The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Namestnikova D.D.

Pirogov Russian National Research Medical University, Moscow, Russia

Tairova R.T.

Research Institute of Cerebrovascular pathology and stroke Pirogov Russian National Research Medical University, Moscow, Russia

Cherkashova E.A.

Pirogov Russian National Research Medical University, Moscow, Russia

Sukhinich K.K.

Kol'tsov Institute of Development Biology, Moscow, Russia

Gubskiy I.L.

National Research Institute of Cerebrovascular Pathology and Stroke, Moscow, Russia

Gubskiĭ L.V.

Nauchno-issledovatel'skiĭ institut tserebrovaskuliarnoĭ patologii i insul'ta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Yarygin K.N.

Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

Cell therapy for ischemic stroke. Results of clinical trials and perspectives of clinical application in the Russian Federation

Authors:

Namestnikova D.D., Tairova R.T., Cherkashova E.A., Sukhinich K.K., Gubskiy I.L., Gubskiĭ L.V., Yarygin K.N.

More about the authors

Read: 1538 times


To cite this article:

Namestnikova DD, Tairova RT, Cherkashova EA, Sukhinich KK, Gubskiy IL, Gubskiĭ LV, Yarygin KN. Cell therapy for ischemic stroke. Results of clinical trials and perspectives of clinical application in the Russian Federation. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12‑2):94‑104. (In Russ.)
https://doi.org/10.17116/jnevro201811812294

Recommended articles:
Clinical and gene­tic asso­ciations in patients with non-cardioembolic ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):12-19
Biomarkers of athe­rothrombotic and cardioembolic subtypes of acute ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):20-26
Clinical and tomo­graphic comparisons in patients with apha­sia in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):27-33
Adva­nces in thro­mbectomy in the acute ischemic stroke. Russian Journal of Preventive Medi­cine. 2024;(10):137-143
Improving the effe­ctiveness of treatment of patients with post-stroke apha­sia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):22-28
L-lysine aescinate for back pain: a systematic review. Russian Journal of Pain. 2024;(4):46-54
The effe­ctiveness of drug therapy in the reha­bilitation of patients with post-stroke apha­sia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):132-139
Standardized and scalable method for stro­mal-vascular fraction harvesting from adipose tissue. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(4):76-81
Oxidative stress and antioxidant protection in diso­rders of cere­bral circulation. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):114-119

References:

  1. Savitz SI, Cramer SC, Wechsler L, Consortium S. Stem cells as an emerging paradigm in stroke 3: enhancing the development of clinical trials. Stroke. 2014;45(2):634-649. https://doi.org/10.1161/STROKEAHA.113.003379
  2. Kondziolka D, Steinberg GK, Wechsler L, Meltzer CC, Elder E, Gebel J, Decesare S, Jovin T, Zafonte R, Lebowitz J, Flickinger JC, Tong D, Marks MP, Jamieson C, Luu D, Bell-Stephens T, Teraoka J. Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg. 2005;103(1):38-45. https://doi.org/10.3171/jns.2005.103.1.0038
  3. Savitz SI, Dinsmore J, Wu J, Henderson GV, Stieg P, Caplan LR. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis. 2005;20(2):101-107. https://doi.org/10.1159/000086518
  4. Hess DC, Borlongan CV. Cell-based therapy in ischemic stroke. Expert Rev Neurother. 2008;8(8):1193-1201. https://doi.org/10.1586/14737175.8.8.1193
  5. Tornero D, Tsupykov O, Granmo M, Rodriguez C, Gronning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brustle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z. Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli. Brain. 2017;140(3):692-706. https://doi.org/10.1093/brain/aww347
  6. Bacigaluppi M, Russo GL, Peruzzotti-Jametti L, Rossi S, Sandrone S, Butti E, De Ceglia R, Bergamaschi A, Motta C, Gallizioli M, Studer V, Colombo E, Farina C, Comi G, Politi LS, Muzio L, Villani C, Invernizzi RW, Hermann DM, Centonze D, Martino G. Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes. J Neurosci. 2016;36(41):10529-10544. https://doi.org/10.1523/JNEUROSCI.1643-16.2016
  7. Toyoshima A, Yasuhara T, Kameda M, Morimoto J, Takeuchi H, Wang F, Sasaki T, Sasada S, Shinko A, Wakamori T, Okazaki M, Kondo A, Agari T, Borlongan CV, Date I. Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms. PLoS One. 2015;10(6):e0127302. https://doi.org/10.1371/journal.pone.0127302
  8. Leibacher J, Henschler R. Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells. Stem Cell Res Ther. 2016;7:7. https://doi.org/10.1186/s13287-015-0271-2
  9. De Becker A, Riet IV. Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? World J Stem Cells. 2016;8(3):73-87. https://doi.org/10.4252/wjsc.v8.i3.73
  10. Vendrame M, Gemma C, Pennypacker KR, Bickford PC, Davis Sanberg C, Sanberg PR, Willing AE. Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol. 2006;199(1):191-200. https://doi.org/10.1016/j.expneurol.2006.03.017
  11. Acosta SA, Tajiri N, Hoover J, Kaneko Y, Borlongan CV. Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke. Stroke. 2015;46(9):2616-2627. https://doi.org/10.1161/STROKEAHA.115.009854
  12. Marei HE, Hasan A, Rizzi R, Althani A, Afifi N, Cenciarelli C, Caceci T, Shuaib A. Potential of Stem Cell-Based Therapy for Ischemic Stroke. Front Neurol. 2018;9:34. https://doi.org/10.3389/fneur.2018.00034
  13. Iarygin KN, Iarygin VN. Neurogenesis in the central nervous system and prospects of regenerative neurology. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2012;112(1):4-13. (In Russ.)
  14. Bernstock JD, Peruzzotti-Jametti L, Ye D, Gessler FA, Maric D, Vicario N, Lee YJ, Pluchino S, Hallenbeck JM. Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering. J Cereb Blood Flow Metab. 2017;37(7):2314-2319. https://doi.org/10.1177/0271678X17700432
  15. Cho SR, Suh H, Yu JH, Kim HH, Seo JH, Seo CH. Astroglial Activation by an Enriched Environment after Transplantation of Mesenchymal Stem Cells Enhances Angiogenesis after Hypoxic-Ischemic Brain Injury. Int J Mol Sci. 2016;17(9). https://doi.org/10.3390/ijms17091550
  16. Andres RH, Horie N, Slikker W, Keren-Gill H, Zhan K, Sun G, Manley NC, Pereira MP, Sheikh LA, McMillan EL, Schaar BT, Svendsen CN, Bliss TM, Steinberg GK. Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain. 2011;134(Pt 6):1777-1789. https://doi.org/10.1093/brain/awr094
  17. Kenmuir CL, Wechsler LR. Update on cell therapy for stroke. Stroke Vasc Neurol. 2017;2(2):59-64. https://doi.org/10.1136/svn-2017-000070
  18. Savitz SI, Misra V, Kasam M, Juneja H, Cox CS, Jr., Alderman S, Aisiku I, Kar S, Gee A, Grotta JC. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol. 2011;70(1):59-69. https://doi.org/10.1002/ana.22458
  19. Qiao LY, Huang FJ, Zhao M, Xie JH, Shi J, Wang J, Lin XZ, Zuo H, Wang YL, Geng TC. A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients. Cell Transplant. 2014;23(suppl 1):65-72. https://doi.org/10.3727/096368914X684961
  20. Hess DC, Wechsler LR, Clark WM, Savitz SI, Ford GA, Chiu D, Yavagal DR, Uchino K, Liebeskind DS, Auchus AP, Sen S, Sila CA, Vest JD, Mays RW. Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol. 2017;16(5):360-368. https://doi.org/10.1016/S1474-4422(17)30046-7
  21. Friedrich MA, Martins MP, Araujo MD, Klamt C, Vedolin L, Garicochea B, Raupp EF, Sartori El Ammar J, Machado DC, Costa JC, Nogueira RG, Rosado-de-Castro PH, Mendez-Otero R, Freitas GR. Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke. Cell Transplant. 2012; 21(suppl 1):13-21. https://doi.org/10.3727/096368912X612512
  22. Moniche F, Gonzalez A, Gonzalez-Marcos JR, Carmona M, Pinero P, Espigado I, Garcia-Solis D, Cayuela A, Montaner J, Boada C, Rosell A, Jimenez MD, Mayol A, Gil-Peralta A. Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial. Stroke. 2012;43(8):2242-2244. https://doi.org/10.1161/STROKEAHA.112.659409
  23. Banerjee S, Bentley P, Hamady M, Marley S, Davis J, Shlebak A, Nicholls J, Williamson DA, Jensen SL, Gordon M, Habib N, Chataway J. Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke. Stem Cells Transl Med. 2014;3(11):1322-1330. https://doi.org/10.5966/sctm.2013-0178
  24. Moniche F, Montaner J, Gonzalez-Marcos JR, Carmona M, Pinero P, Espigado I, Cayuela A, Escudero I, de la Torre-Laviana FJ, Boada C, Rosell A, Mayol A, Jimenez MD, Gil-Peralta A, Gonzalez A. Intra-arterial bone marrow mononuclear cell transplantation correlates with GM-CSF, PDGF-BB, and MMP-2 serum levels in stroke patients: results from a clinical trial. Cell Transplant. 2014;23(suppl 1):57-64. https://doi.org/10.3727/096368914X684934
  25. Moniche F, Escudero I, Zapata-Arriaza E, Usero-Ruiz M, Prieto-Leon M, de la Torre J, Gamero MA, Tamayo JA, Ochoa-Sepulveda JJ, Maestre J, Carmona M, Pinero P, Calderon-Cabrera C, Jimenez MD, Gonzalez A, Montaner J. Intra-arterial bone marrow mononuclear cells (BM-MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose-finding, controlled multicenter trial. Int J Stroke. 2015;10(7):1149-1152. https://doi.org/10.1111/ijs.12520
  26. Taguchi A, Sakai C, Soma T, Kasahara Y, Stern DM, Kajimoto K, Ihara M, Daimon T, Yamahara K, Doi K, Kohara N, Nishimura H, Matsuyama T, Naritomi H, Sakai N, Nagatsuka K. Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke: Phase1/2a Clinical Trial in a Homogeneous Group of Stroke Patients. Stem Cells Dev. 2015;24(19):2207-2218. https://doi.org/10.1089/scd.2015.0160
  27. Vahidy FS, Alderman S, Savitz SI. Challenges enrolling patients with acute ischemic stroke into cell therapy trials. Stem Cells Dev. 2013;22(1):27-30. https://doi.org/10.1089/scd.2012.0404
  28. Strbian D, Engelter S, Michel P, Meretoja A, Sekoranja L, Ahlhelm FJ, Mustanoja S, Kuzmanovic I, Sairanen T, Forss N, Cordier M, Lyrer P, Kaste M, Tatlisumak T. Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score. Ann Neurol. 2012;71(5):634-641. https://doi.org/10.1002/ana.23546
  29. Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY, collaborators S. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells. 2010;28(6):1099-1106. https://doi.org/10.1002/stem.430
  30. Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, Onodera R, Waxman SG, Kocsis JD. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain. 2011;134(Pt 6):1790-1807. https://doi.org/10.1093/brain/awr063
  31. Bhasin A, Srivastava MV, Kumaran SS, Mohanty S, Bhatia R, Bose S, Gaikwad S, Garg A, Airan B. Autologous mesenchymal stem cells in chronic stroke. Cerebrovasc Dis Extra. 2011;1(1):93-104. https://doi.org/10.1159/000333381
  32. Bhasin A, Srivastava MV, Mohanty S, Bhatia R, Kumaran SS, Bose S. Stem cell therapy: a clinical trial of stroke. Clin Neurol Neurosurg. 2013;115(7):1003-1008. https://doi.org/10.1016/j.clineuro.2012.10.015
  33. Wang L, Ji H, Li M, Zhou J, Bai W, Zhong Z, Li N, Zhu D, Zhang Z, Liu Y, Wu M. Intrathecal Administration of Autologous CD34 Positive Cells in Patients with Past Cerebral Infarction: A Safety Study. ISRN Neurol. 2013; 128591. https://doi.org/10.1155/2013/128591
  34. Barbosa da Fonseca LM, Gutfilen B, Rosado de Castro PH, Battistella V, Goldenberg RC, Kasai-Brunswick T, Chagas CL, Wajnberg E, Maiolino A, Salles Xavier S, Andre C, Mendez-Otero R, de Freitas GR. Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Exp Neurol. 2010;221(1):122-128. https://doi.org/10.1016/j.expneurol.2009.10.010
  35. Battistella V, de Freitas GR, da Fonseca LM, Mercante D, Gutfilen B, Goldenberg RC, Dias JV, Kasai-Brunswick TH, Wajnberg E, Rosado-de-Castro PH, Alves-Leon SV, Mendez-Otero R, Andre C. Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke. Regen Med. 2011;6(1):45-52. https://doi.org/10.2217/rme.10.97
  36. Rosado-de-Castro PH, Schmidt Fda R, Battistella V, Lopes de Souza SA, Gutfilen B, Goldenberg RC, Kasai-Brunswick TH, Vairo L, Silva RM, Wajnberg E, Alvarenga Americano do Brasil PE, Gasparetto EL, Maiolino A, Alves-Leon SV, Andre C, Mendez-Otero R, Rodriguez de Freitas G, Barbosa da Fonseca LM. Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients. Regen Med. 2013;8(2):145-155. https://doi.org/10.2217/rme.13.2
  37. Prasad K, Sharma A, Garg A, Mohanty S, Bhatnagar S, Johri S, Singh KK, Nair V, Sarkar RS, Gorthi SP, Hassan KM, Prabhakar S, Marwaha N, Khandelwal N, Misra UK, Kalita J, Nityanand S, Inve STSG. Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. Stroke. 2014;45(12):3618-3624. https://doi.org/10.1161/STROKEAHA.114.007028
  38. Sharma A, Sane H, Gokulchandran N, Khopkar D, Paranjape A, Sundaram J, Gandhi S, Badhe P. Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke. Stroke Res Treat. 2014;2014: 234095. https://doi.org/10.1155/2014/234095
  39. Ghali AA, Yousef MK, Ragab OA, Elzamarany EA. Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Stem Cells in Subacute Ischemic Stroke Patients. Front Neurol. 2016;7:228. https://doi.org/10.3389/fneur.2016.00228
  40. Jiang Y, Zhu W, Zhu J, Wu L, Xu G, Liu X. Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of the lesion artery in patients with stroke in the territory of the middle cerebral artery. Cell Transplant. 2013;22(12):2291-2298. https://doi.org/10.3727/096368912X658818
  41. Steinberg GK, Kondziolka D, Wechsler LR, Lunsford LD, Coburn ML, Billigen JB, Kim AS, Johnson JN, Bates D, King B, Case C, McGrogan M, Yankee EW, Schwartz NE. Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study. Stroke. 2016;47(7):1817-1824. https://doi.org/10.1161/STROKEAHA.116.012995
  42. Kalladka D, Sinden J, Pollock K, Haig C, McLean J, Smith W, McConnachie A, Santosh C, Bath PM, Dunn L, Muir KW. Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet. 2016;388(10046):787-796. https://doi.org/10.1016/S0140-6736(16)30513-X
  43. Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J, Hurley C, Barker J, Maiers M, Dehn J, Wang H, Haagenson M, Porter D, Petersdorf EW, Woolfrey A, Horowitz MM, Verneris M, Hsu KC, Fleischhauer K, Lee SJ. Development of an Unrelated Donor Selection Score Predictive of Survival after HCT: Donor Age Matters Most. Biol Blood Marrow Transplant. 2018;24(5):1049-1056. https://doi.org/10.1016/j.bbmt.2018.02.006
  44. Lo Sardo V, Ferguson W, Erikson GA, Topol EJ, Baldwin KK, Torkamani A. Influence of donor age on induced pluripotent stem cells. Nat Biotechnol. 2017;35(1):69-74. https://doi.org/10.1038/nbt.3749
  45. Boltze J, Arnold A, Walczak P, Jolkkonen J, Cui L, Wagner DC. The Dark Side of the Force — Constraints and Complications of Cell Therapies for Stroke. Front Neurol. 2015;6:155. https://doi.org/10.3389/fneur.2015.00155
  46. Guzman R, Janowski M, Walczak P. Intra-Arterial Delivery of Cell Therapies for Stroke. Stroke. 2018;49(5):1075-1082. https://doi.org/10.1161/STROKEAHA.117.018288
  47. Schmidt K, Schulz AS, Debatin KM, Friedrich W, Classen CF. CNS complications in children receiving chemotherapy or hematopoietic stem cell transplantation: retrospective analysis and clinical study of survivors. Pediatr Blood Cancer. 2008;50(2):331-336. https://doi.org/10.1002/pbc.21237

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.