Received:

08.04.2020

Accepted:

09.04.2020

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