The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Vasechkin S.V.

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

Diagnosis and management of essential tremor

Authors:

Vasechkin S.V., Levin O.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6‑2): 64‑72

DOI: 10.17116/jnevro201811806264

Views: 145125

Downloaded: 3690

Download PDF (RU)
Contact the author
Table of contents

DIAGNOSIS AND MANAGEMENT OF ESSENTIAL TREMOR
DIAGNOSIS AND MANAGEMENT OF ESSENTIAL TREMOR

To cite this article:

Vasechkin SV, Levin OS. Diagnosis and management of essential tremor. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6‑2):64‑72. (In Russ.)
https://doi.org/10.17116/jnevro201811806264

 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
МСФ на ЯМ
Close metadata
Recommended articles:
The asso­ciation of single-nucleotide poly­morphism rs6265 of the brain-derived neurotrophic factor gene with clinical features in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):82-88
Asso­ciation of inflammation and chro­nic fati­gue syndrome in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(9):79-87
Como­rbid anxiety diso­rders in patients with neurological pathology: current state of the problem and the role of etifoxine in treatment stra­tegy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):126-136
Nutritional care for patients with neurodegenerative diseases in the outpatient practice of a neurologist. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):76-83

Essential tremor (ET) is the most common extrapyramidal disease and one of the most frequent neurological diseases. The main presentation of ET is a progressive bilateral (kinetic-postural) hand tremor. The prevalence in people over 65 years is 5%, it increases with age up to 22% in people over 95 years. About half of patients with ET have family history. The modern concepts of the pathogenesis, clinical features and differential diagnosis are considered. Possible methods of medical and surgical management are described.

Keywords:

essential tremor
movement disorders
extrapyramidal diseases
neurodegenerative diseases

Authors:

Vasechkin S.V.

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

List of references:

  1. Louis ED. Essential tremor. Lancet Neurol. 2010;9:613-622. https://doi.org/10.1016/S1474-4422(10)70090-9
  2. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534-541. https://doi.org/10.1002/mds.22838
  3. Ferrara J, Jankovic J. Epidemiology and management of essential tremor in children. Paediatr Drugs. 2009;11(5):293-307. https://doi.org/10.2165/11316050-000000000-00000
  4. Bain PG, Findley LJ, Thompson PD, Gresty MA, Rothwell JC, Harding AE, Marsden CD. A study of hereditary essential tremor. Brain. 1994;117:805-824.
  5. Busenbark K, Barnes P, Lyons K, Ince D, Villagra F, Koller WC. Accuracy of reported family histories of essential tremor. Neurology. 1996;47:264-265.
  6. Deng H, Le W, Jancovic J. Genetics of essential tremor. Brain. 2007;130:1456-1464. https://doi.org/10.1093/brain/awm018
  7. Hopfner F, Helmich RC. The etiology of essential tremor: genes versus environment. Parkinsonism Relat Disord. 2018;46:92-96. https://doi.org/10.1016/j.parkreldis.2017.07.014
  8. Louis ED, Vonsattel JP, Honig LS, Ross GW, Lyons KE, Pahwa R. Neuropathologic findings in essential tremor. Neurology. 2006;66(11):1756-1759. https://doi.org/10.1212/01.wnl.0000218162.80315.b9
  9. Kuo SH, Wang J, Tate WJ, Pan MK, Kelly GC, Gutierrez J, Cortes EP, Vonsattel JG, Louis ED, Faust PL. Cerebellar pathology in early onset and late onset essential tremor. Cerebellum. 2017;16:473-482. https://doi.org/10.1007/s12311-016-0826-5
  10. Deuschl G, Wenzelburger R, L.ffler K, Raethjen J, Stolze H. Essential tremor and cerebellar dysfunction clinical and kinematic analysis of intention tremor. Brain. 2000;123:1568-1580.
  11. Stolze H, Petersen G, Raethjen J, Wenzelburger R, Deuschl G. The gait disorder of advanced essential tremor. Brain. 2001;124:2278-2286.
  12. Louis ED, Lee M, Babij R, Ma K, Cortés E, Vonsattel J-PG, Faust PL. Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor. Brain. 2014;137:3142-3148. https://doi.org/10.1093/brain/awu314
  13. Symanski C, Shill HA, Dugger B, Hentz JG, Adler CH, Jacobson SA, Driver-Dunckley E, Beach TG. Essential tremor is not associated with cerebellar Purkinje cell loss. Mov Disord. 2014;29:496-500. https://doi.org/10.1002/mds.25845
  14. Rajput AH, Robinson CA, Rajput ML, Robinson SL, Rajput A. Essential tremor is not dependent up on cerebellar Purkinje cell loss. Parkinsonism Relat Disord. 2012;18:626-628. https://doi.org/10.1016/j.parkreldis.2012.01.013
  15. Jenkins IH, Bain PG, Colebatch JG, Thompson PD, Findley LJ, Frackowiak RS, Marsden CD, Brooks DJ. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol. 1993;34:82-90. https://doi.org/10.1002/ana.410340115
  16. Pagan FL, Butman JA, Dambrosia JM, Hallett M. Evaluation of essential tremor with multi-voxel magnetic resonance spectroscopy. Neurology. 2003; 22;60(8):1344-1347. https://doi.org/10.1212/01.WNL.0000065885.15875.0D
  17. Boecker H, Weindl A, Brooks DJ, Ceballos-Baumann AO, Liedtke C, Miederer M, Sprenger T, Wagner KJ, Miederer I. GABAergic dysfunction in essential tremor: an 11C-flumazenil PET study. J Nucl Med. 2010;51:1030-1035. https://doi.org/10.2967/jnumed.109.074120
  18. Deuschl G, Petersen I, Lorenz D, Christensen K. Tremor in the elderly: essential and aging-related tremor. Mov Disord. 2015;30:1327-1334. https://doi.org/10.1002/mds.26265
  19. Levin OS, Makedonsky PW, Smolentseva IG, Licheva NYu. Neuropsychological disorders in patients with essential tremor. Nevrologicheskij Zhurnal. 2005;4:25-32. (In Russ.)
  20. Shtok VN, Levin OS, Fedorova NV. Ekstrapiramidnye rasstrojstva. M. 2003. (In Russ.)
  21. Elble RJ. What is essential tremor? Curr Neurol Neurosci Rep. 2013;13:353-355. https://doi.org/10.1007/s11910-013-0353-4
  22. Stefansson H, Steinberg S, Petursson H, Gustafsson O, Gudjonsdottir IH, Jonsdottir GA, Palsson ST, Jonsson T, Saemundsdottir J, Bjornsdottir G, Böttcher Y, Thorlacius T, Haubenberger D, Zimprich A, Auff E, Hotzy C, Testa CM, Miyatake LA, Rosen AR, Kristleifsson K, Rye D, Asmus F, Schöls L, Dichgans M, Jakobsson F, Benedikz J, Thorsteinsdottir U, Gulcher J, Kong A, Stefansson K.Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet. 2009;41:277-279. https://doi.org/10.1038/ng.299
  23. Delay C, Tremblay C, Brochu E, Paris-Robidas S, Emond V, Rajput AH, Rajput A, Calon F. Increased LINGO1 in the cerebellum of essential tremor patients. Mov Disord. 2014;29:1637-1647. https://doi.org/10.1002/mds.25819
  24. Golubev VL. Tremor. Nevrologicheskij Zhurnal. 2003;2:4-11. (In Russ.)
  25. Ivanova-Smolenskaya IA. Clinical types of essential tremor. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 1979;79:3:291-298. (In Russ.)
  26. Illarioshkin SN, Ivanova-Smolenskaya IA. Drozhateljnie giperkinezi. Rukovodstvo dlya vrachei. M.: Atmosphera; 2011. (In Russ.)
  27. Deuschl G, Elble R. Essential tremor — neurodegenerative or nondegenerative disease: towards a working definition of ET. Mov Disord. 2009;24:2033-2041. https://doi.org/10.1002/mds.22755
  28. Levin OS. Diagnosis and management of essenrial tremor. Diagnosis and management of extrapyramidal disorders. Pod red. V.N. Shtok M. 2000. (In Russ.)
  29. Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschet G. Consensus Statement on the classification of tremors: from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018;33:75-87. https://doi.org/10.1002/mds.27121
  30. Fekete R, Jankovic J. Revisiting the relationship between essential tremor and Parkinson’s disease. Mov Disord. 2011;26:391-398. https://doi.org/10.1002/mds.23512
  31. Rajput AH, Rozdilsky B, Ang L, Rajput A. Significance of parkinsonian manifestations in essential tremor. Can J Neurol Sci. 1993;20(2):114-117.
  32. Louis ED, Ford B, Lee H, Andrews H, Cameron G. Diagnostic criteria for essential tremor: A population perspective. Arch Neurol. 1998;55:823-828.
  33. Chaudhuri KR, Buxton-Thomas M, Dhawan V, Peng R, Meilak C, Brooks DJ. Long duration asymmetrical postural tremor is likely to predict development of Parkinson’s disease and not essential tremor: clinical follow up study of 13 cases. J Neurol Neurosurg Psychiatry. 2005;76(1):115-117. https://doi.org/10.1136/jnnp.2004.046292
  34. Shahed J, Jankovic J. Exploring the relationship between essential tremor and Parkinson’s disease. Parkinsonism Relat Disord. 2007;13(2):67-76. https://doi.org/10.1016/j.parkreldis.2006.05.033
  35. Benito-León J, Louis ED, Bermejo-Pareja F; Neurological Disorders in Central Spain Study Group. Elderly-onset essential tremor is associated with dementia. Neurology. 2006;23;66(10):1500-1505. https://doi.org/10.1212/01.wnl.0000216134.88617.de
  36. Boecker H, Wills AJ, Ceballos-Baumann A, Samuel M, Thompson PD, Findley LJ, Brooks DJ. The effect of ethanol on alcohol responsive essential tremor: a positron emission tomography study. Ann Neurol. 1996;39:650-658. https://doi.org/10.1002/ana.410390515
  37. Chatterjee A, Jurewicz EC, Applegate LM, Louis ED. Personality in essential tremor: further evidence of non-motor manifestations of the disease. J Neurol Neurosurg Psychiatry. 2004;75(7):958-961. https://doi.org/10.1136/jnnp.2004.037176
  38. Applegate LM, Louis ED. Essential tremor: mild olfactory dysfunction in a cerebellar disorder. Parkinsonism Relat Disord. 2005;11(6):399-402. https://doi.org/10.1016/j.parkreldis.2005.03.003
  39. Busenbark KL, Huber SJ, Greer G, Pahwa R, Koller WC. Olfactory function in essential tremor. Neurology. 1992;42(8):1631-1632.
  40. Grimaldi G, Manto M. Tremor. From pathogenesis to treatment. Morgan & Claypool; 2008.
  41. Zesiewicz TA, Elble RJ, Louis ED, et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology. Neurology. 2011;77:1752-1755. https://doi.org/10.1212/WNL.0b013e318236f0fd
  42. Deuschl G, Raethjen J, Hellriegel H, Elble R. Treatment of patients with essential tremor. Lancet Neurol. 2011;10:148-161. https://doi.org/10.1016/S1474-4422(10)70322-7
  43. Louis ED, Rios E, Henchcliffe C. How are we doing with the treatment of essential tremor (ET)? Persistence of patients with ET on medication: data from 528 patients in three settings. Eur J Neurol. 2010;17:882-884. https://doi.org/10.1111/j.1468-1331.2009.02926.x
  44. Guan XM, Peroutka SJ. Basic mechanisms of action of drugs used in the treatment of essential tremor. Clin Neuropharmacol. 1990;13:210-223.
  45. Alshaikh J, Fishman PS. Revisiting bilateral thalamotomy for tremor. Clin Neurol Neurosurg. 2017;158:103-107. https://doi.org/10.1016/j.clineuro.2017.04.025
  46. Favilla CG, Ullman D, Wagle Shukla A, Foote KD, Jacobson CE IV, Okun MS. Worsening essential tremor following deep brain stimulation: disease progression versus tolerance. Brain. 2012;135:1455-1462. https://doi.org/10.1093/brain/aws026
  47. Ondo W, Almaguer M, Jankovic J, Simpson RK. Thalamic deep brain stimulation: comparison between unilateral and bilateral placement. Arch Neurol. 2001;58:218-222. https://doi.org/10.1001/archneur.58.2.218
  48. Groppa S, Herzog J, Falk D, Riedel C, Deuschl G, Volkmann J. Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor. Brain. 2014;137:109-121. https://doi.org/10.1093/brain/awt304
  49. Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, Schwartz M, Hynynen K, Lozano AM, Shah BB, Huss D, Dallapiazza RF, Gwinn R, Witt J, Ro S, Eisenberg HM, Fishman PS, Gandhi D, Halpern CH, Chuang R, Butts Pauly K, Tierney TS, Hayes MT, Cosgrove GR, Yamaguchi T, Abe K, Taira T, Chang JW. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2016;375:730-739. https://doi.org/10.1056/NEJMoa1600159
  50. Miwa H, Kondo T. T-type calcium channel as a new therapeutic target for tremor. Cerebellum. 2011;10:563-569. https://doi.org/10.1007/s12311-011-0277-y

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.