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Yartsev V.D.

Krasnov Research Institute of Eye Diseases

Atkova E.L.

Krasnov Research Institute of Eye Diseases

The role of local antiseptics in the prevention of coronavirus infection during endonasal interventions on the lacrimal ducts

Authors:

Yartsev V.D., Atkova E.L.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2022;87(1): 75‑80

Read: 1427 times


To cite this article:

Yartsev VD, Atkova EL. The role of local antiseptics in the prevention of coronavirus infection during endonasal interventions on the lacrimal ducts. Russian Bulletin of Otorhinolaryngology. 2022;87(1):75‑80. (In Russ.)
https://doi.org/10.17116/otorino20228701175

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References:

  1. Fennessy BG, Harney M, O’Sullivan MJ, Timon C. Antimicrobial prophylaxis in otorhinolaryngology/head and neck surgery. Clinical Otolaryngology. 2007;32(3):204-207.  https://doi.org/10.1111/j.1365-2273.2007.01440.x.
  2. Karaman E, Alimoglu Y, Aygun G, Kilic E, Yagiz C. Effect of septoplasty and per-operative antibiotic prophylaxis on nasal flora. B-ENT. 2012;8(1):13-19. 
  3. Kryukov AI, Eliseev OV. Pre- and intraoperative preparation of patients with pyoinflammatory diseases of the ear, pharynx and paranasal sinuses. Vestnik otorinolaringologii. 2004;1:39-41. (In Russ.).
  4. Georgievsky IV, Lopatin AS. Local antibacterial preoperative prophylaxis in rhinosurgery. Rossijskaya rinologiya. 2006;4:17-21. (In Russ.).
  5. Rusetsky YuYu, Sedykh TK, Chernyshenko IO, Martyanova NM. Effective antiseptic washing of surgical site during endoscopic adenotomy Rossijskaya rinologiya. 2013;21(1):11-15. (In Russ.).
  6. Al-Jabir A, Kerwan A, Nicola M, Alsafi Z, Khan M, Sohrabi C, O’Neill N, Iosifidis C, Griffin M, Mathew G, Agha R. Impact of the Coronavirus (COVID-19) pandemic on surgical practice — Part 2 (surgical prioritisation). International Journal of Surgery. 2020;79:233-248.  https://doi.org/10.1016/j.ijsu.2020.05.002
  7. Di Saverio S, Pata F, Gallo G, Carrano F, Scorza A, Sileri P, Smart N, Spinelli A, Pellino G. Coronavirus pandemic and colorectal surgery: practical advice based on the Italian experience. Colorectal Disease. 2020;22(6):625-634.  https://doi.org/10.1111/codi.15056
  8. Patel ZM, Fernandez-Miranda J, Hwang PH, Nayak JV, Dodd R, Sajjadi H, Jackler RK. Letter: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic. Neurosurgery. 2020;87(1):66-67.  https://doi.org/10.1093/neuros/nyaa125
  9. Tan L, Kovoor JG, Williamson P, Tivey DR, Babidge WJ, Collinson TG, Hewett PJ, Hugh TJ, Padbury RTA, Langley SJ, Maddern GJ. Personal protective equipment and evidence-based advice for surgical departments during COVID-19. ANZ Journal of Surgery. 2020;90(9):1566-1572. https://doi.org/10.1111/ans.16194
  10. Kleiboeker S, Cowden S, Grantham J, Nutt J, Tyler A, Berg A, Altrich M. SARS-CoV-2 viral load assessment in respiratory samples. Journal of Clinical Virology. 2020;129:104439. https://doi.org/10.1016/j.jcv.2020.104439
  11. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, Yu J, Kang M, Song Y, Xia J, Guo Q, Song T, He J, Yen HL, Peiris M, Wu J. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. The New England Journal of Medicine. 2020; 382(12):1177-1179. https://doi.org/10.1056/NEJMc2001737
  12. Mick P, Murphy R. Aerosol-generating otolaryngology procedures and the need for enhanced PPE during the COVID-19 pandemic: a literature review. Journal of Otolaryngology — Head and Neck Surgery. 2020;49(1):29.  https://doi.org/10.1186/s40463-020-00424-7
  13. Thamboo A, Lea J, Sommer DD, Sowerby L, Abdalkhani A, Diamond C, Ham J, Heffernan A, Cai Long M, Phulka J, Wu YQ, Yeung P, Lammers M. Clinical evidence based review and recommendations of aerosol generating medical procedures in otolaryngology — head and neck surgery during the COVID-19 pandemic. Journal of Otolaryngology — Head and Neck Surgery. 2020;49(1):28.  https://doi.org/10.1186/s40463-020-00425-6
  14. Gralton J, Tovey E, McLaws ML, Rawlinson WD. The role of particle size in aerosolised pathogen transmission: A review. The Journal of Infection. 2011;62(1):1-13.  https://doi.org/10.1016/j.jinf.2010.11.010
  15. an Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, Lloyd-Smith JO, de Wit E, Munster VJ. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. The New England Journal of Medicine. 2020;382(16):1564-1567. https://doi.org/10.1056/NEJMc2004973
  16. Ali MJ. A Surgical Protocol to Mitigate the SARS-CoV-2 Transmission Using Multifocal Povidone-Iodine Applications in Lacrimal Surgeries During Coronavirus Disease 2019 (COVID-19) Pandemic. Ophthalmic Plastic and Reconstructive Surgery. 2020;36(4): 416-417.  https://doi.org/10.1097/IOP.0000000000001746
  17. Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, Marimuthu K. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient. JAMA. 2020;323(16):1610-1612. https://doi.org/10.1001/jama.2020.3227
  18. Parhar HS, Tasche K, Brody RM, Weinstein GS, O’Malley BW, Shanti RM, Newman JG. Topical preparations to reduce SARS-CoV-2 aerosolization in head and neck mucosal surgery. Head and Neck. 2020;42(6):1268-1272. https://doi.org/10.1002/hed.26200
  19. Nikonov EL, Kryukov AI, Kunelskaya NL, Tsarapkin GYu, Vasilenko IP, Bondareva GP, Nosulya EV, Sudarev PA, Bessarab TP, Tovmasyan AS, Yanyushkina ES, Timofeeva MG, Kishinevsky AE, Chalov DM, Gorovaya EV. ENT care in the context of the new coronavirus infection COVID-19. Vestnik otorinolaringologii. 2020;85(4):70-76. (In Russ.). https://doi.org/10.17116/otorino20208504170
  20. Couloigner V, Schmerber S, Nicollas R, Coste A, Barry B, Makeieff M, Boudard P, Bequignon E, Morel N, Lescanne E; French Society of Otorhinolaryngology, Head, Neck Surgery (SFORL); French College of Otorhinolaryngology, Head, Neck Surgery; French Syndicate of ENT Specialists (SNORL). COVID-19 and ENT Surgery. European Annals of Otorhinolaryngology, Head and Neck Diseases. 2020;137(3):161-166.  https://doi.org/10.1016/j.anorl.2020.04.012
  21. Chari DA, Workman AD, Chen JX, Jung DH, Abdul-Aziz D, Kozin ED, Remenschneider AK, Lee DJ, Welling DB, Bleier BS, Quesnel AM. Aerosol Dispersion During Mastoidectomy and Custom Mitigation Strategies for Otologic Surgery in the COVID-19 Era. Otolaryngology — Head and Neck Surgery. 2020;194599820941835. https://doi.org/10.1177/0194599820941835
  22. Sorbello M, Rosenblatt W, Hofmeyr R, Greif R, Urdaneta F. Aerosol boxes and barrier enclosures for airway management in COVID-19 patients: A scoping review and narrative synthesis. British Journal of Anaesthesia. 2020;125(6):880-894.  https://doi.org/10.1016/j.bja.2020.08.038
  23. Ananth L, Hosamani P. Management of ENT Surgical Emergencies Amidst COVID-19 Lockdown: Our Experience in a Tertiary Referral Hospital. Indian Journal of Otolaryngology and Head and Neck Surgery. 2020;73(2):1-8.  https://doi.org/10.1007/s12070-020-01987-7
  24. Krajewska Wojciechowska J, Krajewski W, Zub K, Zatonski T. Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic. Auris Nasus Larynx. 2020;47(4):544-558.  https://doi.org/10.1016/j.anl.2020.05.022
  25. Ti LK, Ang LS, Foong TW, Ng BSW. What we do when a COVID-19 patient needs an operation: operating room preparation and guidance. Canadian Journal of Anaesthesia. 2020;67(6):756-758.  https://doi.org/10.1007/s12630-020-01617-4
  26. Dexter F, Parra MC, Brown JR, Loftus RW. Perioperative COVID-19 Defense: An Evidence-Based Approach for Optimization of Infection Control and Operating Room Management. Anesthesia and Analgesia. 2020;131(1):37-42.  https://doi.org/10.1213/ANE.0000000000004829
  27. Frank S, Capriotti J, Brown SM, Tessema B. Povidone-Iodine Use in Sinonasal and Oral Cavities: A Review of Safety in the COVID-19 Era. Ear, Nose, and Throat Journal. 2020;145561320932318. https://doi.org/10.1177/0145561320932318
  28. Khan MM, Parab SR. 0.5% povidone iodine irrigation in otorhinolaryngology surgical practice during COVID 19 pandemic. American Journal of Otolaryngology. 2020;41(6):102687. https://doi.org/10.1016/j.amjoto.2020.102687
  29. Khan MM, Parab SR, Paranjape M. Repurposing 0.5% povidone iodine solution in otorhinolaryngology practice in Covid 19 pandemic. American Journal of Otolaryngology. 2020;41(5):102618. https://doi.org/10.1016/j.amjoto.2020.102618
  30. Mady LJ, Kubik MW, Baddour K, Snyderman CH, Rowan NR. Consideration of povidone-iodine as a public health intervention for COVID-19: Utilization as “Personal Protective Equipment” for frontline providers exposed in high-risk head and neck and skull base oncology care. Oral Oncology. 2020;105:104724. https://doi.org/10.1016/j.oraloncology.2020.104724
  31. Loon SC, Teoh SC, Oon LL, Se-Thoe SY, Ling AE, Leo YS, Leong HN. The severe acute respiratory syndrome coronavirus in tears. The British Journal of Ophthalmology. 2004;88(7):861-863.  https://doi.org/10.1136/bjo.2003.035931
  32. Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, Wu K. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmology. 2020;138(5):575-578.  https://doi.org/10.1001/jamaophthalmol.2020.1291
  33. Zhang X, Chen X, Chen L, Deng C, Zou X, Liu W, Yu H, Chen B, Sun X. The evidence of SARS-CoV-2 infection on ocular surface. The Ocular Surface. 2020;18(3):360-362.  https://doi.org/10.1016/j.jtos.2020.03.010
  34. Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. The Journal of Hospital Infection. 2020;104(3):246-251.  https://doi.org/10.1016/j.jhin.2020.01.022
  35. Kampf G, Todt D, Pfaender S, Steinmann E. Corrigendum to “Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents” [J Hosp Infect 104 (2020) 246-251]. The Journal of Hospital Infection. 2020;105(3):587.  https://doi.org/10.1016/j.jhin.2020.06.001
  36. Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of In Vitro Inactivation of SARS CoV-2 with Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses. Journal of Prosthodontics. 2020;29(7):599-603.  https://doi.org/10.1111/jopr.13220.
  37. Sapkota M, Wyatt TA. Alcohol, Aldehydes, Adducts and Airways. Biomolecules. 2015;5(4):2987-3008. https://doi.org/10.3390/biom5042987
  38. Vetter A, Augustijns P, Bernkop-Schnurch A. Solubilizing agents in nasal formulations and their effect on ciliary beat frequency. Toxicology In Vitro. 2012;26(1):150-156.  https://doi.org/10.1016/j.tiv.2011.10.011
  39. Workman AD, Cohen NA. The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium. American Journal of Rhinology and Allergy. 2014;28(6):454-464.  https://doi.org/10.2500/ajra.2014.28.4092
  40. Reimer K, Wichelhaus TA, Schafer V, Rudolph P, Kramer A, Wutzler P, Ganzer D, Fleischer W. Antimicrobial effectiveness of povidone-iodine and consequences for new application areas. Dermatology. 2002;204(Suppl 1):114-120.  https://doi.org/10.1159/000057738
  41. Kim JH, Rimmer J, Mrad N, Ahmadzada S, Harvey RJ. Betadine has a ciliotoxic effect on ciliated human respiratory cells. The Journal of Laryngology and Otology. 2015;129(Suppl 1):45-50.  https://doi.org/10.1017/S0022215114002746
  42. Ramezanpour M, Smith JLP, Psaltis AJ, Wormald PJ, Vreugde S. In vitro safety evaluation of a povidone-iodine solution applied to human nasal epithelial cells. International Forum of Allergy and Rhinology. 2020;10(10):1141-1148. https://doi.org/10.1002/alr.22575
  43. Sato S, Miyake M, Hazama A, Omori K. Povidone-iodine-induced cell death in cultured human epithelial HeLa cells and rat oral mucosal tissue. Drug and Chemical Toxicology. 2014;37(3):268-275.  https://doi.org/10.3109/01480545.2013.846364
  44. Berkelman RL, Holland BW, Anderson RL. Increased bactericidal activity of dilute preparations of povidone-iodine solutions. Journal of Clinical Microbiology. 1982;15(4):635-639.  https://doi.org/10.1128/JCM.15.4.635-639.1982
  45. Pelletier JS, Tessema B, Frank S, Westover JB, Brown SM, Capriotti JA. Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). Ear, Nose, and Throat Journal. 2021; 100(2 Suppl):192S-196S. https://doi.org/10.1177/0145561320957237
  46. Anderson DE, Sivalingam V, Kang AEZ, Ananthanarayanan A, Arumugam H, Jenkins TM, Hadjiat Y, Eggers M. Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease. Infectious Diseases and Therapy. 2020;9(3):669-675.  https://doi.org/10.1007/s40121-020-00316-3
  47. Eggers M, Eickmann M, Zorn J. Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA). Infectious Diseases and Therapy. 2015;4(4):491-501.  https://doi.org/10.1007/s40121-015-0091-9
  48. Chorney SR, Rizzi MD, Dedhia K. Considerations for povidone-iodine antisepsis in pediatric nasal and pharyngeal surgery during the COVID-19 pandemic. American Journal of Otolaryngology. 2020;41(6):102737. https://doi.org/10.1016/j.amjoto.2020.102737
  49. Carrim ZI, Mackie G, Gallacher G, Wykes WN. The efficacy of 5% povidone-iodine for 3 minutes prior to cataract surgery. European Journal of Ophthalmology. 2009;19(4):560-564.  https://doi.org/10.1177/112067210901900407
  50. Mino de Kaspar H, Chang RT, Singh K, Egbert PR, Blumenkranz MS, Ta CN. Prospective randomized comparison of 2 different methods of 5% povidone-iodine applications for anterior segment intraocular surgery. Archives of Ophthalmology. 2005;123(2):161-165.  https://doi.org/10.1001/archopht.123.2.161
  51. Koerner JC, George MJ, Meyer DR, Rosco MG, Habib MM. Povidone-iodine concentration and dosing in cataract surgery. Survey of Ophthalmology. 2018;63(6):862-868.  https://doi.org/10.1016/j.survophthal.2018.05.002
  52. Speaker MG, Menikoff JA. Prophylaxis of endophthalmitis with topical povidone-iodine. Ophthalmology. 1991;98(12):1769-1775. https://doi.org/10.1016/s0161-6420(91)32052-9
  53. Vazirani J, Basu S. Role of topical, subconjunctival, intracameral, and irrigative antibiotics in cataract surgery. Current Opinion in Ophthalmology. 2013;24(1):60-65.  https://doi.org/10.1097/ICU.0b013e32835a93be
  54. Li B, Nentwich MM, Hoffmann LE, Haritoglou C, Kook D, Kampik A, Sheng M, Mino de Kaspar H. Comparison of the efficacy of povidone-iodine 1.0%, 5.0%, and 10.0% irrigation combined with topical levofloxacin 0,3% as preoperative prophylaxis in cataract surgery. Journal of Cataract and Refractive Surgery. 2013;39(7):994-1001. https://doi.org/10.1016/j.jcrs.2013.02.039
  55. Nentwich MM, Rajab M, Ta CN, He L, Grueterich M, Haritoglou C, Gandorfer A, Kampik A, Mino De Kaspar H. Application of 10% povidone iodine reduces conjunctival bacterial contamination rate in patients undergoing cataract surgery. European Journal of Ophthalmology. 2012;22(4):541-546.  https://doi.org/10.5301/ejo.5000093
  56. Accepte11.01.2021 

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