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Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Brusov O.S.

Scientific center of mental health, Moscow, Russia

Faktor M.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Zlobina G.P.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lavrushina O.M.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Petrova E.A.

FGBU "NII onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Savina M.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients

Authors:

Golimbet V.E., Brusov O.S., Faktor M.I., Zlobina G.P., Lezheĭko T.V., Lavrushina O.M., Petrova E.A., Savina M.A., Skvortsova V.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4‑2): 42‑45

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To cite this article:

Golimbet VE, Brusov OS, Faktor MI, et al. . Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4‑2):42‑45. (In Russ.)

 
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Platelet serotonin content in patients in the acute period of stroke is an important index of clinical changes during the post stroke period as well as a predictor of development of mental disorders. We studied the association between two polymorphisms (5-HTTLPR and Val66Met BDNF) and the platelet serotonin content in 47 patients with stroke. We also investigated the moderating effect of genetic variants on the association between platelet serotonin content and development of affective and anxiety disorders in stroke patients in the acute period of stroke. The interaction effect of two polymorphisms on levels of platelet serotonin was found. The lowest level was observed in patients with the diplotype LL*ValVal, the highest level - in the group of patients with the LL genotype and genotypes containing at least one copy of a Met allele. No moderating effect of genetic variants on the relationship between serotonin content and affective or anxiety disorder was found.

Keywords:

stroke
serotonin
gene
serotonin transporter
depression
generalized anxiety disorder
brain neurotrophic factor

Authors:

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Brusov O.S.

Scientific center of mental health, Moscow, Russia

Faktor M.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Zlobina G.P.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Lavrushina O.M.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Petrova E.A.

FGBU "NII onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Savina M.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

List of references:

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  3. Juhasz G., Zsombok T., Laszik A. et al. Despite the general correlation of the serotonin transporter gene regulatory region polymorphism (5-HTTLPR) and platelet serotonin concentration, lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants. Neurosci Lett 2003; 350: 1: 56-60.
  4. Lesch K.P., Mossner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiat 1998; 44; 179-192.
  5. Ishizaki F. A follow-up study of platelet-rich plasma serotonin in clinical subtypes of cerebral infarction. J Neural Transm 1987; 69: 1-2: 123-129.
  6. Ban Y., Watanabe T., Miyazaki A. et al. Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementia. Atherosclerosis 2007; 195: 1: 153-159.
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  8. Petrova E.A., Savina M.A., Aleksandrova N.V. i dr. Patogeneticheskie osobennosti razvitiya postinsul'tnykh affektivnykh rasstroistv. Materialy I Mezhdunarodnogo kongressa «Neiroreabilitatsiya-2009». M 2009; 38.
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  11. Brusov O.S., Kaleda V.G., Kolyaskina G.I. i dr. Tsitomegalovirusnaya infektsiya kak faktor formirovaniya rezistentnosti k lecheniyu neiroleptikami bol'nykh s pervym pristupom endogennogo psikhoza yunosheskogo vozrasta. Psikhiatriya 2007; 28: 4: 62-71.
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