The clinical results and lipid peroxidation dynamics in the patients presenting with psoriasis treated by the applications of a natural highly mineralized bromine-iodine brine

El'kin V.D.; Koriukina I.P.; Datskovskiĭ Ia.S.; Plotnikova E.V.

doi:https://doi.org/

El'kin V.D.

E.A. Vagner Perm State Medical Academy

Koriukina I.P.

GBOU VPO "Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.V. Vagnera" Minzdrava Rossii

Datskovskiĭ Ia.S.

GBOU VPO "Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera" Minzdrava Rossii

Plotnikova E.V.

E.A. Vagner Perm State Medical Academy

The clinical results and lipid peroxidation dynamics in the patients presenting with psoriasis treated by the applications of a natural highly mineralized bromine-iodine brine

Authors:

El'kin V.D., Koriukina I.P., Datskovskiĭ Ia.S., Plotnikova E.V.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2014;91(2): 38‑42

Read: 1108 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

El'kin VD, Koriukina IP, Datskovskiĭ IaS, Plotnikova EV. The clinical results and lipid peroxidation dynamics in the patients presenting with psoriasis treated by the applications of a natural highly mineralized bromine-iodine brine. Problems of Balneology, Physiotherapy and Exercise Therapy. 2014;91(2):38‑42. (In Russ.)

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Alterations in the activity of glutathione-dependent enzymes in erythrocytes of patients with acute pancreatitis of varying severity. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):10-15

Psoriasis: analysis of comorbid pathology. Russian Journal of Clinical Dermatology and Venereology. 2025;(1):16-21

Search of diagnostic and prognostic biomarkers of immunoinflammatory dermatoses by means of flow cytometry. Russian Journal of Clinical Dermatology and Venereology. 2025;(2):170-177

Nucleotide sequence variants in IL4 and TNFA genes in patients with dermatoses and xerosis. Russian Journal of Clinical Dermatology and Venereology. 2025;(2):178-184

Historical aspects and prospects of psoriasis treatment. Russian Journal of Clinical Dermatology and Venereology. 2025;(3):284-292

Key specific tools for assessment of life quality of patients with psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2025;(3):319-325

Psychodermatological aspects of psoriasis, current condition of problem. Russian Journal of Clinical Dermatology and Venereology. 2025;(4):403-411

New approach to clinical evaluation of nail lesions in psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2025;(4):453-460

Persistence of skin process remission in patients with moderate and severe psoriasis vulgaris in application of netakimab: a five-year observational study results. Russian Journal of Clinical Dermatology and Venereology. 2025;(4):462-468

Free radicals in reproductive processes. Russian Journal of Human Reproduction. 2025;(5):51-57

Abstract:

The authors report the results of the treatment of 64 patients presenting with psoriasis by the applications of a natural highly mineralized bromine-iodine brine. The method has been shown to be highly efficacious and safe. It allowed the clinical remission and marked improvement of the patients' clinical conditions to be achieved in 48 (77.4%) cases compared with 10 (27.8%) cases among the patients of the control group. Exacerbation was documented in a single patient with psoriatic erythrodermia. All the patients showed the normal results of general and biochemical clinical analyses of blood and urea throughout the study period. The applications of the natural highly mineralized bromine-iodine brine exerted the normalizing action on seven of the 8 characteristics of the lipid peroxidation process. It is maintained that the high effectiveness of the method in question can be accounted not only by the reflectory and humoral mechanisms of action of highly mineralized bromine-iodine brine but also by the marked exhaustion of the functional reserves of the mast cells under effect of the applications. It is concluded that an advantage of the proposed approach over standard balneotherapeutic procedures consists of the possibility to employ it not only at the base of a spa and health resort facility but also in a different setting with the involvement of the patients suffering from progressive psoriasis.

Keywords:

psoriasis

natural highly mineralized bromine-iodine brine

applications

lipid peroxidation

Authors:

El'kin V.D.

E.A. Vagner Perm State Medical Academy

Koriukina I.P.

GBOU VPO "Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.V. Vagnera" Minzdrava Rossii

Datskovskiĭ Ia.S.

GBOU VPO "Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera" Minzdrava Rossii

Plotnikova E.V.

E.A. Vagner Perm State Medical Academy

Close metadata

References:

Nadi L. Epidemiology of psoriasis. Curr. Drug Targets Inflamm. Allergy. 2004; 3 (2): 121-8.
Gelfand J.M., Weinstein R., Porter S.B., Neumann A.L., Berlin J.A., Margolis D.J. Prevalence and treatment of psoriasis in the United Kingdom: a population - based study. Arch. Dermatol. 2005; 141 (12): 1537-41.
Znamenskaya L.F., Melekhina L.E., Bogdanova E.V., Mineeva A.A. Zabolevaemost' i rasprostranennost' psoriaza v Rossiyskoy Federatsii [Psoriasis morbidity and prevalence in the Russian Federation]. Vestnik dermatologii i venerologii. 2012; 5: 20-9. [In russ.].
Barker B.S., Fry L. The immunology of psoriasis. Br. J. Dermatol. 1992; 126 (1): 1-9.
Kungurov N.V., Filimonkova N.N, Tuzankina I.A. Psoriaticheskaya bolezn' [Psoriatic disease]. Ekaterinburg: Izd-vo Yral. Un-ta; 2002. 193 p. [In russ.].
Aleksandrov V.A. Meditsinskaya klassifikatsiya lechebnykh natural'nylh vod, peloidov (lechebnykh gryazey) i klimatov SSSR. V kn.: Aleksandrov V.A., red. Osnovy kurortologii, t. 1. [The medical classification of therapeutic natural waters, peloids (therapeutic muds), and climates of the USSR. In. Aleksandrov V.A., ed. Fundamentals of balneotherapeutics, v. 1.]. M.: Medgiz; 1956: 9 -- 16. [In russ.].
Golshmid K.L. Opyt primeneniya iodobromnykh vod pri lechenii kozhnykh zabolevaniy [The experience with the application of iodine-bromine waters for the treatment of skin diseases]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kultury. 1957; 6: 60-2. [In russ.].
Karagezyan M.A., Sivak V.P. Prontsipy i metody bal'neoterapii bol'nykh s khronicheskimi dermatozami iodbromnymi vannami [The principles and methods of balneotghetherapy for the patients presentinng with chronic dermatoses with the use of iodine-bromine baths]. Sovetskaya meditsina. 1974; 11: 146-7. [In russ.].
Skripkin Yu.K., red. Kozhnye i venericheskie bolezni: Rukovodstvo dlya vrachey. T. 2 [Sktripkin Yu.K., ed. Cutaneous and venereal siseases: The guidelines for physicians. V. 1]. M.: Meditsina; 1995. 544 p. [In russ.].
Monakhov S.A., Perminova M.A., Shabliy R.A., Korchazhkina N.B., Olisova O.Yu. Metody fototerapii v lechenii i profilaktike khronicheskikh dermatozov [The application of phototherapeutic methods for the treatment and prevention of chronic dermatoses]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kultury. 2012; 4: 33-6. [In russ.].
Khairutdinov V.R., Pilyugin N.V., Ponomarenko G.N., Samedov A.V., Imyanitov E.N. Geneticheskie determinanty effektivnosti srednevolnovogo ul'trafioletovogo oblucheniya bol'nykh psoriazom [The genetic determinants of the effectiveness of medium wavelength irradiation of the patients suffering from psoriasis]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kultury. 2010; 6: 3-5. [In russ.].
Vetchinkin V.D., Korshunova V.M. Lechenie ekzemy i psoriaza rapnami applikatsiyami na ozere Bol'shoye Yarovoye Altaiskogo kraya [[The treatment of eczema and psoriasis by means of rapa applications on the lake Bol'shoye Yarovoye, Altaisky kray]. Vestnik dermatologii i venerologii. 1977; 7: 68-71. [In russ.].
Milyavsky A.I., Losev V.B. Lechenie rapnymi vannami bol'nykh khronicheskimi dermatoxami v Evpatorii [The treatment of the patients presenting with chronic dermatoses with the use of the rapa baths in Yevapatoriya]. Vestnik dermatologii i venerologii. 1978; 5: 71 -- 3. [In russ.].
Rybolovlev E.V. Effektivnost' lecheniya bol'nykh distroficheskim poliartriton khloridnymi natrievymi bromiodnyami vannami vysokoy mineralizatsii na kurorte Ust'-Kachka: Avtoref. diss…. cand. med. nauk [The effectiveness of the treatment of the patients presenting with distrophic poliarthritis with the use of higly mineralized sodium chloride iodine-bromine baths at the Ust'-Kachka health resort]. Synopsis of thesis for Cand.Med.Sci. degree]. Perm'; 1969. 14 p. [In russ.].
Vladimirov V.V., Mren'shikova L.V. Klimatograficheskie osobennosti Mertvogo morya [The pecific climatographic features of the Dead Sea]. Vestnik dermatologii i venerologii. 1996; 6: 54-6. [In russ.].
Bisharat Z., Alawi H. Treatment of psoriasis of the Dead Sea in Jordan. J. Eur. Acad. Dermatol. Venereol. 1995; 5(Suppl.1): S104. (Abstracts of 4th congress of European academy of dermatology and venereology. Brussels, Belgium, 1995.)
Stal'naya N.D., Gorishvili T.G. Metod opredeleniya malonovogo dial'degida s pomoshch'yu tiobarbiturovoy kisloty. V kn.: Orekhovich V.N., red. Sovremennye metody v biokhimii [The method for the detection of malonic dialdehyde with the use of thiobarbituric acid. In: Orekhovich V.N., ed. The modern methods in biochemistry]. M.: Meditsina; 1977: 66-8. [In russ.].
Mirzoev A.I., Klebanov G.I., Sherstneva M.P., Andryushchenko A.P. Perekisnoe okislenie lipidov syvorotki krovi krolikov s razlichnymi tireoidnaymi sostoyaniyami [Lipid peroxidation on the blood serum of the rabbits of different thyroid status]. Voprosy meditsinskoy khimii. 1985; 31 (2): 14-7. [In russ.].
Ulashchik V.S. Uchastie kozhi v realizatsii deistviya lechebnykh fizicheskikh faktorov [Participation of the skin in the realization of the action of therapeutic physical factors]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kultury. 1990; 2: 8-16. [In russ.].
Sidorov V.V. Vliyanie vysokomineralizovannogo bromiodnogo rastvora na techenie zatyazhnykh i khronicheskikh bolezney detey i vzroslykh: Avtoref. diss….d-ra med. nauk [The influence of the highly mineralized iodine-bromine solution on the course of long-standing and chronic diseases in the children and adults: Synopsis of thesis for D.Med.Sci. degree]. Perm'; 1999.48 p. [In russ.].
Sidorov V.V., Koryukina I.P., Tuev A.V. Teoreticheskie i prakticheskie aspekty primeneniya bromiodnogo rastvora vysokoy mineralizatsii u vzroslykh i detey na kurorte Ust'-Kachka. V kn.: Problemy kurortologii i fizioterapii na rubezhe vekov: Materialy mezhregional'noy nauchno-prakticheskoy konferentsii, posvyashchyonnoy 65-letiyu kurorta Ust'-Kachka [The theoretical and practical aspects of the application of the higly mineralized iodine-bromine solution for the teatment of the adults and children at the Ust'-Kachka health resort. In: The problems of balneotherapy and physiothedrapy at the break of the centuries: The materials of the inter-regional scientific and practical conference dedicated to the 65th anniversary of the Ust'-Kachka health resort]. M., Perm', Ust'-Kachka; 2000: 14 -- 5. [In russ.].