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Yakovlev A.N.

Lipetsk Regional Narcological Dispensary, Lipetsk, Russia

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Schurina A.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Romashkin R.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

The forecast of illicit drug use in adolescents with addictive behavior: personality traits and the level of genetic risk of substance dependence.

Authors:

Yakovlev A.N., Brodianskiĭ V.M., Schurina A.V., Romashkin R.A., Kibitov A.O.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11‑2): 9‑12

DOI: 10.17116/jnevro20161161129-12

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Table of contents

THE FORECAST OF ILLICIT DRUG USE IN ADOLESCENTS WITH ADDICTIVE BEHAVIOR: PERSONALITY TRAITS AND THE LEVEL OF GENETIC RISK OF SUBSTANCE DEPENDENCE.
THE FORECAST OF ILLICIT DRUG USE IN ADOLESCENTS WITH ADDICTIVE BEHAVIOR: PERSONALITY TRAITS AND THE LEVEL OF GENETIC RISK OF SUBSTANCE DEPENDENCE.

To cite this article:

Yakovlev AN, Brodianskiĭ VM, Schurina AV, Romashkin RA, Kibitov AO. The forecast of illicit drug use in adolescents with addictive behavior: personality traits and the level of genetic risk of substance dependence.. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11‑2):9‑12. (In Russ.)
https://doi.org/10.17116/jnevro20161161129-12

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
 
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Objective. To clarify the psychological mechanism underlying the genetic risk of substance addiction at the first stage of drug use by adolescents. Material and methods. Genetic risk was evaluated by genotyping of 5 polymorphisms of the dopaminergic system genes (dopamine receptor D2 and D4 genes and tyrosine hydroxylase gene). Psychological testing was performed using the Russian version of Temperament and Character Inventory (TCI-125). Seventy-five adolescents, aged 14—17 years, (girls 32%), who misused alcohol, including 22 adolescents using drugs, were examined. Results and conclusion. The level of genetic risk was directly correlated with the probability of drug use by boys, for girls the correlation was not confirmed. The increase of the level of genetic risk for boys was correlated with the increase on the scale «Self-directedness» of TCI-125 that may reflect a probable tendency to replacement of negative information, feeling of illusory wellbeing. The findings clarify the direction of measures for the prevention of drug use.

Keywords:

addiction
alcohol
drugs
adolescents
genetics
heredity
genetic risk
gene polymorphism
dopamine
personality
TCI-125

Authors:

Yakovlev A.N.

Lipetsk Regional Narcological Dispensary, Lipetsk, Russia

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Schurina A.V.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Romashkin R.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

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