The treatment of perforation of the nasal septum (PNS) is one of the challenging problems currently facing otorhinolaryngology. The enhancement of the effectiveness of the conservative treatment of PNS was achieved through the three-stage development of the methodology including septal fixation in combination with targeted long-term drug application to the affected tissues. At the first stage of the study, characteristic features of the septal defects in patients with PNS were studied. At the second stage, we have developed the method for the conservative treatment of PNS based on the stenting of the nasal septum with the use of original heptangular splinters. At the third stage, the comprehensive comparative analysis was undertaken to estimate the effectiveness of the application of the original method of conservative treatment of the patients with PNS and traditional symptomatic therapy. It is concluded that the proposed original method for the treatment of patients with PNS based on the preventive stenting of the nasal septum original heptangular splinters one of which is equipped with a magnetic manipulation channel is an efficacious method for the conservative treatment of septal perforations. The method provides the basis for the new algorithm of management for the management of the patients suffering from PNS.