The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Korotkov A.G.

Razumovskiy Saratov State Medical University, Saratov, Russia

Muzalevskaia D.S.

Razumovskiy Saratov State Medical University, Saratov, Russia

Kolokolov O.V.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. V.I. Razumovskogo Minzdravsotsrazvitiia Rossii

A role of antioxidants in the complex treatment of epilepsy

Authors:

Korotkov A.G., Muzalevskaia D.S., Kolokolov O.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2): 44‑48

DOI: 10.17116/jnevro20161169244-48

Read: 15109 times

Contact the author
Table of contents

A ROLE OF ANTIOXIDANTS IN THE COMPLEX TREATMENT OF EPILEPSY
A ROLE OF ANTIOXIDANTS IN THE COMPLEX TREATMENT OF EPILEPSY

To cite this article:

Korotkov AG, Muzalevskaia DS, Kolokolov OV. A role of antioxidants in the complex treatment of epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9‑2):44‑48. (In Russ.)
https://doi.org/10.17116/jnevro20161169244-48

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Epileptogenesis and risk factors of symptomatic epileptic seizures in patients with acute cere­brovascular acci­dents. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):26-31
Resu­lts of the inte­rnational multicenter randomized, double-blind, placebo-controlled clinical trial for the evaluation of the effi­cacy and safety of the sequential therapy with ethy­lmethylhydroxypyridine succinate in patients in the acute and early reco­very periods of ischemic stroke (MIR). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):40-53
The impact of Mexi­dol on improving quality of life para­meters and functional kidney status as part of complex therapy for cognitive impairments in como­rbid patients with microalbuminuria against the background of arte­rial hype­rtension and type 2 diabetes mellitus. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(4):478-478
Febrile infe­ction-related epilepsy syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):34-40
The pote­ntial of cortical electrical stimulation for the study of auto­nomic dysfunction in patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):25-34
The role of neuroinflammation in the deve­lopment of seizure acti­vity and auto­nomic diso­rders in patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):50-58
The possibilities of antioxidant neuroretinoprotection in the treatment of primary open-angle glaucoma. Russian Annals of Ophthalmology. 2025;(4):49-59
Therapies for focal epilepsy asso­ciated with brain tumors. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):14-20
The rela­tionship between the inte­rictal para­meters of cardiovascular auto­nomic regu­lation and the outcomes of surgical treatment of epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):50-59
Oxidative stress and depression in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):131-138
Abstract:

The article covers the pathogenesis of epilepsy and goals of modern pharmacotherapy. The features of the development of epilepsy of vascular origin are presented as well. The authors describe the ways to increase the efficacy and decrease side-effects of anticonvulsants (a combination with antioxidant and antihypoxant drugs that was confirmed by the data on an important role of free-radical processes in the pathogenesis of epilepsy). Mechanisms of action and efficacy of antioxidant treatment (on the example of 2-ethyl-6-methyl-3-hydroxypyridine succinate - mexidol) in the complex treatment of various forms of epilepsy are analyzed. The main advantages of mexidol as an add-on drug in the treatment of various types of epileptic syndrome in adults, taking into account its neuroprotective and antihypoxant action, are considered. Literature results have shown the positive effect of mexidol on the course of disease and its safety in the treatment of epilepsy.

Keywords:

epilepsy
antiepileptic drugs
antioxidants
ethylmethilhydroxypiridine succinate
mexidol

Authors:

Korotkov A.G.

Razumovskiy Saratov State Medical University, Saratov, Russia

Muzalevskaia D.S.

Razumovskiy Saratov State Medical University, Saratov, Russia

Kolokolov O.V.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. V.I. Razumovskogo Minzdravsotsrazvitiia Rossii

Close metadata

References:

  1. Dzayk LA, Zenkov, Kirichenko AG, Epilepsy. Kiev; 2001.
  2. Zavalishin IA, Zakharova MN. Astroglia: functional aspects. Neuroimmunology. SPb.; 1996.
  3. O'Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS. Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy. Neurology. 2011;76(1):34-40. doi: 10.1212/WNL.0b013e318203e93d
  4. Karlov VA. Epilepsy in children and adult women and men: a manual for physicians. M.: Meditsina; 2010.
  5. Sazgar M, Bourgeois BF. Аggravation of epilepsy by antiepileptic drugs. Journal Pediatric Neurology. 2005;33(4):227-234. doi.org/10.1016/j.pediatrneurol.2005.03.001
  6. Avakian GN. Materials of international conference «Epilepsy: medical and social aspects, diagnosis and treatment». M. 2005;46-54.
  7. Penfield W, Erickson T. Epilepsy and cerebral localization. M. 1949.
  8. Jokeit H, Ebner A. The risk of cognitive decline in patient with refractory temporal lobe epilepsy. Cambridge; 2002. doi.org/10.1017/CBO9780511544354.011
  9. Avakian G.G. Clinical and neurophysiological study of combinations of new forms of anticonvulsants and antioxidants in patients with epilepsy with secondary generalized seizures»: author's abstract of dissertation on competition of a scientific degree of candidate of medical Sciences. M. 2011. Active on 28.07.16. Available at: http://www.dissercat.com/content/kliniko-neirofiziologicheskoe-izuchenie-kombinatsii-novykh-form-antikonvulsantov-i-antioksid
  10. Avakian GG, Nerobkova LN, Oleynikova, OM, Voronina TA, Avakyan GN, Gusev EI. Application valproat and antioxidant in case of secondary generalized seizures. Epilepsy and paroxysmal States. 2011;3(2):34-44.
  11. Litvinovich EF. Clinical and pharmacoeconomic effectiveness of antioxidant Mexidol in the combined pathogenetic therapy of patients with symptomatic focal epilepsy. Bulletin of experimental biology and medicine. 2006;(suppl 1):45-47.
  12. Korotkov AG. the use of the drug «Mexidol in complex treatment of patients with pharmacoresistant partial epilepsy. Bulletin of experimental biology and medicine. 2006;(suppl 1):34-36.
  13. Odinak MM, Dyskin DE. Epilepsy: etiology, clinic, differential diagnostics, medical treatment. SPb.: Polytechnic; 1997.
  14. Forsgren L, Bucht G, Eriksson S et al. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population based study. Epilepsia. 1996;37:224-229. doi: 10.1111/j.1528-1157.1996.tb00017.x
  15. Hauser WA, Kurland LT. The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967. Epilepsia. 1975;16:61-66. doi: 10.1111/j.1528-1157.1975.tb04721.x
  16. Danilova TV, Khasanova DR, Kamalov IR. post-stroke epilepsy: predatory, risk factors, clinical variants, treatment. Journal of Neurology, neuropsychiatry, psychosomatics. 2012;1:82-87. doi.org/10.14412/2074-2711-2012-367
  17. Kalinin VV, Zheleznova EV, Sokolova LV. et al. Mental disorders in epilepsy. Manual for doctors. M.: Print city; 2006.
  18. Kalinin VV. the Psychiatric issues of epilepsy and psychiatry. Social and wedge psychiatrist. 2003;3:5-11.
  19. Trimble M, Schmitz B. Seizures, Affective Disorders and Anticonvulsant Drugs. Clarus Press Ltd, Guildford, UK; 2002.
  20. Novikov VE, Maslova NN. The effect of Mexidol on the course of post-traumatic epilepsy. Experimental and clinical pharmacology. 2003;66(4):9-11.
  21. Avakian GN, Voronina TA, Garibova TL, etc., 2nd East-European conference «Epilepsy and clinical neurophysiology». Zaporozhye; 2010;260-261.
  22. Badalyan OL, Avakyan GN, Voronina TA, Nerobkova LN. The possibility of using the combination of carbamazepine and Mexidol in adolescents with partial epilepsy 2nd Eastern European conference «Epilepsy and clinical neurophysiology». Zaporozhye; 2010;189-190.
  23. Loshakov VA, Youssef ES, Likhterman LB. et al. Diagnosis and surgical treatment of post-traumatic hydrocephalus. Journal Questions neurosurgery them. N.N. Burdenko. 1993;3:18-22
  24. Savenkov AA, Badalyan OL, Avakyan GN. Application of nootropics and antioxidants in the complex therapy of symptomatic posttraumatic epilepsy. Journal of Neurology and Psychiatry. 2013;6:26-34.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.