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Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Shetova I.M.

Ministry of Health of the Russian Federation, Moscow, Russia

Efremova N.M.

Kafedra fundamental'noĭ i klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, gorodskaia klinicheskaia bol'nitsa #31, Moskva

Anisimov K.V.

Nauchno-issledovatel'skiĭ institut tserebrovaskuliarnoĭ patologii i insul'ta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Efficacy and safety of the combined therapy with citicholine and actovegin in the acute period of ischemic stroke

Authors:

Shamalov N.A., Stakhovskaya L.V., Shetova I.M., Efremova N.M., Anisimov K.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9‑2): 13‑17

Read: 9154 times

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EFFICACY AND SAFETY OF THE COMBINED THERAPY WITH CITICHOLINE AND ACTOVEGIN IN THE ACUTE PERIOD OF ISCHEMIC STROKE
EFFICACY AND SAFETY OF THE COMBINED THERAPY WITH CITICHOLINE AND ACTOVEGIN IN THE ACUTE PERIOD OF ISCHEMIC STROKE

To cite this article:

Shamalov NA, Stakhovskaya LV, Shetova IM, Efremova NM, Anisimov KV. Efficacy and safety of the combined therapy with citicholine and actovegin in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(9‑2):13‑17. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

One hundred and four patients with acute carotid ischemic stroke were included in the study. Patients were divided into 4 groups. Patients of control group (group 1) were treated with equal basic and reperfusional therapy without any cytoprotectors. Patients of the 2nd group received citicholine in dose 1000 mg per day. Patients of the 3rd group were treated with 250 ml actovegin per day. The NIH stroke scale, the modified Rankin scale and the Barthel index were used to assess neurological status dynamics. The significant decrease of neurological deficit and improvement of functional recovery were seen in patients treated both with citicholine and actovegin (p<0,005) to the 30th day compared to the control group. There was a trend towards the decrease of brain infarction volume within 5 days after stroke in patients of the 4th group. No side-effects of citicholine and actovegin were found.

Keywords:

ischemic stroke
cytoprotection
citicholine
actovegin

Authors:

Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Shetova I.M.

Ministry of Health of the Russian Federation, Moscow, Russia

Efremova N.M.

Kafedra fundamental'noĭ i klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, gorodskaia klinicheskaia bol'nitsa #31, Moskva

Anisimov K.V.

Nauchno-issledovatel'skiĭ institut tserebrovaskuliarnoĭ patologii i insul'ta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

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References:

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