A role of vascular risk factors in the development of peripheral vestibulopathy

Kutlubaev M.A.; Zamergrad M.V.

doi:https://doi.org/10.17116/jnevro201911909285

Close metadata

Recommended articles:

Diagnosis of labyrinth hydrops in patients on different stages of Meniere’s disease. Russian Bulletin of Otorhinolaryngology. 2025;(3):24-29

Recurrent pain syndromes in adolescents of different ages. Russian Journal of Pain. 2025;(2):24-31

Prophylactic treatment of migraine in real clinical practice. Russian Journal of Pain. 2025;(2):63-69

Biofeedback in complex therapy of pain syndromes. Russian Journal of Pain. 2025;(2):70-75

Vascular endothelial growth factor in episodic and chronic migraine: new approaches to understanding pathogenesis. Russian Journal of Pain. 2025;(3):17-21

The Central Sensitization Inventory: modification for tension-type headache, migraine and cervicogenic headache. Russian Journal of Pain. 2025;(3):22-32

Orexin A in migraine: associations with clinical features of disease and comorbid disorders. Russian Journal of Pain. 2025;(3):42-51

Clinical and laboratory characteristics of migraine associated with antiphospholipid syndrome and genetic thrombophilia. Russian Journal of Pain. 2025;(3):52-57

The role of TRP channels in migraine. Russian Journal of Pain. 2025;(3):93-103

Epidemiology and some clinical aspects of primary headaches in children and adolescents. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):28-35

Abstract:

The development of peripheral vestibular disorders are often thought to be associated with vascular mechanisms, taking into account terminal type of inner ear blood supply and other predisposing factors. A number of studies indicates a high frequency of vascular risk factors in the patients with vestibular neuronitis and benign paroxysmal positional vertigo (BPPV). According to other results, migraine is widely spread among patients with Meniere’s disease and BPPV. However currently there is no evidence for casual relationship between vascular factors and development of peripheral vestibulopathy. The only exclusion is labyrinthine infarction, which develops as a result of posterior circulation disorder. More research is needed in this area.

Keywords:

vestibulopathy

migraine

labyrinthine infarction

vestibular neuronitis

Meniere’s disease

benign paroxysmal positional vertigo

vascular factors

Authors:

Kutlubaev M.A.

Nevrologicheskoe otdelenie Respublikanskoĭ klinicheskoĭ bol'nitsy im. G.G. Kuvatova

SPIN RSCI: 4713-0312
Scopus AuthorID: 9241930700
ORCID: 0000-0003-1001-2024

Zamergrad M.V.

SPIN RSCI: 4521-6350
Scopus AuthorID: 35773896900
ORCID: 0000-0002-0193-2243

Close metadata

References:

Luxon LM. Anatomiya i fisiologiya vestibularnoi systemy. Golovokruzhenie. Dix M.R., Hood J.D., Eds. M.: Meditcina; 1987. (In Russ.)
Stratieva OV. Klinicheskaya anatomiya ukha. SPb.: Spetclit; 2004. (In Russ.)
Kim HA, Lee H. Recent advances in understanding audiovestibular loss of a vascular cause. J Stroke. 2017;19:61-66. https://doi.org/10.5853/jos.2016.00857
Liqun Z, Park KH, Kim HJ, Lee SU, Choi JY, Kim JS. Acute unilateral audiovestibulopathy due to embolic labyrinthine infarction. Front Neurol. 2018;9:311. https://doi.org/10.3389/fneur.2018.00311
Kim JS, Cho KH, Lee H. Isolated labyrinthine infarction as a harbinger of anterior inferior cerebellar artery territory infarction with normal diffusion-weighted brain MRI. J Neurol Sci. 2009;278:82-84. https://doi.org/10.1016/j.jns.2008.12.002
Otorinolaringologiya. Natsional’noe rukovodstvo. Ed.ited by Palchun V.T. M.: Goetar-Media; 2008. (In Russ.)
Jeong S-H, Kim H-J, Kim J-S. Vestibular neuritis. Semin Neurol. 2013;33:185-194. https://doi.org/10.1055/s-0033-1354598
Gianoli G, Goebel J, Mowry S, Poomipannit P. Anatomic differences in the lateral vestibular nerve channels and their implications in vestibular neuritis. Otol Neurotol. 2005;26:489-494. https://doi.org/10.1097/01.mao.0000169787.99835.9f
Oron Y, Shemesh S, Shushan S, Cinamon U, Goldfarb A, Dabby R, Ovnat Tamir S. Cardiovascular Risk Factors Among Patients With Vestibular Neuritis. Ann Otol Rhinol Laryngol. 2017;126(8):597-601. https://doi.org/10.1177/0003489417718846
Adamec I, Krbot Skorić M, Handžić J, Habek M. Incidence, seasonality and comorbidity in vestibular neuritis. Neurol Sci. 2015;36:91-95. https://doi.org/10.1007/s10072-014-1912-4
Chung JH, Lee SH, Park CW, Jeong JH, Shin JH. Clinical Significance of Arterial Stiffness and Metabolic Syndrome Scores in Vestibular Neuritis. Otol Neurotol. 2017;38:737-741. https://doi.org/10.1097/MAO.0000000000001352
Chuang YM, Chern CM, Liao WH, Hsu LC, Lien CF, Lirng JF, Shiao AS, Ko JS. Comorbid intracranial vertebral artery asymmetry as a risk factor for severe vestibular neuronitis. Otol Neurotol. 2011;32:478-482. https://doi.org/10.1097/MAO.0b013e31820e785c
Chuang YM, Chan L, Wu HM, Lee SP, Chu YT. The clinical relevance of vertebral artery hypoplasia. Acta Neurol Taiwan. 2012;21(1):1-7.
Koors PD, Thacker LR, Coelho DH. Investigation of seasonal variability of vestibular neuronitis. J Laryngol Otol. 2013;127:968-971. https://doi.org/10.1017/S0022215113001977
Espinosa-Sanchez JM, Lopez-Escamez JA. Menière’s disease. Handb Clin Neurol. 2016;137:257-277. https://doi.org/10.1016/b978-0-444-63437-5.00019-4
Stahle J, Stahle C, Arenberg IK. Incidence of Meniere’s disease. Arch Otolaryngol. 1978;104:99-102. https://doi.org/10.1001/archotol.1978.00790020041009
Stephens D, Mudry A. Meniere’s disorder: A short history. Audiological Medicine. 2012;10:153-159. https://doi.org/10.3109/1651386x.2012.718858
Zamergrad MV, Melnikov OA. Meniere’s disease. Nevrologiya, Neiropsikhiatriya, Psikhosomatica. 2011;3(1):5-8. https://doi.org/10.14412/2074-2711-2011-126
Miller JM, Ren TY, Laurikainen E, Golding-Wood D, Nuttal AL. Hydrops-induced changes in cochlear blood flow. Ann Otol Rhinol Laryngol. 1995;104:476-483. https://doi.org/10.1177/000348949510400611
Brechtelsbauer PB, Ren TY, Miller JM, Nuttal AL. Autoregulation of cochlear blood flow in the hydropic guinea pig. Hear Res. 1995;89:130-136. https://doi.org/10.1016/0378-5955(95)00130-4
Larsen HC, Albers F, Jansson B, Angelborg C, Veldman J. Cochlear blood flow in endolymphatic hydrops. Acta Otolaryngol. 1988;106:404-408. https://doi.org/10.3109/00016488809122263
Munoz DJ, Kendrick IS, Rassam M, Thorne PR. Vesicular storage of adenosine triphosphate in the guinea-pig cochlear lateral wall and concentrations of ATP in the endolymph during sound exposure and hypoxia. Acta Otolaryngol. 2001;121:10-15. https://doi.org/10.1080/000164801300006209
Masutani H, Takahashi H, Sando I. Stria vascularis in Ménière’s disease: a quantitative histopathological study. Auris Nasus Larynx. 1992;19:145-152. https://doi.org/10.1016/s0385-8146(12)80034-4
Kariya S, Cureoglu S, Fukushima H, Nomiya S, Nomiya R, Schachern PA, Nishizaki K, Paparella MM. Vascular findings in the stria vascularis of patients with unilateral or bilateral Ménière’s disease: a histopathologic temporal bone study. Otol Neurotol. 2009;30:1006-1012. https://doi.org/10.1097/mao.0b013e3181b4ec89
Pirodda A, Brandolini C, Raimondi MC, Ferri GG, Modugno GC, Borghi C. Ménière’s disease: update of aetiopathogenetic theories and proposal of a possible model of explanation. Acta Clin Belg. 2010;65:170-175. https://doi.org/10.1179/acb.2010.036
Gortan D. Transcranial Doppler sonography in patients with Ménière’s disease. Acta Medica Croatica. 2000;54:11-14.
Di Berardino F, Alpini DC, Bavera PM, Cecconi P, Farabola M, Mattei V, Ambrosetti U, Cesarani A. Chronic cerebrospinal venous insufficiency in Ménière disease. Phlebology. 2015;30:274-279. https://doi.org/10.1177/0268355514526871
Park JJ, Shen A, Keil S, Kuhl C, Westhofen M. Jugular bulb abnormalities in patients with Meniere’s disease using high-resolution computed tomography. Eur Arch Otorhinolaryngol. 2015;272(8):1879-1884. https://doi.org/10.1007/s00405-014-2996-4
Redfern RE, Brown M, Benson AG. High jugular bulb in a cohort of patients with definite Ménière’s disease. J Laryngol Otol. 2014;128:759-764. https://doi.org/10.1017/s0022215114001820
Karatas A, Kocak A, Cebi IT, Salviz M. Comparison of Endolymphatic Duct Dimensions and Jugular Bulb Abnormalities Between Meniere Disease and a Normal Population. J Craniofac Surg. 2016;27:424-426. https://doi.org/10.1097/scs.0000000000002702
Attanasio G, Cagnoni L, Masci E, Ciciarello F, Diaferia F, Bruno A, Greco A, De Vincentiis M. Chronic cerebrospinal venous insufficiency as a cause of inner ear diseases. Acta Otolaryngol. 2017;137:460-463.
Filipo R, Ciciarello F, Attanasio G, Mancini P, Covelli E, Agati L, Fedele F, Viccaro M. Chronic cerebrospinal venous insufficiency in patients with Ménière’s disease. Eur Arch Otorhinolaryngol. 2015;272:77-82. https://doi.org/10.1007/s00405-013-2841-1
Ghavami Y, Mahboubi H, Yau AY, Maducdoc M, Djalilian HR. Migraine features in patients with Meniere’s disease. Laryngoscope. 2016;126(1):163-168. https://doi.org/10.1002/lary.25344
Foster CA, Breeze RE. The Meniere attack: an ischemia/reperfusion disorder of inner ear sensory tissues. Med Hypotheses. 2013;81:1108-1115. https://doi.org/10.1016/j.mehy.2013.10.015
Li AV, Parkhomenko EV, Barinov AN. Vestibular migraine: diagnostic difficulties and treatment optimization. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2017;117(8):59-66. (In Russ.) https://doi.org/10.17116/jnevro20171178159-66
Kutlubaev MA. Benign paroxysmal positional vertigo. Zhurnal nevr ologii i Psikhiatrii im. S.S. Korsakova. 2016;116(3):73-78. https://doi.org/10.17116/jnevro20161163173-78. (In Russ.)
Wada M, Naganuma H, Tokumasu K, Hashimoto S, Ito A, Okamoto M. Arteriosclerotic changes as background factors in patients with peripheral vestibular disorders. Int Tinnitus J. 2008;14(2):131-134.
Baykara M, Polat C, Oztürk C, Karlıdağ T. An investigation of atherosclerotic markers in patients with posterior semi-circular canal benign paroxysmal positional vertigo. Kulak Burun Bogaz Ihtis Derg. 2014;24:159-163.
Wada M, Naganuma H, Tokumasu K, Okamoto M. Correlation between arteriosclerotic changes and prognosis in patients with peripheral vestibular disorders. Int Tinnitus J. 2009;15:193-195.
Zhang D, Zhang S, Zhang H, Xu Y, Fu S, Yu M, Ji P. Evaluation of vertebrobasilar artery changes in patients with benign paroxysmal positional vertigo. Neuroreport. 2013;24:741-745. https://doi.org/10.1097/WNR.0b013e328364b948
Kao CL, Cheng YY, Leu HB, Chen TJ, Ma HI, Chen JW, Lin SJ, Chan RC. Increased risk of ischemic stroke in patients with benign paroxysmal positional vertigo: a 9-year follow-up nationwide population study in Taiwan. Front Aging Neurosci. 2014;6:108. https://doi.org/10.3389/fnagi.2014.00108
De Reuck J. Vascular risk factors in patients with peripheral vestibular disorders. Acta Neurol Belg. 2010;110(4):303-305.
Picciotti PM, Lucidi D, De Corso E, Meucci D, Sergi B, Paludetti G. Comorbidities and recurrence of benign paroxysmal positional vertigo: personal experience. Int J Audiol. 2016;55:279-284. https://doi.org/10.3109/14992027.2016.1143981
Korkmaz M, Korkmaz H. Cases requiring increased number of repositioning maneuvers in benign paroxysmal positional vertigo. Braz J Otorhinolaryngol. 2016;82:452-457. https://doi.org/10.1016/j.bjorl.2015.08.018
Faralli M, Cipriani L, Del Zompo MR, Panichi R, Calzolaro L, Ricci G. Benign paroxysmal positional vertigo and migraine: analysis of 186 cases. B-ENT. 2014;10:133-139.
Chu CH, Liu CJ, Lin LY, Chen TJ, Wang SJ. Migraine is associated with an increased risk for benign paroxysmal positional vertigo: a nationwide population-based study. J Headache Pain. 2015;16:62. https://doi.org/10.1186/s10194-015-0547-z