The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Yakovlev A.N.

Lipetsk Regional Narcological Dispensary, Lipetsk, Russia

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Schurina A.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Romashkin R.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

The forecast of illicit drug use in adolescents with addictive behavior: personality traits and the level of genetic risk of substance dependence

Authors:

Yakovlev A.N., Brodianskiĭ V.M., Schurina A.V., Romashkin R.A., Kibitov A.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11‑2): 9‑12

DOI: 10.17116/jnevro20161161129-12

Read: 1824 times

Contact the author
Table of contents

THE FORECAST OF ILLICIT DRUG USE IN ADOLESCENTS WITH ADDICTIVE BEHAVIOR: PERSONALITY TRAITS AND THE LEVEL OF GENETIC RISK OF SUBSTANCE DEPENDENCE.
THE FORECAST OF ILLICIT DRUG USE IN ADOLESCENTS WITH ADDICTIVE BEHAVIOR: PERSONALITY TRAITS AND THE LEVEL OF GENETIC RISK OF SUBSTANCE DEPENDENCE.

To cite this article:

Yakovlev AN, Brodianskiĭ VM, Schurina AV, Romashkin RA, Kibitov AO. The forecast of illicit drug use in adolescents with addictive behavior: personality traits and the level of genetic risk of substance dependence. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11‑2):9‑12. (In Russ.)
https://doi.org/10.17116/jnevro20161161129-12

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The expe­rience of the narcological service medi­cal specialists in the prevention of substance use among adolescents and youth. Russian Journal of Preventive Medi­cine. 2025;(5):62-68
Impact of alco­hol consumption on nature of nutrition, meta­bolism and human target organs. Part 3. The role and significance of micronutrients. Russian Journal of Preventive Medi­cine. 2025;(5):117-123
Consumption of alco­holic beve­rages by different gene­rations of the Russian Fede­ration popu­lation. Russian Journal of Preventive Medi­cine. 2025;(6):11-20
Recu­rrent pain syndromes in adolescents of different ages. Russian Journal of Pain. 2025;(2):24-31
Health lite­racy among schoolchildren in Repu­blic of Kaza­khstan: socio-demographic differences and asso­ciations with beha­vioral risk factors. Russian Journal of Preventive Medi­cine. 2025;(8):70-77
Chro­nic traumatic ence­phalopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):16-24
Suicidal beha­vior in adolescents. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):35-42
Diagnosis and treatment of cluster headache: a differentiated clinical and gene­tic approach. Russian Journal of Pain. 2025;(3):11-16
Influence of age and sex on values of SNOT-22 sino­nasal test domains in children and adolescents with bronchial asthma. Russian Rhinology. 2025;(3):197-204
Cardiovascular indi­cators in modern schoolchildren of the Novo­sibirsk city: retrospective asse­ssment. Russian Journal of Preventive Medi­cine. 2025;(9):70-77
Abstract:

Objective. To clarify the psychological mechanism underlying the genetic risk of substance addiction at the first stage of drug use by adolescents. Material and methods. Genetic risk was evaluated by genotyping of 5 polymorphisms of the dopaminergic system genes (dopamine receptor D2 and D4 genes and tyrosine hydroxylase gene). Psychological testing was performed using the Russian version of Temperament and Character Inventory (TCI-125). Seventy-five adolescents, aged 14—17 years, (girls 32%), who misused alcohol, including 22 adolescents using drugs, were examined. Results and conclusion. The level of genetic risk was directly correlated with the probability of drug use by boys, for girls the correlation was not confirmed. The increase of the level of genetic risk for boys was correlated with the increase on the scale «Self-directedness» of TCI-125 that may reflect a probable tendency to replacement of negative information, feeling of illusory wellbeing. The findings clarify the direction of measures for the prevention of drug use.

Keywords:

addiction
alcohol
drugs
adolescents
genetics
heredity
genetic risk
gene polymorphism
dopamine
personality
TCI-125

Authors:

Yakovlev A.N.

Lipetsk Regional Narcological Dispensary, Lipetsk, Russia

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Schurina A.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Romashkin R.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Close metadata

References:

  1. Kibitov AO. Clinical genetics of substance abuse: the role of dopamine system genes. Voprosy narkologii. 2013;6:60-80. (In Russ.).
  2. Barsky VI, Aksenova М, Kozlova OB, Kirillov AV, Demin AA, Ilyinykh LI, Rappoport K, Asanov А. An association study of polymorphisms of the genes involved in the dopaminergic (DRD2/ANKK1) and serotonergic (HTR2A) brain systems with personality characteristics of adolescents. Russian Journal of Genetics: Applied Research. 2011;1(5):416-423. doi:10.1134/S2079059711050030
  3. Hiroi N, Agatsuma S. Genetic susceptibility to substance dependence. Molecular Psychiatry. 2005;10:336-344. doi:10.1038/sj.mp.4001622
  4. Tsuchimine S, Yasui-Furukori N, Sasaki K, Kaneda A, Sugawara N, Yoshida S, Kaneko S. Association between the dopamine D2 receptor (DRD2) polymorphism and the personality traits of healthy Japanese participants. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2012;38(2):190-193. doi:10.1016/j.pnpbp.2012.03.008
  5. Gagarinova ES, Zubareva OE. Novelty search as factor of prediction of drugs consumption. Narkologiya. 2010;2:86-90. (In Russ.).
  6. Hansenne M, Pinto E, Pitchot W et al. Further evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study. Personality and Individual Differences. 2002;33:967-977. doi:10.1016/S0191-8869(01)00205-7
  7. Lusher JM, Chandler C, Ball D. Dopamine D4 receptor gene (DRD4) is associated with novelty seeking (NS) and substance abuse: the saga continues. Mol Psychiatry. 2001;6:497-499. doi:10.1038/sj.mp.4000918
  8. Casey BJ, Duhoux S, Cohen MM. Adolescence: What do Transmission, Transition, and Translation have to do with it? Neuron. 2010;67(5):749-760. doi:10.1016/j.neuron.2010.08.033
  9. Vormfelde SV, Hoell I, Tzvetkov M, Jamrozinski K, Sehrt D, Brockmöller J, Leibing E. Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms. Journal of Psychiatric Research. 2006;40(6):568-576. doi:10.1016/j.jpsychires.2005.10.002
  10. Anokhina IP. Main biological mechanisms of psychoactive substance addiction. Voprosy narkologii. 2013;6:40-59. (In Russ.).
  11. Cloninger CR, Przybeck T, Svrakic DM, Wetzel R. Temperament and Character Inventory (TCI). St-Louis: American Psychological Association; 1994. doi:10.1037/t03902-000
  12. Pyatnitskaya IN, Naidenova NG. Podrostkovaya narkologiya. M.: Meditsina; 2008. (In Russ.).
  13. Taylor SE, Kemeny ME, Reed GM, Bower JE, Gruenewald TL. Psychological resources, positive illusions, and health. American Psychologist. 2000;55(1):99-109. doi:10.1037//0003-066x.55.1.99
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.