The objective of this study was the comprehensive assessment of the association between the level of hormones, reproductive disorders, symptoms of epilepsy and psychopathological symptoms in female patients with epilepsy and affective disorders. We studied 101 women using clinical and psychopathological examination, hormone measurement and statistical analysis. The data analysis showed correlations between scores on the scales measuring the mental health status and the level of hormones in the blood of patients. It has been concluded that the effect of female sex hormones on affective symptoms depends on characteristics of depressive affect.