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Shamakina I.Yu.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Proskuryakova T.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Shokhonova V.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Ulyanova E.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Anokhin P.K.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Tapabarko I.E.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Anokhina I.P.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

An effect of cabergoline on alcohol consumption and DRD2 expression in the brain of rats with chronic alcohol intoxication

Authors:

Shamakina I.Yu., Proskuryakova T.V., Shokhonova V.A., Ulyanova E.V., Anokhin P.K., Tapabarko I.E., Anokhina I.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11‑2): 74‑80

DOI: 10.17116/jnevro201611611274-80

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Table of contents

AN EFFECT OF CABERGOLINE ON ALCOHOL CONSUMPTION AND DRD2 EXPRESSION IN THE BRAIN OF RATS WITH CHRONIC ALCOHOL INTOXICATION
AN EFFECT OF CABERGOLINE ON ALCOHOL CONSUMPTION AND DRD2 EXPRESSION IN THE BRAIN OF RATS WITH CHRONIC ALCOHOL INTOXICATION

To cite this article:

Shamakina IYu, Proskuryakova TV, Shokhonova VA, Ulyanova EV, Anokhin PK, Tapabarko IE, Anokhina IP. An effect of cabergoline on alcohol consumption and DRD2 expression in the brain of rats with chronic alcohol intoxication. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11‑2):74‑80. (In Russ.)
https://doi.org/10.17116/jnevro201611611274-80

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Objective. Cabergoline is a high selective agonist of dopamine D2 receptors (D2R). The activation of D2R plays an important role in the regulation of dopamine transmission, the imbalance of which is thought to underlie the development of alcohol motivation. To examine this possibility, cabergoline effects on alcohol consumption and brain DRD2 expression in rats with chronic alcohol intoxication were studied. Material and methods. Male Wister rats were studied using the following methods: modelling of chronic alcohol intoxication, testing in «10% alcohol vs water» choice regimen, quantitative RT-PCR. Results. Systemic administration of 0.5 mg/kg of cabergoline significantly decreases alcohol intake in alcohol-preferring rats. At the same time, cabergoline elevates the DRD2 expression in the midbrain and striatum of high-alcohol-preferring rats but not in intact (alcohol-naïve) animals. Conclusion. The involvement of cabergoline in the DRD2 expression may lead to the decrease in alcohol motivation. These findings indicate that cabergoline needs further investigations as a new potential medication for alcohol use disorder.

Keywords:

alcohol
dopamine receptors agonists
cabergoline
gene expression
real-time RT-PCR

Authors:

Shamakina I.Yu.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Proskuryakova T.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Shokhonova V.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Ulyanova E.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Anokhin P.K.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Tapabarko I.E.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

Anokhina I.P.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

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