The objective of the present work was to study characteristics of mild neuro-orthopedic pathology in the children and adolescents with special reference to its etiological, pathophysiological and clinical features and to develop the program for the differentiated treatment of this condition. Material and methods. We have examined 100 children at the age from 3 to 15 years presenting with minor asymmetry of the lower extremity length, primary (idiopathic) pelvic obliquity, and pathology of the locomotor system of the known etiology (secondary). We have conducted topographical and electromyographic studies. In addition, the autonomic dysfunction has been evaluated. Results. Mild neuro-orthopedic pathology develops in the process of the child’s growth and development in association with the neuromuscular and autonomic disorders. The targeted conservative treatment in combination with the adequate clinical supervision may prevent the further progression of pathology in question.