Objectives. Authors studied the levels of pro- (IL-1, TNF-, IL-6, IL-8, IFN-) and anti-inflammatory cytokines (IL-1Ra, IL-10, IL-4) in the blood serum at 1st and 2nd day of acute period of ischemic stroke with hemorrhagic transformation (IS HT). Material and methods. We compared cytokines levels in the blood serum of patients with IS HT and in patients with ischemic (IS) and hemorrhagic stroke (HT). Results. In patients with IS HT, significantly lower levels of IL-1, TNO- and higher levels of IL-6 were noted at 1st and 2nd day compared to patients with IS and HS. Significantly lower levels of IFN- and IL-10 with increased levels of IL-4 were noted at 1st and 2nd day of IS HT compared to IS. There were no differences in concentrations of IFN-, IL-10 and IL-4 between IS HT and HS groups. Conclusion. Cytokines are not only involved in the development of HT in IS but can be predictors of HT.