Cognitive disorders in multiple sclerosis: correlations between neuropsychological, neurophysiological and neuroimaging characteristics

Alifirova V.M.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk, Russia

SPIN RSCI: 3824-1016
Scopus AuthorID: 6507431329
ORCID: 0000-0002-4140-3223

Musina N.F.

Kafedra nevrologii i neĭrokhirurgii Sibirskogo gosudarstvennogo meditsinskogo universiteta, Tomsk

Cognitive disorders in multiple sclerosis: correlations between neuropsychological, neurophysiological and neuroimaging characteristics

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Alifirova V.M., Musina N.F.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(2‑2): 57‑60

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To cite this article:

Alifirova VM, Musina NF. Cognitive disorders in multiple sclerosis: correlations between neuropsychological, neurophysiological and neuroimaging characteristics. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(2‑2):57‑60. (In Russ.)

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Multiple sclerosis (MS) is an autoimmune disease of CNS characterized by myelin destruction and axonal damage. An aim of the study was to analyze the results of neuropsychological tests, cognitive evoked potentials P300 and to evaluate a role of brain atrophy in MS. Neurocognitive functions have been studied in 109 patients with MS. To study cognitive functions, we used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya, cognitive evoked potentials P300. Magnetic resonance imaging data were analyzed in 71 patients. Correlations between cognitive functions, the activity of the disease and the expression of brain atrophy were found.

Keywords:

multiple sclerosis

cognitive disorders

neuropsychological studies

cognitive evoked potentials P300

cerebral atrophy