Objective — to establish prognostic factors of recurrent acute cerebrovascular complications after ischemic stroke. Material and methods. A prospective observational study on the 21—22nd day of the acute stage of ischemic stroke included 148 patients, aged 60 [5; 68] years. Following the discharge, a unified telephone survey of patients or their relatives was performed every 3 months. Recurrent strokes, including those with fatal outcome, and transient ischemic attacks (TIA) were recorded. Results and conclusion. The long-term prospective follow-up duration was 35 [28; 40] months. In 26 (18%) patients, 31 cerebral complications, including 24 recurrent ischemic strokes, 6 TIA, 1 hypertensive intracerebral hemorrhage were registered. Recurrent cerebral complications found to be associated with age older 67 years, ischemic heart disease, multiple focal brain lesions, supraventricular arrhythmias more 46/day, bradyarrhythmias, ventricular arrhythmias. The use of thiazide and thiazide-liked diuretics as part of antihypertensive therapy was associated with a reduced risk of cerebral complications.