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Diagnostic of prodromal dementia with Levy bodies

Journal: . 2017;117(6‑2): 23‑32

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To cite this article:

Diagnostic of prodromal dementia with Levy bodies. . 2017;117(6‑2):23‑32. (In Russ.)
https://doi.org/10.17116/jnevro20171176223-32

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References:

  1. McKeith IG, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863-1872. https://doi.org/10.1212/01.wnl.0000187889.17253.b1
  2. Levin OS, Vasenina EE, Anikina MA, Makotrova TA. Dementia with Lewy bodies. Zhurn nevrol i psikhiat. 2012;10(2):3-12. (In Russ.).
  3. Zaccai J, McCracken C, Brayne C. A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing. 2005;34(6):561-566. https://doi.org/10.1093/ageing/afi190
  4. Vann Jones S, O’Brien J. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol Med. 2014;44(4):673-83. https://doi.org/10.1017/S0033291713000494
  5. Shim YS, Roe CM, Buckles VD, Morris JC. Clinicopathologic Study of Alzheimer’s Disease: Alzheimer Mimics. J Alzheimers Dis. 2013;35(4):799-811. https://doi.org/10.3233/JAD-121594
  6. Nelson PT, et al. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol. 2010;257(3):359-366. https://doi.org/10.1007/s00415-009-5324-y
  7. Nelson PT, et al. Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. Neurology. 2009;73(14):1127-1133. https://doi.org/10.1212/WNL.0b013e3181bacf9e
  8. Perry RH, Irving D, Blessed G, Perry EK, Fairbairn AF. Clinically and neuropathologically distinct form of dementia in the elderly. Lancet. 1989;1(8630):166. https://doi.org/10.1016/s0140-6736(89)91187-2
  9. Peavy GM, Edland SD, Toole BM, Hansen LA, Galasko DR, Mayo AM. Phenotypic differences based on staging of Alzheimer’s neuropathology in autopsy-confirmed dementia with Lewy bodies. Parkinsonism Relat Disord. 2016;31:72-78. https://doi.org/10.1016/j.parkreldis.2016.07.008
  10. Fujishiro H, Nakamura S, Sato K, Iseki E. Prodromal dementia with Lewy bodies. Geriatr Gerontol Int. 2015;15(7):817-826. https://doi.org/10.1111/ggi.12466
  11. Donaghy PC, McKeith IG. The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis. Alzheimers Res Ther. 2014;21:6(4):46. https://doi.org/10.1186/alzrt274
  12. Donaghy PC, O’Brien JT, Thomas AJ. Prodromal dementia with Lewy bodies. Psychol Med. 2015;45(2):259-268. https://doi.org/10.1017/S0033291714000816
  13. McKeith I, Taylor J, Thomas A, Donaghy P and Kane J. Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology. 2016;29(5): 249-253. https://doi.org/10.1177/0891988716656083
  14. Gaenslen A, Swid I, Liepelt-Scarfone I, Godau J, Berg D. The patients’ perception of prodromal symptoms before the initial diagnosis of Parkinson’s disease. Mov Disord. 2011;26(4):653-658. https://doi.org/10.1002/mds.23499
  15. Chiba Y, Fujishiro H, Iseki E, et al. Retrospective survey of prodromal symptoms in dementia with Lewy bodies: comparison with Alzheimer’s disease. Dement Geriatr Cogn Disord. 2012;33(4):273-281. https://doi.org/10.1159/000339363
  16. Fujishiro H, Iseki E, Nakamura S et al. Dementia with Lewy bodies: early diagnostic challenges. Psychogeriatrics. 2013;13(2):128-138. https://doi.org/10.1111/psyg.12005
  17. Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y, Broe GA, Cummings J, Dickson DW, Gauthier S, Goldman J, Goetz C, Korczyn A, Lees A, Levy R, Litvan I, McKeith I, Olanow W, Poewe W, Quinn N, Sampaio C, Tolosa E, Dubois B. Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord. 2007;22:1689-1707. https://doi.org/10.1002/mds.21507
  18. Irwin DJ, Grossman M, Weintraub D et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol. 2017;16:55-65. https://doi.org/10.1016/S1474-4422(16)30291-5
  19. Rongve A, Soennesyn H, Skogseth R, Oesterhus R, Hortobágyi T, Ballard C, Auestad BH, Aarsland D. Cognitive decline in dementia with Lewy bodies: a 5-year prospective cohort study. BMJ Open. 2016;6(2):010357. https://doi.org/10.1136/bmjopen-2015-010357
  20. Hanyu H, Sato T, Hirao K et al. Differences in clinical course between dementia with Lewy bodies and Alzheimer’s disease. Eur J Neurol. 2009;16(2):212-217. https://doi.org/10.1111/j.1468-1331.2008.02388.x
  21. Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, et al. Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement. 2016. https://doi.org/10.1016/j.jalz.2016.09.015
  22. Howlett DR, Whitfield D, Johnson M, Attems J, O’Brien JT, Aarsland D, Lai MK, Lee JH, Chen C, Ballard C, Hortobágyi T, Francis PT. Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. Brain Pathol. 2015;25(4):401-408. https://doi.org/10.1111/bpa.12182
  23. Ukai K, Matsuo K, Nakamura R, Sobue G, Kosaka K et al. A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt—Jakob disease. Psychogeriatrics. 2010;10:201-205. https://doi.org/10.1111/j.1479-8301.2010.00336.x
  24. Gaig C, Valldeoriola F, Gelpi E et al. Rapidly progressive diffuse Lewy body disease. Mov Disord. 2011;26(7):1316-1323. https://doi.org/10.1002/mds.23506
  25. Walker Z, Possin KL, Boeve BF, Aarsland D. Lewy body dementias. Lancet. 2015;386(10004):1683-1697. https://doi.org/10.1016/S0140-6736(15)00462-6
  26. Boeve BF, Silber MH, Ferman TJ, et al. REM sleep behaviour disorder and degenerative dementia. An association likely reflecting Lewy body disease. Neurology. 1998;51(2):363-370. https://doi.org/10.1212/wnl.51.2.363
  27. Boeve BF. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15-54. https://doi.org/10.1111/j.1749-6632.2009.05115.x
  28. Ferman TJ, Boeve BF, Smith GE et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology. 2011;77:875-882. https://doi.org/10.1212/WNL.0b013e31822c9148
  29. Dugger BN, Boeve BF, Murray ME et al. Rapid eye movement sleep behavior disorder and subtypes in autopsy- confirmed dementia with Lewy bodies. Mov Disord. 2012;27:72-78. https://doi.org/10.1002/mds.24003
  30. Nomura T, Inoue Y, Kaginuma T, Nakashima K. Clinical significance of REM sleep behavior disorder in Parkinson’s disease. Sleep Med. 2013;14:131-135. https://doi.org/10.1016/j.sleep.2012.10.011
  31. Bliwise DL, Trotti LM, Greer SA, Juncos JJ, Rye DB. Phasic muscle activity in sleep and clinical features of Parkinson disease. Ann Neurol. 2010;68:353-359. https://doi.org/10.1002/ana.22076
  32. Postuma RB, Gagnon JF. Symmetry of Parkinson’s disease and REM sleep: one piece of the puzzle. Ann Neurol. 2011;69:905. https://doi.org/10.1002/ana.22259
  33. Postuma RB, Gagnon JF, Vendette M, Montplaisir JY. Markers of neurodegeneration in idiopathic rapid eye movement behavior disorder and Parkinson’s disease. Brain. 2009;132:3298-3307. https://doi.org/10.1093/brain/awp244
  34. Cipolla MJ. The Cerebral Circulation. San Rafael (CA): Morgan & Claypool Life Sciences; 2009.
  35. Bär KJ, Boettger MK, Seidler N, Mentzel HJ, Terborg C, Sauer H. Influence of galantamine on vasomotor reactivity in Alzheimer’s disease and vascular dementia due to cerebral microangiopathy. Stroke. 2007;38(12):3186-3192. https://doi.org/10.1161/STROKEAHA.107.492033
  36. Amiya E, Watanabe M and Komuro I. The Relationship between Vascular Function and the Autonomic Nervous System. Ann Vasc Dis. 2014;7(2):109-119. https://doi.org/10.3400/avd.ra.14-00048
  37. Mazère J, Lamare F, Allard M, Fernandez P and Mayo W. 123-I-iodobenzovesamicol SPECT Imaging of Cholinergic Systems in Dementia with Lewy Bodies. J Nucl Med. 2017;58(1):123-128. https://doi.org/10.2967/jnumed.116.176180
  38. Ferman TJ, Smith GE, Kantarci K, et al. Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies. Neurology. 2013;81(23):2032-2038. https://doi.org/10.1212/01.wnl.0000436942.55281.47
  39. Bombois S, Debette S, Bruandet A, Delbeuck X, Delmaire C, Leys D, Pasquier F. Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients. Stroke. 2008;39:2046-2051. https://doi.org/10.1161/STROKEAHA.107.505206
  40. Troster AI. Neuropsychological characteristics of dementia with Lewy bodies and Parkinson’s disease with dementia: differentiation, early detection, and implications for «mild cognitive impairment» and biomarkers. Neuropsychol Rev. 2008;18(1):103-119. https://doi.org/10.1007/s11065-008-9055-0
  41. Jicha GA, Parisi JE, Dickson DW, Johnson K, Cha R, Ivnik RJ, Tangalos EG, Boeve BF, Knopman DS, Braak H, Petersen RC. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol. 2006;63:674-681. https://doi.org/10.1001/archneur.63.5.674
  42. Fields JA. Ferman TJ, Boeve BF and Smith GE. Neuropsychological assessment of patients with dementing illness. Nat Rev Neurol. 2011;7:677-687. https://doi.org/10.1038/nrneurol.2011.173
  43. Petrova M, Pavlova R, Zhelev Y, Mehrabian S, Raycheva M, Traykov L. Investigation of neuropsychological characteristics of very mild and mild dementia with Lewy bodies. J Clin Exp Neuropsychol. 2016;38(3):354-360. https://doi.org/10.1080/13803395.2015.1117058
  44. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Washington, D.C.: American Psychiatric Association; 2013.
  45. Philippi N, Noblet V, Duron E, Cretin B, Boully C, Wisniewski I et al. Exploring anterograde memory: a volumetric MRI study in patients with mild cognitive impairment. Alzheimers Res Ther. 2016;8(1):26. https://doi.org/10.1186/s13195-016-0190-1
  46. Kemp J, Philippi N, Phillipps C, Demuynck C, Albasser T, Martin-Hunyadi C, Schmidt-Mutter C, Cretin B, Blanc F. Cognitive profile in prodromal dementia with Lewy bodies. Alzheimers Res Ther. 2017;16:9(1):19. https://doi.org/10.1186/s13195-017-0242-1
  47. Heitz C, Noblet V, Phillipps C, Cretin B, Vogt N, Philippi N, et al. Cognitive and affective theory of mind in dementia with Lewy bodies and Alzheimer’s disease. Alzheimers Res Ther. 2016;8(1):10. https://doi.org/10.1186/s13195-016-0179-9
  48. Molano J, Boeve B, Ferman T, Smith G, Parisi J, Dickson D, Knopman D, Graff-Radford N, Geda Y, Lucas J, Kantarci K, Shiung M, Jack C, Silber M, Pankratz VS, Petersen R. Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain. 2010;133:540-556. https://doi.org/10.1093/brain/awp280
  49. Jicha GA, Schmitt FA, Abner E, Nelson PT, Cooper GE, Smith CD, Markesbery WR. Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease. Neurobiol Aging. 2010;31:1805-1813. https://doi.org/10.1016/j.neurobiolaging.2008.09.017
  50. Vardy E, Holt R, Gerhard A, Richardson A, Snowden J, Neary D. History of a suspected delirium is more common in dementia with Lewy bodies than Alzheimer’s disease: a retrospective study. Int J Geriatr Psychiatry. 2014;29:178-181. https://doi.org/10.1002/gps.3986
  51. Ferman TJ, Smith GE, Boeve BF, Ivnik RJ, Petersen RC, Knopman D, Graff-Radford N, Parisi J, Dickson DW. DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology. 2004;27;62(2):181-187.
  52. McKeith IG, Perry RH, Fairburn AF, Jabeen S, Perry EK. Operational criteria for senile dementia of Lewy body type (SDLT). Psychol Med. 1992;22(4):911-922. https://doi.org/10.1017/s0033291700038484
  53. Gore RL, Vardy ERLC, O’Brien JT. Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum? J Neurol Neurosurg Psychiatry. 2015;86(1):50-59. https://doi.org/10.1136/jnnp-2013-306389
  54. Sunwoo MK, Hong JY, Choi J, Park HJ, Kim SH, Lee PH. Alpha-synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy. Neurology. 2013;80(9):810-813. https://doi.org/10.1212/WNL.0b013e3182840782
  55. Ballard C, Holmes C, McKeith I et al. Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer’s disease. Am J Psychiatry. 1999;156:1039-1045. https://doi.org/10.1176/ajp.156.7.1039
  56. Poewe W, Wenning GK. Atypical parkinsonism. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C, eds. Neurological Disorders: Course and Treatment. San Diego, IL: Academic Press, 2003;1081-1098.
  57. Colloby SJ, Vasudev A, O’Brien JT, Firbank MJ, Parry SW, Thomas AJ. Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression. Br J Psychiatry. 2011;199(5):404-410. https://doi.org/10.1192/bjp.bp.110.090423
  58. Barber R, Scheltens P, Gholkar A, Ballard C, McKeith I, Ince P, Perry R, O’Brien J. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging. J Neurol Neurosurg Psychiatry. 1999;67(1):66-72. https://doi.org/10.1136/jnnp.67.1.66
  59. Auning E, Rongve A, Fladby T, Booij J, Hortobagyi T, Siepel FJ, Ballard C, Aarsland D. Early and presenting symptoms of dementia with lewy bodies. Dement Geriatr Cogn Disord. 2011;32:202-208. https://doi.org/10.1159/000333072
  60. Chiba Y, Fujishiro H, Iseki E, Ota K, Kasanuki K, Hirayasu Y, Satoa K. Retrospective survey of prodromal symptoms in dementia with Lewy bodies: comparison with Alzheimer’s disease. Dement Geriatr Cogn Disord. 2012;33:273-281. https://doi.org/10.1159/000339363
  61. Nedelska Z, Ferman TJ, Boeve BF, et al. Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging. 2015;36(1):452-461. https://doi.org/10.1016/j.neurobiolaging.2014.07.005
  62. Blanc F, Colloby SJ, Cretin B, de Sousa PL, Demuynck C, O’Brien JT, Martin-Hunyadi C, McKeith I, Philippi N, Taylor JP. Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease. Alzheimers Res Ther. 2016;8:31. https://doi.org/10.1186/s13195-016-0198-6
  63. Blanc F, Colloby SJ, Philippi N, de Pétigny X, Jung B, Demuynck C, Phillipps C, Anthony P, Thomas A, Bing F, Lamy J, Martin-Hunyadi C, O’Brien JT, Cretin B, McKeith I, Armspach JP, Taylor JP. Cortical Thickness in Dementia with Lewy Bodies and Alzheimer’s Disease: A Comparison of Prodromal and Dementia Stages. PLoS One. 2015;10(6):0127396. https://doi.org/10.1371/journal.pone.0127396
  64. Sarro L, Senjem ML, Lundt ES, Przybelski SA, Lesnick TG, Graff-Radford J, Boeve BF, Lowe VJ, Ferman TJ, Knopman DS, Comi G, Filippi M, Petersen RC, Jack CR Jr, Kantarci K. Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies. Brain. 2016;139(10):2740-2750. https://doi.org/10.1093/brain/aww193
  65. Fukui T, Oowan Y, Yamazaki T, Kinno R. Prevalence and clinical implication of microbleeds in dementia with lewy bodies in comparison with microbleeds in Alzheimer’s disease. Dement Geriatr Cogn Dis Extra. 2013;3(1):148-160. https://doi.org/10.1159/000351423
  66. Ghebremedhin E, Rosenberger A, Rub U, Vuksic M, Berhe T, Bickeboller H et al. Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with Lewy body diseases. J Neuropathol Exp Neurol. 2010;69:442-448. https://doi.org/10.1097/NEN.0b013e3181d88e63
  67. Jellinger KA. Formation and development of Lewy pathology: a critical update. J Neurol. 2009;256(3):270-279. https://doi.org/10.1007/s00415-009-5243-y
  68. Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H et al. Diagnostic accuracy of 123-I-meta-iodobenzylguanidine myocardial scintigraphy in dementia with Lewy bodies: a multicenter study. PLoS One. 2015;10(3):0120540. https://doi.org/10.1371/journal.pone.0120540
  69. Gjerløff T, Fedorova T, Knudsen K, Munk OL, Nahimi A et al. Imaging acetylcholinesterase density in peripheral organs in Parkinson’s disease with 11C-donepezil PET. Brain. 2015;138(3):653-663. https://doi.org/10.1093/brain/awu369
  70. Kobayashi S, Makino K, Hatakeyama S et al. The usefulness of combined brain perfusion single-photon emission computed tomography, Dopamine-transporter single-photon emission computed tomography, and 123-I-metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies. 2017. https://doi.org/10.1111/psyg.12227
  71. Fujishiro H, Iseki E, Kasanuki K, Chiba Y, Ota K, Murayama N, Sato K. A follow up study of non-demented patients with primary visual cortical hypometabolism: prodromal dementia with Lewy bodies. J Neurol Sci. 2013;334(1-2):48-54. https://doi.org/10.1016/j.jns.2013.07.013
  72. Miners S, Moulding H, de Silva R, Love S. Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies. Brain Pathol. 2014;24(4):334-343. https://doi.org/10.1111/bpa.12130
  73. Sakakibara R, Ogata T, Haruta M et al. Amnestic mild cognitive impairment with low myocardial metaiodobenzylguanidine uptake. Am J Neurodegener Dis. 2012;1:146-151.
  74. McKeith I, O’Brien J, Walker Z et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007;6:305-313. https://doi.org/10.1016/S1474-4422(07)70057-1
  75. Siepel FJ, Rongve A, Buter TC et al. (123I)FP-CIT SPECT in suspected dementia with Lewy bodies: a longitudinal case study. BMJ Open. 2013;3(4):002642. https://doi.org/10.1136/bmjopen-2013-002642
  76. Thomas AJ, Attems J, Colloby SJ, O’Brien JT, McKeith I, et al. Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB. Neurology. 2017;88(3):276-283. https://doi.org/10.1212/WNL.0000000000003512
  77. Kasuga K, Nishizawa M, Ikeuchi T. alpha-Synuclein as CSF and blood biomarker of dementia with Lewy bodies. Int J Alzheimers Dis. 2012;437025. https://doi.org/10.1155/2012/437025
  78. Bousiges O, Cretin B, Lavaux T, Philippi N, Jung B, Hezard S, Heitz C, Demuynck C, Gabel A, Martin-Hunyadi C, Blanc F. Diagnostic Value of Cerebrospinal Fluid Biomarkers (Phospho-Tau181, total-Tau, Aβ42, and Aβ40) in Prodromal Stage of Alzheimer’s Disease and Dementia with Lewy Bodies. J Alzheimers Dis. 2016;51(4):1069-1083. https://doi.org/10.3233/JAD-150731
  79. Swirski M, Miners JS, de Silva R, Lashley T, Ling H, Holton J, Revesz T, Love S. Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson’s disease. Alzheimers Res Ther. 2014;6(5-8):77. https://doi.org/10.1186/s13195-014-0077-y
  80. Morimoto S, Takao M, Hatsuta H, Nishina Y, Komiya T, Sengoku R, Nakano Y, Uchino A, Sumikura H, Saito Y, Kanemaru K, Murayama S. Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer’s disease: An autopsy-confirmed study. PLoS One. 2017:12(2):0171524. https://doi.org/10.1371/journal.pone.0171524

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